Showing 20 articles starting at article 981
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Categories: Biology: Genetics, Space: Cosmology
Published A channel involved in pain sensation can also suppress it
(via sciencedaily.com) Original source Pain is good. It's the body's way to keep an animal from harming itself or repeating a dangerous mistake. But sometimes the debilitating sensation can get in the way. So evolution has devised ways to tamp that response down under certain circumstances.
Published Researchers reveal DNA repair mechanism
(via sciencedaily.com) Original source A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.
Published How superbug A. baumannii survives metal stress and resists antibiotics
(via sciencedaily.com) Original source The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response. The World Health Organization (WHO) recognizes it as one of the three top pathogens in critical need of new antibiotic therapies. Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published this month in Nucleic Acids Research.
Published Phage structure captured, to benefit biotech applications
(via sciencedaily.com) Original source Researchers have mapped out what a commonly-used form of phage looks like, which will help design better uses in future.
Published Researcher uses mammal DNA to zoom into the human genome with unprecedented resolution
(via sciencedaily.com) Original source Scientists have precisely identified base pairs of the human genome that remained consistent over millions of years of mammalian evolution, and which play a crucial role in human disease. The team analyzed the genomes of 240 mammals, including humans and identified base pairs that were 'constrained' -- meaning they remained generally consistent -- across mammal species over the course of evolution. The most constrained base pairs in mammals were over seven times more likely to be causal for human disease and complex trait, and over 11 times more likely when researchers looked at the most constrained base pairs in primates alone.
Published Astronomers reveal the largest cosmic explosion ever seen
(via sciencedaily.com) Original source Astronomers have uncovered the largest cosmic explosion ever witnessed. The explosion is more than ten times brighter than any known supernova and three times brighter than the brightest tidal disruption event, where a star falls into a supermassive black hole.
Published A look inside stem cells helps create personalized regenerative medicine
(via sciencedaily.com) Original source Researchers have examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.
Published Researchers find new approach to explore earliest universe dynamics with gravitational waves
(via sciencedaily.com) Original source Researchers have discovered a new generic production mechanism of gravitational waves generated by a phenomenon known as oscillons.
Published Ancestral mitoviruses discovered in mycorrhizal fungi
(via sciencedaily.com) Original source A new group of mitochondrial viruses confined to the arbuscular mycorrhizal fungi Glomeromycotina may represent an ancestral lineage of mitoviruses.
Published Hidden supermassive black holes brought to life by galaxies on collision course
(via sciencedaily.com) Original source Astronomers have found that supermassive black holes obscured by dust are more likely to grow and release tremendous amounts of energy when they are inside galaxies that are expected to collide with a neighbouring galaxy.
Published Celestial monsters at the origin of globular clusters
(via sciencedaily.com) Original source Globular clusters are the most massive and oldest star clusters in the Universe. They can contain up to 1 million of them. The chemical composition of these stars, born at the same time, shows anomalies that are not found in any other population of stars. Explaining this specificity is one of the great challenges of astronomy. After having imagined that supermassive stars could be at the origin, a team believes it has discovered the first chemical trace attesting to their presence in globular proto-clusters, born about 440 million years after the Big Bang.
Published New research could help breed for less 'spooky' horses
(via sciencedaily.com) Original source Researchers are working to identify genes that influence horses' tendency to react to perceived danger.
Published Measurement of the Universe's expansion rate weighs in on a longstanding debate in physics and astronomy
(via sciencedaily.com) Original source A team used a first-of-its-kind technique to measure the expansion rate of the Universe, providing insight that could help more accurately determine the Universe's age and help physicists and astronomers better understand the cosmos.
Published Crops evolved by swapping genetic modules between cells
(via sciencedaily.com) Original source Comparing individual cells across corn, sorghum, and millet reveals evolutionary differences among these important cereal crops, according to a new study. The findings bring researchers closer to pinpointing which genes control important agricultural traits such as drought tolerance, which will help scientists faced with a changing climate adapt crops to drier environments.
Published Scientists develop gene silencing DNA enzyme that can target a single molecule
(via sciencedaily.com) Original source Researchers have developed a DNA enzyme -- or DNAzyme -- that can distinguish between two RNA strands inside a cell and cut the disease-associated strand while leaving the healthy strand intact. This breakthrough 'gene silencing' technology could revolutionize the development of DNAzymes for treating cancer, infectious diseases and neurological disorders.
Published T cells can activate themselves to fight tumors
(via sciencedaily.com) Original source Scientists find an auto-signaling mechanism driving the T cell anti-tumor response; findings may inspire new cancer therapeutics and biomarkers.
Published New probe aids novel findings on cell functions
(via sciencedaily.com) Original source New research shows the use of a new cellular probe helped discover new findings about certain cellular processes.
Published An unprecedented view of gene regulation
(via sciencedaily.com) Original source Using a new technique, researchers have shown that they can map interactions between gene promoters and enhancers with 100 times higher resolution than has previously been possible.
Published Elucidating the mysteries of enzyme evolution at the macromolecular level
(via sciencedaily.com) Original source Researchers have made a major breakthrough earlier this year in the field of evolutionary conservation of molecular dynamics in enzymes. Their work points to potential applications in health, including the development of new drugs to treat serious diseases such as cancer or to counter antibiotic resistance.
Published Scientist uncovers roots of antibiotic resistance
(via sciencedaily.com) Original source Microbiologists have uncovered the evolutionary origins of antimicrobial resistance (AMR) in bacteria. His studies on the bacterium that causes cholera, Vibrio cholerae, provide insight into deciphering what conditions must occur for infectious agents to become resistant. He studied genetic variants of a protein found in bacterial membranes called OmpU. Using computational and molecular approaches, his team found that several OmpU mutations in the cholera bacteria led to resistance to numerous antimicrobial agents. This resistance included antimicrobial peptides that act as defenses in the human gut.