Showing 20 articles starting at article 421
< Previous 20 articles Next 20 articles >
Categories: Biology: Genetics, Mathematics: Modeling
Published Empty 'backpacks' activate the immune system against cancer
(via sciencedaily.com) Original source Researchers have discovered that the mere act of attaching their microparticle 'backpacks' to neutrophils is enough to activate them against cancer -- no drugs needed. In experiments, backpack-bearing neutrophils shrank tumors and extended the survival of mice with cancer, and treated animals retained an immune memory of the disease. This approach opens the door to a new class of drug-free immunotherapy for cancer.
Published A protein found in human sweat may protect against Lyme disease
(via sciencedaily.com) Original source Human sweat contains a protein that may protect against Lyme disease. About one-third of the population carries a genetic variant of this protein that is associated with Lyme disease in genome-wide association studies.
Published Genes identified that allow bacteria to thrive despite toxic heavy metal in soil
(via sciencedaily.com) Original source Some soil bacteria can acquire sets of genes that enable them to pump the heavy metal nickel out of their systems, a study has found. This enables the bacteria to not only thrive in otherwise toxic soils but help plants grow there as well. A research team pinpointed a set of genes in wild soil bacteria that allows them to do this in serpentine soils which have naturally high concentrations of toxic nickel. The genetic discovery could help inform future bioremediation efforts that seek to return plants to polluted soils.
Published New technique helps AI tell when humans are lying
(via sciencedaily.com) Original source Researchers have developed a new training tool to help artificial intelligence (AI) programs better account for the fact that humans don't always tell the truth when providing personal information. The new tool was developed for use in contexts when humans have an economic incentive to lie, such as applying for a mortgage or trying to lower their insurance premiums.
Published Engineers measure pH in cell condensates
(via sciencedaily.com) Original source In a first for the condensate field, researchers have figured out how nucleolar sub-structures are assembled. This organization gives rise to unique pH profiles within nucleoli, which they measured and compared with the pH of nearby non-nucleolar condensates including nuclear speckles and Cajal bodies.
Published Machine learning classifier accelerates the development of cellular immunotherapies
(via sciencedaily.com) Original source Making a personalized T cell therapy for cancer patients currently takes at least six months. Scientists have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.
Published Protein fragments ID two new 'extremophile' microbes--and may help find alien life
(via sciencedaily.com) Original source Perfectly adapted microorganisms live in extreme environments from deep-sea trenches to mountaintops. Learning more about how these extremophiles survive in hostile conditions could inform scientists about life on Earth and potential life on other planets.
Published Vac to the future
(via sciencedaily.com) Original source Scientists recently published the results of a competition that put researchers to the test. For the competition, part of the NIH-funded Computational Models of Immunity network, teams of researchers from different institutions offered up their best predictions regarding B. pertussis (whooping cough) vaccination.
Published It's hearty, it's meaty, it's mold
(via sciencedaily.com) Original source Scientists are exploring how tuning the genomes of mushrooms and molds can transform these food sources into gourmet, nutrient-packed meals made with minimal processing and a light environmental footprint.
Published New bioengineered protein design shows promise in fighting COVID-19
(via sciencedaily.com) Original source A recent scientific breakthrough has emerged from the work of researchers aiming to combat SARS-CoV-2, the virus responsible for COVID-19. The study focuses on the design and development of a novel protein capable of binding to the spike proteins found on the surface of the coronavirus. The goal behind this innovative approach is twofold: first, to identify and recognize the virus for diagnostic purposes, and second, to hinder its ability to infect human cells.
Published New discovery reveals how the egg controls sperm entry
(via sciencedaily.com) Original source After the egg has been fertilized by a sperm, the surrounding egg coat tightens, mechanically preventing the entry of additional sperm and the ensuing death of the embryo, a new study finds. The work also explains how mutations in egg coat proteins can cause female infertility and may eventually lead to new contraceptive methods.
Published Even cells know the importance of recycling
(via sciencedaily.com) Original source Researchers uncovered the mechanistic details behind how several proteins interact to help cells recognize and remove damaged mitochondria. Optineurin (OPTN) and its interactions are needed to provide a contact site for another protein, Tank-binding kinase 1 (TBK1), during this process. The OPTN-TBK1 relationship is necessary for these mitochondria to be recognized and eliminated from the cell. This mechanism may have relevance for developing drugs to treat Parkinson's disease.
Published Sulfur and the origin of life
(via sciencedaily.com) Original source A new study shines a spotlight on sulfur, a chemical element that, while all familiar, has proved surprisingly resistant to scientific efforts in probing its role in the origin of life.
Published AI for astrophysics: Algorithms help chart the origins of heavy elements
(via sciencedaily.com) Original source The origin of heavy elements in our universe is theorized to be the result of neutron star collisions, which produce conditions hot and dense enough for free neutrons to merge with atomic nuclei and form new elements in a split-second window of time. Testing this theory and answering other astrophysical questions requires predictions for a vast range of masses of atomic nuclei. Scientists are using machine learning algorithms to successfully model the atomic masses of the entire nuclide chart -- the combination of all possible protons and neutrons that defines elements and their isotopes.
Published Tryptophan in diet, gut bacteria protect against E. coli infection
(via sciencedaily.com) Original source Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure.
Published New computational strategy boosts the ability of drug designers to target proteins inside the membrane
(via sciencedaily.com) Original source Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new custom-designed proteins that can efficiently reach these 'intramembrane' targets.
Published Researchers develop a new control method that optimizes autonomous ship navigation
(via sciencedaily.com) Original source Existing ship control systems using Model Predictive Control for Maritime Autonomous Surface Ships (MASS) do not consider the various forces acting on ships in real sea conditions. Addressing this gap, researchers developed a novel time-optimal control method, that accounts for the real wave loads acting on a ship, enabling effective planning and control of MASS at sea.
Published Simple trick could improve accuracy of plant genetics research
(via sciencedaily.com) Original source Researchers have published a simple trick that improves the accuracy of techniques that help us understand how external variables -- such as temperature -- affect gene activity in plants.
Published Milk to the rescue for diabetics? Cow produces human insulin in milk
(via sciencedaily.com) Original source An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.
Published A simple and robust experimental process for protein engineering
(via sciencedaily.com) Original source A protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins will be effective for a given purpose, according to a new study.