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Categories: Biology: Genetics, Mathematics: Modeling
Published Here's how a worm's embryonic cells changed its development potential
(via sciencedaily.com) Original source Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.
Published Woolly mammoths evolved smaller ears and woolier coats over the 700,000 years that they roamed the Siberian steppes
(via sciencedaily.com) Original source A team of researchers compared the genomes of woolly mammoths with modern day elephants to find out what made woolly mammoths unique, both as individuals and as a species. The investigators report that many of the woolly mammoth's trademark features -- including their woolly coats and large fat deposits -- were already genetically encoded in the earliest woolly mammoths, but these and other traits became more defined over the species' 700,000+ year existence. They also identified a gene with several mutations that may have been responsible for the woolly mammoth's miniscule ears.
Published Researchers clear the way for well-rounded view of cellular defects
(via sciencedaily.com) Original source New research investigates how cells divide, particularly in the fibrous environment of living tissue. Cells are typically studied in a flat environment, and the difference between flat and fibrous landscapes opens new windows into the behavior of cells and the diseases that impact them.
Published New atomic-scale understanding of catalysis could unlock massive energy savings
(via sciencedaily.com) Original source In an advance they consider a breakthrough in computational chemistry research, chemical engineers have developed a model of how catalytic reactions work at the atomic scale. This understanding could allow engineers and chemists to develop more efficient catalysts and tune industrial processes -- potentially with enormous energy savings, given that 90% of the products we encounter in our lives are produced, at least partially, via catalysis.
Published Broccoli consumption protects gut lining, reduces disease, in mice
(via sciencedaily.com) Original source Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidence of cancer and type 2 diabetes. In a recent study, researchers found that broccoli contains certain molecules that bind to a receptor within mice and help to protect the lining of the small intestine, thereby inhibiting the development of disease. The findings lend support to the idea that broccoli truly is a 'superfood.'
Published Blind dating in bacteria evolution
(via sciencedaily.com) Original source A team of researchers reconstructed long-extinct proteins of a UV protection system of cyanobacteria. The surprising result: the proteins were already compatible with each other when they first met. This discovery expands the knowledge horizon on the rules of evolution.
Published Researchers create embryo-like structures from monkey embryonic stem cells
(via sciencedaily.com) Original source Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study. Investigators now report on the creation of embryo-like structures from monkey embryonic stem cells. The investigators also transferred these embryo-like structures into the uteruses of female monkeys and determined that the structures were able to implant and elicit a hormonal response similar to pregnancy.
Published Random matrix theory approaches the mystery of the neutrino mass
(via sciencedaily.com) Original source Scientists analyzed each element of the neutrino mass matrix belonging to leptons and showed theoretically that the intergenerational mixing of lepton flavors is large. Furthermore, by using the mathematics of random matrix theory, the research team was able to demonstrate, as much as is possible at this stage, why the calculation of the squared difference of the neutrino masses are in close agreement with the experimental results in the case of the seesaw model with the random Dirac and Majorana matrices. The results of this research are expected to contribute to the further development of particle theory research, which largely remains a mystery.
Published Humans vs. Bacteria: Differences in ribosome decoding revealed
(via sciencedaily.com) Original source Scientists have found that human ribosomes decode mRNA slower than bacteria, with implications for drug development.
Published Complex assembly process involved in DNA virus replication
(via sciencedaily.com) Original source In a twist on the question, 'Which came first, the chicken or the egg?', scientists have long faced a similar question about how human adenovirus replicates: 'Which comes first, assembly of the viral particle, or packaging of the viral genome?' Now, in a new study, scientists have answered that question, showing that viral proteins use a process called phase separation to coordinate production of viral progeny.
Published A cold-specialized icefish species underwent major genetic changes as it migrated to temperate waters
(via sciencedaily.com) Original source Biologists have explored the genetic mechanisms underlying the transition from freezing Antarctic waters to more temperature waters by Antarctic Notothenioid fish.
Published How were amino acids, one of the key building blocks of life, formed before the origin of life on Earth?
(via sciencedaily.com) Original source The amino acid abundances of two Ryugu particles were measured and compared with their rocky components. The results demonstrate the important role that water plays in the formation of amino acids on the giant precursors of asteroids like Ryugu. Our solar system formed from a molecular cloud, which was composed of gas and dust that was emitted into the interstellar medium (ISM), a vast space between stars. On collapse of the molecular cloud, the early sun was formed, with a large disk of gas and dust orbiting it. The dusty material collided to produce rocky material that would eventually grow in size to give large bodies called planetesimals.
Published A miniature heart in a petri dish: Organoid emulates development of the human heart
(via sciencedaily.com) Original source A team has induced stem cells to emulate the development of the human heart. The result is a sort of 'mini-heart' known as an organoid. It will permit the study of the earliest development phase of our heart and facilitate research on diseases.
Published Study to decode microbe-gut signaling suggests potential new treatment for IBD
(via sciencedaily.com) Original source Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
Published Squash bees flourish in response to agricultural intensification
(via sciencedaily.com) Original source While pollinator populations of many species have plummeted worldwide, one bee species is blowing up the map with its rapid population expansion. The key to this insect's success? Its passion for pumpkins, zucchinis, and other squashes, and the massive increase in cultivation of these crops across North America over the last 1,000 years. A new study found that the squash bee (Eucera pruinosa) has evolved in response to intensifying agriculture -- namely squashes in the genus Curcurbita. The research has demonstrated the role of agriculture as an evolutionary force acting on a wild insect pollinator and may have implications for food security.
Published DELLA proteins could hold key to the next Green Revolution
(via sciencedaily.com) Original source A family of 'promiscuous' proteins found in all land plants is responsible for many different plant functions, despite remaining relatively unchanged for over 450 million years.
Published Cells refine palm fat into olive oil
(via sciencedaily.com) Original source For more than 50 years, it has been suspected that fat cells constantly remodel the lipids they store. Researchers have now demonstrated this process directly for the first time using culture cells. Among other things, the study shows that the cells quickly eliminate harmful fatty acids. They refine others into molecules that can be used more effectively. In the long term, this turns the components of palm fat into the building blocks of high-quality olive oil, for example.
Published Cold is beneficial for healthy aging, at least in animals
(via sciencedaily.com) Original source A lower body temperature is one of the most effective mechanisms to prolong the lifespan of animals. New research has now described precisely how this works. The scientists show that cold can prevent the pathological aggregation of proteins typical for two aging-associated neurodegenerative diseases.
Published Wastewater more potent breeding ground for antibiotic resistance than previously known
(via sciencedaily.com) Wastewater is a more potent environment for antibiotic resistance to evolve than previously known. A study shows that wastewaters have unique characteristics, allowing resistance genes to start their journey from harmless bacteria to those that cause disease.
Published Form is (mal)function: Protein's shape lets bacteria disarm it
(via sciencedaily.com) Shigella bacteria can infect humans but not mice. A team can now explain why. Their findings may explain the multifariousness of a key weapon of our immune system.