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Categories: Biology: Genetics, Space: Cosmology

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The effects of coffee consumption on human health is a knotty question, but one thing is sure: coffee is a psychoactive substance.

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An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.

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Formation of the body axes is a critical part of embryonic development. They guarantee that all body parts end up where they belong and that no ears grow on our backs. The head-tail axis, for example, determines the orientation of the two ends of the body. It was previously assumed that this axis is largely determined by the interplay between the Nodal and BMP signals. However, there appears to be another player in this system, as researchers have now discovered by using an embryo-like model system they developed. In the absence of BMP, the signalling molecule beta-catenin takes on the role of the Nodal antagonist. This new mechanism could be a flexible solution for axis formation in embryos with different shapes.

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The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice. While uncovering how the high fat, low carbohydrate diet boosts memory in older mice, scientists identified a new molecular signaling pathway that improves synapse function and helps explain the diet's benefit on brain health and aging.

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Using a specially designed 3D printed vacuum system, scientists have developed a way to 'trap' dark matter with the aim of detecting domain walls, this will be a significant step forwards in unravelling some of the mysteries of the universe.

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A decade-long study has discovered huge genetic potential that is untapped in modern wheat varieties.

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Astronomers have discovered a double-record-breaking pair of quasars. Not only are they the most distant pair of merging quasars ever found, but also the only pair confirmed in the bygone era of the Universe's earliest formation.

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In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.

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Climate change is making it more difficult to raise cattle -- growth and reproduction are affected by heat -- so it's critical to breed cattle better adapted to a hotter and longer summer. A new study shows it's possible to identify the genes within breeds of cattle that would lead to the sweatiest, heat-tolerant offspring.

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Researchers have experimentally generated high-density relativistic electron-positron pair-plasma beams by producing two to three orders of magnitude more pairs than previously reported.

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Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life. The genetic basis for these exceptional abilities remains elusive. Researchers have now successfully edited genes using the CRISPR technique in a highly resilient tardigrade species previously impossible to study with genome-editing tools. The successful delivery of CRISPR to an asexual tardigrade species directly produces gene-edited offspring. The design and editing of specific tardigrade genes allow researchers to investigate which are responsible for tardigrade resilience and how such resilience can work.

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Researchers used supercomputers to create nearly 4 million simulated images depicting the cosmos.

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Researchers have found that germ cells, which develop into eggs and sperm, drive sex-dependent differences in lifespan in vertebrates. Female and male germ cells increase and reduce lifespan, respectively. These effects are controlled via estrogen and growth factor hormones in females and vitamin D in males. Vitamin D supplementation extends lifespan in both males and females. The results clarify the link between reproduction and aging and show that vitamin D may improve longevity in vertebrates.

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Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer. Now, a new study introduces an original technique, called HiDEF-seq, that can accurately detect the early molecular changes in DNA code that precede mutations.

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Clouds of gas in a distant galaxy are being pushed faster and faster -- at more than 10,000 miles per second -- out among neighboring stars by blasts of radiation from the supermassive black hole at the galaxy's center. It's a discovery that helps illuminate the way active black holes can continuously shape their galaxies by spurring on or snuffing out the development of new stars.

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By combining forefront X-ray observations with state-of-the-art supercomputer simulations of the buildup of galaxies over cosmic history, researchers have provided the best modeling to date of the growth of the supermassive black holes found in the centers of galaxies.

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Using tools of modern genetics, plant biochemists have produced a new high-yielding oilseed crop variety -- a yellow-seeded variety of Camelina sativa, a close relative of canola, that accumulates 21.4% more oil than ordinary camelina.

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Scientists are peering into the past and uncovering new clues about the early universe. Since light takes a long time to travel through space, they are now able to see how galaxies looked billions of years ago. The astronomers have discovered that spiral galaxies were more common in the early universe than previously thought. The scientists found that nearly 30% of galaxies have a spiral structure about 2 billion years after the universe formed. The discovery provides a significant update to the universe's origin story as previously told using data from NASA's Hubble Space Telescope.

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Researchers have discovered that virus-like nanoparticles can promote the multicellular organization and reproduction of host bacteria. These particles, which are evolutionarily related to phages (viruses that infect bacteria), contain an enzyme that helps shape the multicellular architecture and ultimately enhances morphological differentiation.

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What scientists previously thought about where Fast Radio Bursts (FRBs) come from is just the tip of the iceberg. A new study details the properties of polarized light from 128 non-repeating FRBs and reveals mysterious cosmic explosions that originated in far-away galaxies, similar to our own Milky Way.