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Categories: Biology: Genetics, Mathematics: Modeling
Published Modern plant enzyme partners with surprisingly ancient protein
(via sciencedaily.com) Original source Scientists have discovered that a protein responsible for the synthesis of a key plant material evolved much earlier than suspected. This new research explored the origin and evolution of the biochemical machinery that builds lignin, a structural component of plant cell walls with significant impacts on the clean energy industry.
Published Sweet taste receptor affects how glucose is handled metabolically by humans
(via sciencedaily.com) Original source The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption and assimilation, as part of this system. A team found that stimulation and inhibition of the sweet receptor helps regulate glucose metabolism in humans and may have implications for managing such metabolic disorders as diabetes.
Published Scientists discover mechanism of sugar signaling in plants
(via sciencedaily.com) Original source A paper describes how the moving parts of a particular plant protein control whether plants can grow and make energy-intensive products such as oil -- or instead put in place a series of steps to conserve precious resources. The study focuses specifically on how the molecular machinery is regulated by a molecule that rises and falls with the level of sugar -- plants' main energy source.
Published Zombie cells in the sea: Viruses keep the most common marine bacteria in check
(via sciencedaily.com) Original source Marine microbes control the flux of matter and energy essential for life in the oceans. Among them, the bacterial group SAR11 accounts for about a third of all the bacteria found in surface ocean waters. A study now reveals that at times nearly 20% of SAR11 cells are infected by viruses, significantly reducing total cell numbers. The viruses can also transform these once thriving bacteria into zombies, a phenomenon observed for the first time and widespread in the oceans.
Published Plants restrict use of 'Tipp-Ex proteins'
(via sciencedaily.com) Original source Plants have special corrective molecules at their disposal that can make retrospective modifications to copies of genes. However, it would appear that these 'Tipp-Ex proteins' do not have permission to work in all areas of the cell, only being used in chloroplasts and mitochondria. A study has now explained why this is the case. It suggests that the correction mechanism would otherwise modify copies that have nothing wrong with them, with fatal consequences for the cell.
Published Fruit fly wing research offers window into birth defects
(via sciencedaily.com) Original source If fruit fly wings do not develop into the right shape, the flies will die. Researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments for birth defects.
Published A new 'rule of biology' may have come to light, expanding insight into evolution and aging
(via sciencedaily.com) Original source A molecular biologist may have found a new 'rule of biology.' The rule challenges long-held notions that most living organisms prefer stability over instability because stability requires less energy and fewer resources.
Published Large language models can't effectively recognize users' motivation, but can support behavior change for those ready to act
(via sciencedaily.com) Original source Large language model-based chatbots can't effectively recognize users' motivation when they are hesitant about making healthy behavior changes, but they can support those who are committed to take action, say researchers.
Published Scientists use generative AI to answer complex questions in physics
(via sciencedaily.com) Original source Researchers used generative AI to develop a physics-informed technique to classify phase transitions in materials or physical systems that is much more efficient than existing machine-learning approaches.
Published New sensor gives unprecedented look at changes in cell's energy 'currency'
(via sciencedaily.com) Original source A new sensor is giving researchers the best look yet at ATP levels inside living cells, enabling scientists to study in greater detail than ever before how fluctuations in this cellular currency affect the cell and contribute to disease.
Published Researchers wrestle with accuracy of AI technology used to create new drug candidates
(via sciencedaily.com) Original source Researchers have determined that a protein prediction technology can yield accurate results in the hunt to efficiently find the best possible drug candidates for many conditions.
Published Bioengineered enzyme creates natural vanillin from plants in one step
(via sciencedaily.com) Original source Vanilla, the most widely used flavoring compound in confectionaries and cosmetics, gets its sweet flavor and aroma from the chemical compound -- 'vanillin'. However, the large-scale production of natural vanillin is impeded by the lack of microbial processes and enzymes which can commercially generate vanillin. Now, researchers have genetically engineered a novel enzyme which can convert ferulic acid from plant waste into vanillin in a one-step sustainable process.
Published Wavefunction matching for solving quantum many-body problems
(via sciencedaily.com) Original source Strongly interacting systems play an important role in quantum physics and quantum chemistry. Stochastic methods such as Monte Carlo simulations are a proven method for investigating such systems. However, these methods reach their limits when so-called sign oscillations occur. This problem has now been solved using the new method of wavefunction matching.
Published Heating proteins to body temperature reveals new drug targets
(via sciencedaily.com) Original source Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications. The findings could revolutionize wide swathes of biology by fundamentally changing how protein structure is studied and leveraged for drug design.
Published Now we know, what gets roots to grow: Can help in future droughts
(via sciencedaily.com) Original source A biological mechanism familiar to people who fast helps plant roots grow strong. The discovery provides an answer to a long-unanswered question and a deeper understanding of the 'mouths' of plants that can help to develop climate-resilient crops.
Published Exploring the mechanism behind drug eruptions in the skin
(via sciencedaily.com) Original source Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used genetically engineered mice to demonstrate the role of HLA in mediating intracellular reactions in keratinocytes, leading to drug eruptions in the skin. Their findings could lead to improved preventive and treatment measures for drug eruptions.
Published Drug compounds to combat neurodegenerative diseases
(via sciencedaily.com) Original source Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins. Prion disease is an umbrella term for a group of fatal and currently untreatable neurodegenerative diseases that not only affect humans, but also wild and captive animals. These diseases include Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE, or 'mad cow disease'), and chronic wasting disease (CWD) affecting deer, elk and moose.
Published Some mice may owe their monogamy to a newly evolved type of cell
(via sciencedaily.com) Original source What makes the oldfield mouse steadfastly monogamous throughout its life while its closest rodent relatives are promiscuous? The answer may be a previously unknown hormone-generating cell. Scientists discover the cells and hormones that inspire mice to nurture their young; the same hormones are also present in humans.
Published Genetics provide key to fight crown-of-thorns starfish
(via sciencedaily.com) Original source Scientists are one step closer to combating coral-destroying crown-of-thorns starfish, following a study into the pest's genetics.
Published Century of statistical ecology reviewed
(via sciencedaily.com) Original source A special review examines highly-cited papers in statistical ecology. The review, which covers a century of research, details how models and concepts have evolved alongside increasing computational power.