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Categories: Biology: General, Biology: Genetics
Published Flu virus variants resistant to new antiviral drug candidate lose pathogenicity
(via sciencedaily.com) Original source Influenza A viruses with induced resistance to a new candidate antiviral drug were found to be impaired in cell culture and weakened in animals, according to a new study.
Published Extra fingers and hearts: Pinpointing changes to our genetic instructions that disrupt development
(via sciencedaily.com) Original source Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.
Published How T cells combat tuberculosis
(via sciencedaily.com) Original source Scientists have uncovered important clues to how human T cells combat Mycobacterium tuberculosis, the bacterium that causes TB.
Published New species of Jurassic pterosaur discovered on the Isle of Skye
(via sciencedaily.com) Original source A new species of pterosaur from specimens found on the Isle of Skye, Scotland, has been announced.
Published Mystery of moths' warning sound production explained in new study
(via sciencedaily.com) Original source The workings of the ultrasonic warning sounds produced by the wings of a species of moth have been revealed.
Published A rare recent case of retrovirus integration: An infectious gibbon ape leukaemia virus is colonizing a rodent's genome in New Guinea
(via sciencedaily.com) Original source Retroviruses are viruses that multiply by incorporating their genes into the genome of a host cell. If the infected cell is a germ cell, the retrovirus can then be passed on to the next generation as an 'endogenous' retrovirus (ERV) and spread as part of the host genome in that host species. In vertebrates, ERVs are ubiquitous and sometimes make up 10 per cent of the host genome. However, most retrovirus integrations are very old, already degraded and therefore inactive -- their initial impact on host health has been minimized by millions of years of evolution. A research team has now discovered a recent case of retrovirus colonization in a rodent from New Guinea, the white-bellied mosaic-tailed rat.
Published Down to the core of poxviruses
(via sciencedaily.com) Original source A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat, underlining an important knowledge gap at their core. Now, a team of researchers lifted the mysteries of poxviral core architecture by combining various cryo-electron microscopy techniques with molecular modeling.
Published Computer-engineered DNA to study cell identities
(via sciencedaily.com) Original source A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.
Published Smells like evolution: Fruit flies reveal surprises in chemical sensing
(via sciencedaily.com) Original source New study reveals how gene expression shapes the diverse smelling and tasting abilities of different fly species. Most genes are surprisingly stable, but thousands have evolved to create unique olfactory landscapes. Sex differences in sensing are widespread and involve specific cell types in key tissues. The study provides insights into the evolution of sensory systems in general, with potential implications for understanding human olfaction.
Published Microbial division of labor produces higher biofuel yields
(via sciencedaily.com) Original source Scientists have found a way to boost ethanol production via yeast fermentation, a standard method for converting plant sugars into biofuels. Their approach relies on careful timing and a tight division of labor among synthetic yeast strains to yield more ethanol per unit of plant sugars than previous approaches have achieved.
Published Small but mighty -- study highlights the abundance and importance of the ocean's tiniest inhabitants
(via sciencedaily.com) Original source New research sheds light on tiny plankton, which measure less than 0.02mm in diameter but can make up more than 70% of the plankton biomass found in the ocean.
Published How food availability could catalyze cultural transmission in wild orangutans
(via sciencedaily.com) Original source The proverb "necessity is the mother of invention" has been used to describe the source from which our cultural evolution springs. After all, need in times of scarcity has forced humans to continually invent new technologies that have driven the remarkable cumulative culture of our species. But an invention only becomes cultural if it is learned and spread by many individuals. In other words, the invention must be socially transmitted. But what are the forces that drive social transmission?
Published Vitamin B12 adaptability in Antarctic algae has implications for climate change, life in the Southern Ocean
(via sciencedaily.com) Original source The algae P. antarctica has two forms of the enzyme that makes the amino acid methionine, one needing B12, and one that is slower, but doesn't need it. This means it has the ability to adapt and survive with low B12 availability. The presence of the MetE gene in P. antarctica gives the algae the ability to adapt to lower vitamin B12 availability, giving it a potential advantage to bloom in the early austral spring when bacterial production is low. P. antarctica takes in the CO2 and releases oxygen through photosynthesis. Understanding its ability to grow in environments with low vitamin B12 availability can help climate modelers make more accurate predictions.
Published New technology unscrambles the chatter of microbes
(via sciencedaily.com) Original source Researchers have developed a new search tool to that can match microbes to the metabolites they produce with no prior knowledge, an innovation that could transform our understanding of both human health and the environment.
Published Scientists see an ultra-fast movement on surface of HIV virus
(via sciencedaily.com) Original source Seeing a glycoprotein on the envelope of the HIV virus snap open and shut in mere millionths of a second is giving investigators a new handle on the surface of the virus that could lead to broadly neutralizing antibodies for an AIDS vaccine. Being able to attach an antibody specifically to this little structure that would prevent it from popping open would be key.
Published Mechanism discovered that protects tissue after faulty gene expression
(via sciencedaily.com) Original source A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.
Published Scammed! Animals 'led by the nose' to leave plants alone
(via sciencedaily.com) Original source Fake news works for wallabies and elephants. Herbivores can cause substantial damage to crops or endangered or protected plants, with traditional methods to deter foraging lethal, expensive or ineffective. Biologists are now using aromas from plants naturally repellent with remarkable success to deter the animals.
Published How leafcutter ants cultivate a fungal garden to degrade plants and provide insights into future biofuels
(via sciencedaily.com) Original source Scientists developed a new method to map exactly how a fungus works with leafcutter ants in a complex microbial community to degrade plant material at the molecular level. The team's insights are important for biofuels development.
Published Disrupted cellular function behind type 2 diabetes in obesity
(via sciencedaily.com) Original source Disrupted function of 'cleaning cells' in the body may help to explain why some people with obesity develop type 2 diabetes, while others do not. A study describes this newly discovered mechanism.
Published A clutch stretch goes a long way
(via sciencedaily.com) Original source New results reveal a new mode of force transmission in which dynamic molecular stretching bridges the extracellular matrix and flowing F-actin moving at different speeds. This discovery underscores the necessity of molecular elasticity and random coupling for sufficiently transmitting force. The findings also call for revising the role of molecular unfolding.