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Categories: Biology: Genetics, Mathematics: Modeling
Published New one-step method to make multiple edits to a cell's genome
(via sciencedaily.com) Original source A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells.
Published Innovative, highly accurate AI model can estimate lung function just by using chest x-rays
(via sciencedaily.com) Original source An artificial intelligence (AI) model that can estimate with high accuracy a person's lung function just by using a chest radiograph has been successfully developed.
Published New bio-based tool quickly detects concerning coronavirus variants
(via sciencedaily.com) Original source Researchers have developed a bioelectric device that can detect and classify new variants of coronavirus to identify those that are most harmful. It has the potential to do the same with other viruses, as well.
Published Genomic data integration improves prediction accuracy of apple fruit traits
(via sciencedaily.com) Original source Genotyping techniques can be used to select fruit trees with desired traits at the seedling stage, increasing the efficiency of fruit tree breeding. However, so far, there are multiple different genotyping systems, each generating distinct datasets. In a recent study, Japanese scientists revealed that integrating genomic data obtained with different genotyping systems can effectively combine with historical data, leveraging the accuracy of genomic predictions.
Published GeneMAP discovery platform will help define functions for 'orphan' metabolic proteins
(via sciencedaily.com) Original source Researchers have developed a discovery platform to probe the function of genes involved in metabolism -- the sum of all life-sustaining chemical reactions. The investigators used the new platform, called GeneMAP (Gene-Metabolite Association Prediction), to identify a gene necessary for mitochondrial choline transport.
Published Not so selfish after all: Viruses use freeloading genes as weapons
(via sciencedaily.com) Original source Certain pieces of DNA have been labeled as 'selfish genetic elements' due to notions that they don't contribute to a host organism's survival. Instead, researchers have now discovered that these elements have been weaponized and play a crucial role by cutting off a competitor's ability to reproduce.
Published Deep machine-learning speeds assessment of fruit fly heart aging and disease, a model for human disease
(via sciencedaily.com) Original source Drosophila -- known as fruit flies -- are a valuable model for human heart pathophysiology, including cardiac aging and cardiomyopathy. However, a choke point in evaluating fruit fly hearts is the need for human intervention to measure the heart at moments of its largest expansion or its greatest contraction to calculate cardiac dynamics. Researchers now show a way to significantly cut the time needed for that analysis while utilizing more of the heart region, using deep learning and high-speed video microscopy.
Published Never-before-seen view of gene transcription captured
(via sciencedaily.com) Original source New tech reveals findings that address long-standing theories about how bacteria begin the process of making RNA from DNA.
Published Do genes-in-pieces code for proteins that fold in pieces?
(via sciencedaily.com) Original source A new study offers new insights into the evolution of foldable proteins.
Published Researchers uncover key mechanisms in chromosome structure development
(via sciencedaily.com) Original source Researchers are making strides in understanding how chromosome structures change throughout the cell's life cycle.
Published Machine learning could aid efforts to answer long-standing astrophysical questions
(via sciencedaily.com) Original source Physicists have developed a computer program incorporating machine learning that could help identify blobs of plasma in outer space known as plasmoids. In a novel twist, the program has been trained using simulated data.
Published A new breakthrough in understanding regeneration in a marine worm
(via sciencedaily.com) Original source The sea worm Platynereis dumerilii is only a few centimeters long but has a remarkable ability: in just a few days, it can regenerate entire parts of its body after an injury or amputation. By focusing more specifically on the mechanisms at play in the regeneration of this worm's tail, a research team has observed that gut cells play a role in the regeneration of the intestine as well as other tissues such as muscle and epidermis.
Published Near chromosome-level genome of the Mojave poppy bee
(via sciencedaily.com) Original source Scientists have developed a near chromosome-level genome for the Mojave poppy bee, a specialist pollinator of conservation concern.
Published Moving beyond the 80-year-old solar cell equation
(via sciencedaily.com) Original source Physicists have made a significant breakthrough in solar cell technology by developing a new analytical model that improves the understanding and efficiency of thin-film photovoltaic (PV) devices.
Published Research shows how RNA 'junk' controls our genes
(via sciencedaily.com) Original source Researchers have made a significant advance in understanding how genes are controlled in living organisms. The new study focuses on critical snippets of RNA in the tiny, transparent roundworm Caenorhabditis elegans (C. elegans). The study provides a detailed map of the 3'UTR regions of RNA in C. elegans. 3'UTRs (untranslated regions) are segments of RNA involved in gene regulation.
Published Proteins and fats can drive insulin production for some, paving way for tailored nutrition
(via sciencedaily.com) Original source When it comes to managing blood sugar levels, most people think about counting carbs. But new research shows that, for some, it may be just as important to consider the proteins and fats in their diet. The study is the first large-scale comparison of how different people produce insulin in response to each of the three macronutrients: carbohydrates (glucose), proteins (amino acids) and fats (fatty acids). The findings reveal that production of the blood sugar-regulating hormone is much more dynamic and individualized than previously thought, while showing for the first time a subset of the population who are hyper-responsive to fatty foods.
Published Genetic patterns of world's farmed, domesticated foxes revealed via historical deep-dive
(via sciencedaily.com) Original source Domesticated animals play a prominent role in our society, with two-thirds of American families enjoying the companionship of pets and many others relying on animal products for their nutritional needs. But the process of domestication remains a bit of a mystery.
Published Degradation of cell wall key in the spread of antibiotic resistance
(via sciencedaily.com) Original source A study provides new clues in the understanding of how antibiotic resistance spreads. The study shows how an enzyme breaks down the bacteria's protective outer layer, the cell wall, and thus facilitates the transfer of genes for resistance to antibiotics.
Published Researchers thwart resistant bacteria's strategy
(via sciencedaily.com) Original source Bacteria are experts at evolving resistance to antibiotics. One resistance strategy is to cover their cell walls in sticky and gooey biofilm that antibiotics cannot penetrate. A new discovery could put a stop to this strategy.
Published AI model finds the cancer clues at lightning speed
(via sciencedaily.com) Original source AI model finds the cancer clues at lightning speed. Researchers have developed an AI model that increases the potential for detecting cancer through sugar analyses. The AI model is faster and better at finding abnormalities than the current semi-manual method.