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Categories: Biology: Genetics, Mathematics: Modeling
Published 200-year-old DNA helps map tiny fly's genetic course to new lands, modern times
(via sciencedaily.com) Original source Researchers have extracted and analyzed DNA from fruit flies housed in museum collections in Lund, Stockholm and Copenhagen. Surprisingly, the researchers found the fruit flies collected in Sweden in the early 1800s were more genetically similar to 21st century flies than the Swedish samples from the 1930s.
Published Scientists generate first single-cell 'atlas' of the primate brain to help explore links between molecules, cells, brain function and disease
(via sciencedaily.com) Original source As part of the effort to better understand the evolution of the brains in people and animals, a research team has generated the world's largest primate brain-wide atlas.
Published Scientists unveil detailed cell maps of the human brain and the nonhuman primate brain
(via sciencedaily.com) Original source A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain. This understanding of brain structure allows for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.
Published Honey bees may inherit altruistic behavior from their mothers
(via sciencedaily.com) Original source True altruism is rare behavior in animals, but a new study has found that honey bees display this trait. Additionally, they found that an evolutionary battle of genetics may determine the parent they inherit it from.
Published Win-win in muscle research: Faster results and fewer laboratory animals thanks to new method
(via sciencedaily.com) Original source To study muscle diseases, scientists rely on the mouse as a model organism. Researchers have now developed a new method that is not only faster and more efficient than conventional ones but also greatly reduces the number of experimental animals needed for studying the function of genes in muscle fibers.
Published New organ-on-a-chip model of human synovium could accelerate development of treatments for arthritis
(via sciencedaily.com) Original source The synovium is a membrane-like structure that lines the knee joint and helps to keep the joint happy and healthy, mainly by producing and maintaining synovial fluid. Inflammation of this tissue is implicated in the onset and progression of arthritic diseases such as rheumatoid and osteoarthritis. Therefore, treatments that target the synovium are promising in treating these diseases. However, we need better models in the laboratory that allow us to find and test new treatments. We have developed an organ-on-a-chip based model of the human synovium, and its associated vasculature, to address this need.
Published Omega-3 discovery moves us closer to 'precision nutrition' for better health
(via sciencedaily.com) Original source Researchers have obtained new insights into how African-American and Hispanic-American people’s genes influence their ability to use Omega-3 and Omega-6 fatty acids for good health. The findings are an important step toward “precision nutrition” – where a diet tailored to exactly what our bodies need can help us live longer, healthier lives.
Published A step towards AI-based precision medicine
(via sciencedaily.com) Original source Artificial intelligence, AI, which finds patterns in complex biological data could eventually contribute to the development of individually tailored healthcare. Researchers have developed an AI-based method applicable to various medical and biological issues. Their models can for instance accurately estimate people's chronological age and determine whether they have been smokers or not.
Published Doubling down on known protein families
(via sciencedaily.com) Original source A massive computational analysis of microbiome datasets has more than doubled the number of known protein families. This is the first time protein structures have been used to help characterize the vast array of microbial 'dark matter.'
Published Death is only the beginning: Birds disperse eaten insects' eggs
(via sciencedaily.com) Original source Relationship patterns among flightless stick insects suggest that birds disperse the eggs after eating gravid females. Lab experiments previously suggested the possibility, but a new genetic analysis of natural populations in Japan now supports the idea.
Published What is the impact of predictive AI in the health care setting?
(via sciencedaily.com) Original source Models built on machine learning in health care can be victims of their own success, according to researchers. Their study assessed the impact of implementing predictive models on the subsequent performance of those and other models.
Published Newfound mechanism suggests drug combination could starve pancreatic cancer
(via sciencedaily.com) Original source A study found that a new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for fuel.
Published Epigenetic regulator MOF drives mitochondrial metabolism
(via sciencedaily.com) Original source Researchers have unveiled a new mechanism for regulating mitochondrial function. The findings reveal the critical role played by the enzymatic activity of the lysine acetyltransferase MOF in maintaining mitochondrial integrity and function through acetylation of mitochondrial electron transport chain component COX17. Cells lacking MOF-mediated COX17 acetylation exhibit dramatic mitochondrial defects and impaired ability to produce energy. Underscoring the clinical relevance of these findings, the team also showed that cells from human patients with a developmental disorder caused by mutations in MOF also exhibited respiratory defects that could be ameliorated by interventions such as acetylation-mimetic COX17 or mitochondrially targeted MOF.
Published AI language models could help diagnose schizophrenia
(via sciencedaily.com) Original source Scientists have developed new tools, based on AI language models, that can characterize subtle signatures in the speech of patients diagnosed with schizophrenia.
Published Researchers create a neural network for genomics -- one that explains how it achieves accurate predictions
(via sciencedaily.com) Original source A team of computer scientists has created a neural network that can explain how it reaches its predictions. The work reveals what accounts for the functionality of neural networks--the engines that drive artificial intelligence and machine learning--thereby illuminating a process that has largely been concealed from users.
Published How male mosquitoes compensate for having only one X chromosome
(via sciencedaily.com) Researchers have discovered the master regulator responsible for balancing the expression of X chromosome genes between males and females in the malaria mosquito. This discovery helps scientists better understand the evolution of the epigenetic mechanisms responsible for equalizing gene expression between the sexes. The findings may contribute to the development of new ways to prevent the spread of malaria.
Published Natural GM crops: Grasses take evolutionary shortcut by borrowing genes from their neighbors
(via sciencedaily.com) Original source Grass may transfer genes from their neighbors in the same way genetically modified crops are made, a new study has revealed.
Published New discovery may 'unlock' the future of infectious disease and cancer treatment
(via sciencedaily.com) Original source Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.
Published The end of genes: Routine test reveals unique divergence in genetic code
(via sciencedaily.com) Original source Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics. The genome of a protist has revealed a seemingly unique divergence in the DNA code signalling the end of a gene, suggesting the need for further research to better understand this group of diverse organisms.
Published New open-source method to improve decoding of single-cell data
(via sciencedaily.com) Original source Researchers have developed a new open-source computational method, dubbed Spectra, which improves the analysis of single-cell transcriptomic data. By guiding data analysis in a unique way, Spectra can offer new insights into the complex interplay between cells — like the interactions between cancer cells and immune cells, which are critical to improving immunotherapy treatments.