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Published

New computational strategy boosts the ability of drug designers to target proteins inside the membrane      (via sciencedaily.com)     Original source 

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, chemists have demonstrated new custom-designed proteins that can efficiently reach these 'intramembrane' targets.

Biology: Biochemistry Biology: Biotechnology Biology: Botany Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Ecology: Endangered Species
Published

Simple trick could improve accuracy of plant genetics research      (via sciencedaily.com)     Original source 

Researchers have published a simple trick that improves the accuracy of techniques that help us understand how external variables -- such as temperature -- affect gene activity in plants.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Offbeat: General Offbeat: Plants and Animals
Published

Milk to the rescue for diabetics? Cow produces human insulin in milk      (via sciencedaily.com)     Original source 

An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Chemistry: Biochemistry Chemistry: General Chemistry: Organic Chemistry
Published

A simple and robust experimental process for protein engineering      (via sciencedaily.com)     Original source 

A protein engineering method using simple, cost-effective experiments and machine learning models can predict which proteins will be effective for a given purpose, according to a new study.

Biology: Biochemistry Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Scientists find weak points on Epstein-Barr virus      (via sciencedaily.com)     Original source 

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

How a natural compound from sea squirts combats cancer      (via sciencedaily.com)     Original source 

Trabectedin, a promising drug derived from the sea squirt Ecteinascidia turbinata, has shown potential in combating cancers resistant to conventional treatments. However, its precise mechanism of action has remained elusive -- until now.

Biology: Botany Biology: General Ecology: General Ecology: Invasive Species Ecology: Nature Ecology: Research Ecology: Trees Environmental: Biodiversity Environmental: Ecosystems Environmental: General
Published

Rainforest's next generation of trees threatened 30 years after logging      (via sciencedaily.com)     Original source 

Rainforest seedlings are more likely to survive in natural forests than in places where logging has happened -- even if tree restoration projects have taken place, new research shows.

Biology: Biochemistry Ecology: Research Paleontology: Dinosaurs Paleontology: General
Published

Higher carnivorous dinosaur biodiversity of famous Kem Kem beds, Morocco      (via sciencedaily.com)     Original source 

An international team of palaeontologists applied recently developed methods to measure theropod (carnivorous) dinosaur species diversity. The newly applied method uses both traditional phylogenetic analysis, discriminant analysis as well as machine learning.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Zoology Ecology: Extinction Environmental: General
Published

New study reveals transgenerational effects of pesticide linuron on frogs      (via sciencedaily.com)     Original source 

Grand-offspring of male frogs exposed to the pesticide linuron exhibited changes in their DNA that was linked to significant physiological impacts, a study reveals. The research highlights the profound transgenerational consequences of environmental pollution on amphibian populations, which are already under threat of extinction.

Biology: Biochemistry Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Researchers uncover protein responsible for cold sensation      (via sciencedaily.com)     Original source 

Researchers have identified the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of sensory biology.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Molecular Biology: Zoology
Published

Research sheds light on new strategy to treat infertility      (via sciencedaily.com)     Original source 

New research describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos. The technique could be used by women of advanced maternal age or for those who are unable to produce viable eggs due to previous treatment for cancer or other causes. It also raises the possibility of men in same-sex relationships having children who are genetically related to both parents.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

New study discovers how altered protein folding drives multicellular evolution      (via sciencedaily.com)     Original source 

Researchers have discovered a mechanism steering the evolution of multicellular life. They identified how altered protein folding drives multicellular evolution.

Biology: Marine Ecology: Extinction Ecology: General Ecology: Research Ecology: Sea Life Environmental: Ecosystems
Published

Good news for coral reef restoration efforts: Study finds 'full recovery' of reef growth within four years      (via sciencedaily.com)     Original source 

While the majority of the world's reefs are now under threat or even damaged potentially beyond repair, a new study offers some encouraging news: efforts to restore coral reefs not only increase coral cover, but they can also bring back important ecosystem functions, and surprisingly fast.

Biology: Biochemistry Biology: General Biology: Zoology Ecology: Animals Ecology: Endangered Species Ecology: Extinction Ecology: General Ecology: Invasive Species Ecology: Nature Ecology: Research Environmental: Biodiversity
Published

Reptile roadkill reveals new threat to endangered lizard species      (via sciencedaily.com)     Original source 

The chance sighting of a dead snake beside a sandy track in remote Western Australia, and the investigation of its stomach contents, has led researchers to record the first known instance of a spotted mulga snake consuming a pygmy spiny-tailed skink, raising concerns for a similar-looking, endangered lizard species.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Molecular
Published

Vitamin A may play a central role in stem cell biology and wound repair      (via sciencedaily.com)     Original source 

Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Zoology
Published

How does a virus hijack insect sperm to control disease vectors and pests?      (via sciencedaily.com)     Original source 

A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus. A new study has uncovered how this microbial combination manipulates sperm, which could lead to refined techniques to control populations of agricultural pests and insects that carry diseases like Zika and dengue to humans.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

The Malaria parasite generates genetic diversity using an evolutionary 'copy-paste' tactic      (via sciencedaily.com)     Original source 

All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.