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Categories: Biology: Genetics, Ecology: Extinction

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Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.

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Birds across the Americas are getting smaller and longer-winged as the world warms, and the smallest-bodied species are changing the fastest.

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Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.

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New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.

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Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.

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Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.

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Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.

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Automation uncovers combinations of amino acids that feed two bacterial species and could tell us much more about the 90% of bacteria that humans have hardly studied. An artificial intelligence system enables robots to conduct autonomous scientific experiments -- as many as 10,000 per day -- potentially driving a drastic leap forward in the pace of discovery in areas from medicine to agriculture to environmental science.

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Phytosterols are good for your health, but humans and other animals are not able to make them themselves, only plants can. To acquire phytosterols, humans are increasingly turning to supplements, green smoothies, or a Mediterranean diet with plenty of plant-based foods. Researchers have now discovered that tiny gutless worms from the Mediterranean can synthesize phytosterols on their own. Their study provides evidence that many other animals also have the genes needed to make their own phytosterols.

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Researchers discover a unique two-component molecular motor that uses a kind of renewable chemical energy to pull vesicles toward membrane-bound organelles.

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For decades, scientists have used the amount of seaweed at the ocean's surface as a proxy for the health of coral reefs below. However, a new global study of more than 1,200 marine locations over a 16-year period reveals that this approach has been misleading -- and may even have hidden signs of reef stress.

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Most chromosomes have been around for millions of years. Now, researchers have revealed the dynamics of a new, very young chromosome in fruit flies that is similar to chromosomes that arise in humans and is associated with treatment-resistant cancer and infertility. The findings may one day lead to developing more targeted therapies for treating these conditions.

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In the face of global warming and other environmental changes, corals in the Atlantic Ocean have declined precipitously in recent years, while corals in the Pacific and Indian Oceans are faring better. By describing several species of symbiotic algae that these corals need to grow, an international team has found that these mutualistic relationships from the Indo-Pacific may be more flexible and ultimately resilient to higher ocean temperatures than those in the Atlantic.

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A team of researchers develops stem cell adhesive for arthritis treatment using mussel adhesion protein and hyaluronic acid.

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Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.

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Like animals, many plant species are struggling to adapt to a human-dominated planet. However, plants are often overlooked in conservation efforts, even though they are cheaper and easier to protect than animals and play a pivotal role in bolstering our food, fuel, and medical systems. A plant ecologist suggests an approach for preventing all future land plant extinctions across the globe which includes training more plant experts, building an online 'metaherbarium,' and creating 'microreserves.'

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Dynamic network in the pores of the nuclear envelope blocks dangerous invaders.

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Scientists from around the globe are using the largest mammalian genomic dataset in history to determine the evolutionary history of the human genome in the context of mammalian evolutionary history. Their ultimate goal is to better identify the genetic basis for traits and diseases in people and other species.

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Ensuring the supply of food to the constantly growing world population and protecting the environment at the same time are often conflicting objectives. Now researchers have successfully developed a method for the synthetic manufacture of a nutritional protein using a type of artificial photosynthesis. The animal feed industry is the primary driver of high demand for large volumes of this nutritional protein L-alanine, which is also suitable for use in meat substitute products.

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A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.