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Categories: Biology: Genetics, Ecology: Sea Life
Published New, modified CRISPR protein can fit inside virus used for gene therapy
(via sciencedaily.com) Original source Researchers have developed a novel version of a key CRISPR gene-editing protein that shows efficient editing activity and is small enough to be packaged within a non-pathogenic virus that can deliver it to target cells.
Published Novel virus identified in zebrafish from the pet trade causes disease in laboratory fish
(via sciencedaily.com) Original source Zebrafish in the pet trade are asymptomatic carriers of previously undescribed microbes, including a novel virus that causes hemorrhaging in infected laboratory fish, researchers report.
Published Researchers expose new symbiosis origin theories, identify experimental systems for plant life
(via sciencedaily.com) Original source Research work on symbiosis -- a mutually beneficial relationship between living organisms -- is pushing back against the newer theory of a 'single-origin' of root nodule symbiosis (RNS) -- that all symbiosis between plant root nodules and nitrogen-fixing bacteria stems from one point--instead suggesting a 'multiple-origin' theory of sybiosis which opens a better understanding for genetically engineering crops.
Published Researchers apply quantum computing methods to protein structure prediction
(via sciencedaily.com) Original source Researchers recently published findings that could lay the groundwork for applying quantum computing methods to protein structure prediction.
Published hnRNPM, a guardian of the integrity of cellular protein production
(via sciencedaily.com) Original source Researchers have discovered that the protein hnRNPM prevents the cell from making mistakes while it is producing new proteins, which helps maintain the integrity of this vital process.
Published Editing without 'cutting': Molecular mechanisms of new gene-editing tool revealed
(via sciencedaily.com) Original source New research has determined the spatial structure of various processes of a novel gene-editing tool called 'prime editor.' Functional analysis based on these structures also revealed how a 'prime editor' could achieve reverse transcription, synthesizing DNA from RNA, without 'cutting' both strands of the double helix. Clarifying these molecular mechanisms contributes greatly to designing gene-editing tools accurate enough for gene therapy treatments.
Published Chicken feathers to deliver chemotherapy drugs and repair enzymes
(via sciencedaily.com) Original source A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.
Published Complete X and Y chromosome sequences of living great ape species determined
(via sciencedaily.com) Original source Newly generated, complete genomes for the sex chromosomes of six primate species may inform conservation of these endangered species and shed light on sex-related genetic diseases in both humans and our closest living relatives.
Published Researchers improve satellite surveillance of emperor penguins
(via sciencedaily.com) Original source New phenological and behavioral models will help scientists collect more accurate counts of emperor penguins. Emperor penguins are at the top of the food web. They are a reflection of how lower levels of the marine food web are being impacted by climate change. Systematic data collection on the biological component of ecosystems is still in its infancy, especially in harsh environments, in which consistent and repeatable research is particularly hard to achieve.
Published Some species may tolerate climate change better than expected
(via sciencedaily.com) Original source A new model reassesses the proportion of terrestrial and marine species threatened with extinction by climate change. While the forecasts of traditional models estimate that the diversity of terrestrial species in tropical areas could decrease by 54% between now and 2041-2060, this model is more moderate, predicting a decrease of 39%. Nevertheless, this proportion remains alarming and confirms the importance of taking urgent measures to mitigate climate change and its impact on biodiversity.
Published Marine Protected Areas don't line up with core habitats of rare migratory fish, finds new research
(via sciencedaily.com) Original source 62% of Marine Protected Areas (MPAs) designated to protect rare migratory fish species are outside of their core habitats, according to a new modeling study.
Published Scientists identify gene that could lead to resilient 'pixie' corn
(via sciencedaily.com) Original source A widely found gene in plants has been newly identified as a key transporter of a hormone that influences the size of corn. The discovery offers plant breeders a new tool to develop desirable dwarf varieties that could enhance the crop's resilience and profitability.
Published The secret sex life of coral revealed
(via sciencedaily.com) Original source Corals play an essential role in ocean ecosystems, and like many organisms, they are under threat from climate change and other human activities. To better protect coral, it's first necessary to understand them, in particular their reproductive life cycle, which only happens once a year. For the first time, researchers have produced a model for coral spawning, based on various environmental factors. They achieved this by tapping an often overlooked source of aquatic knowledge, an aquarium.
Published Bringing back an ancient bird
(via sciencedaily.com) Original source Using ancient DNA extracted from the toe bone of a museum specimen, biologists have sequenced the genome of an extinct, flightless bird called the little bush moa, shedding light into an unknown corner of avian genetic history. The work is the first complete genetic map of the turkey-sized bird whose distant living cousins include the ostrich, emu, and kiwi.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published 'Cloaked' proteins deliver cancer-killing therapeutics into cells
(via sciencedaily.com) Original source Scientists have designed a way to 'cloak' proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published How killifish embryos use suspended animation to survive over 8 months of drought
(via sciencedaily.com) Original source The African turquoise killifish lives in ephemeral ponds in Zimbabwe and Mozambique. To survive the annual dry season, the fish's embryos enter a state of extreme suspended animation or 'diapause' for approximately 8 months. Now, researchers have uncovered the mechanisms that enabled the killifish to evolve this extreme survival state.
Published Global activity of seafloor biodiversity mapped
(via sciencedaily.com) Original source A team of scientists has used artificial intelligence (AI) to map the activities of seafloor invertebrate animals, such as worms, clams and shrimps, across all the oceans of the world.
Published Investigating the origin of circatidal rhythms in freshwater snails
(via sciencedaily.com) Original source While most organisms have biological clocks synchronized with the day-night cycle (circadian rhythms), marine animals in tidal areas have also developed circatidal rhythms to align with the tidal cycle. Comparing the activity and genetic expression of snails from tidal and non-tidal areas, researchers demonstrate that circatidal rhythms develop as snails adapt to tidal environments. These findings highlight the flexibility of biological clocks, enabling organisms to adjust their rhythms according to the environment.