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Categories: Biology: Genetics, Mathematics: Modeling

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An international team of bee researchers has integrated a calcium sensor into honey bees to enable the study of neural information processing including response to odors. This also provides insights into how social behavior is located in the brain.

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In early cytological studies chromatids of metaphase chromosomes were suggested to coil into a spiral called chromonema. This assumption was recently supported by chromosomce conformation capture sequencing. Still, the direct visualization of the coiled chromonema confirming the helical model was lacking. Now, an international research team provides the direct proof of the helical coiling of condensed chromatids via super-resolution microscopy of specifically labelled chromonema regions.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.

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A detailed atlas of gene expression in the zebrafish brain.

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Researchers test cognitive abilities of the language model GPT-3.

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A new machine learning model can predict traffic activity in different zones of cities. To do so, a researcher used data from a main car-sharing company in Italy as a proxy for overall city traffic. Understanding how different urban zones interact can help avoid traffic jams, for example, and enable targeted responses of policy makers -- such as local expansion of public transportation.

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Biochemists have succeeded in resurrecting the ancestral genes of five detoxifying enzymes which are present in all tetrapods to show how their divergence in function has occurred.

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By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today -- including plants, animals, and humans.

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Textbooks will tell you that in dividing cells, production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level. Molecular biologists have now discovered that this is not true: protein synthesis shows two peaks and lipid synthesis peaks once.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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Octopus arms coordinate nearly infinite degrees of freedom to perform complex movements such as reaching, grasping, fetching, crawling, and swimming. How these animals achieve such a wide range of activities remains a source of mystery, amazement, and inspiration. Part of the challenge comes from the intricate organization and biomechanics of the internal muscles.

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Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to proliferate, the polymerase of the influenza A virus has to be modified many times through enzymes in the host cells. The team of researchers was able to produce a comprehensive map of types of modification. Medicines directed against the enzymes woud be resilient to rapid mutations in the virus, thus offering great potential for the future.

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A team has developed a method for selectively manipulating genetically engineered cells with ultrasound.

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Growing wheat in drought conditions may be easier in the future. Researchers found the right number of copies of a specific group of genes can stimulate longer root growth, enabling wheat plants to pull water from deeper supplies.

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Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new study.

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High-resolution microscopy techniques, for example electron microscopy or super-resolution microscopy, produce huge amounts of data. The visualization, analysis and dissemination of such large imaging data sets poses significant challenges. Now, these tasks can be carried out using MoBIE, which stands for Multimodal Big Image Data Exploration, a new user-friendly, freely available tool. This means that researchers such as biologists, who rely on high-resolution microscopy techniques, can incorporate multiple data sets to study the processes of life at the very smallest scales.

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Theoretical chemists have developed a theory that can predict the threshold at which quantum dynamics switches from 'orderly' to 'random,' as shown through research using large-scale computations on photosynthesis models.

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Using ensemble learning techniques and longitudinal data from a large naturalistic driving study, researchers have developed a novel, interpretable and highly accurate algorithm for predicting mild cognitive impairment and dementia in older drivers. Digital markers refer to variables generated from data captured through recording devices in the real-world setting. These data could be processed to measure driving behavior, performance and tempo-spatial pattern in exceptional detail.

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It was the height of summer 2022 when the calls started coming in. Scores of dead deer suddenly littered rural properties and park preserves, alarming the public and inconveniencing landowners. According to officials at the Urbana Park District, it was Epizootic Hemorrhagic Disease (EHD), a midge-borne viral illness that pops up in white-tailed deer populations around the state every few years. And when susceptible deer are infected, they die within days. Now, scientists have found gene variants in deer associated with the animals' susceptibility to EHD.

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Researchers have created and preliminarily tested what they believe may be one of the first models for predicting who has the highest probability of being resistant to COVID-19 in spite of exposure to SARS-CoV-2, the virus that causes it.