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Categories: Biology: Genetics, Biology: Zoology

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Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient. Now, researchers have developed a machine-learning approach that promises to speed up AAV engineering for gene therapy. The tool helps researchers engineer the protein shells of AAVs, called capsids, to have multiple desirable traits, such as the ability to deliver cargo to a specific organ but not others or to work in multiple species. Other methods only look for capsids that have one trait at a time.

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A 'loopy' discovery in bacteria is raising fundamental questions about the makeup of our own genome -- and revealing a potential wellspring of material for new genetic therapies.

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A new artificial intelligence model can predict how different proteins may bind to DNA.

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The need for a dramatic selfie or the perfect landscape photo is proving detrimental to nature, a new research collaboration has found.

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The key finding was that temperature and genome size, not body size, had the greatest influence on the maximum population growth rate of the diatoms. Yet body size still mattered in colder latitudes, conserving Bermann's Rule.

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Scientists have developed a new way of counting labelled proteins in living cells that could become a standard and valuable tool in the field of biomedical research.

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As our climate changes and soil salinity increases in many agricultural areas, finding crops that can thrive in these challenging conditions is crucial. Cultivated tomatoes, while delicious, often struggle in salty soils. Their wild cousins, however, have evolved to survive in diverse and often harsh environments. A recent study delved into the genetic treasure trove of wild tomatoes to uncover secrets of salt tolerance that could be used to develop resilient crop varieties.

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There comes a point in the lives of young owl monkeys when they leave their parents and strike out on their own to find a mate. In a new study of a wild population of Azara's owl monkeys in northern Argentina, researchers reveal that a combination of social and ecological factors influences when these tree-dwelling monkeys peel away from their parents and siblings. According to their findings -- which were based on 25 years of genetic and demographic data for several generations of owl monkeys, covering more than 330 individuals -- none of the individuals, regardless of their sex, reproduced in the same group where they were born. In all cases, the researchers found, the animals either departed from their natal group or died before reproducing.

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Scientists discovered a role played by ribosomes during the folding of new proteins in cells.

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A viral defense mechanism can be used to accelerate the creation of female stem cell lines in mice. The findings can boost efforts in medical research, drug testing, and regenerative therapies, particularly for women and individuals with two X chromosomes.

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Researchers have discovered two proteins that work in tandem to control an important response to cell stress.

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The pterosaur likely used all four limbs to propel itself in the air, as seen in bats today, researchers have found.

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Populations of squaretail grouper face an uncertain future as new research shows fishing that targets their spawning sites is causing males to be repeatedly scared away from their territories during their short mating meet-ups. By fleeing for safety, individuals are losing valuable time to catch the eye and court female fish.

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Pesticides and herbicides are critical to ensuring food security worldwide, but these substances can present a safety risk to people who unwittingly ingest them. Protecting human health, therefore, demands sensitive analytical methods to identify even trace levels of potentially harmful substances. Now, researchers have developed a high-tech imaging method to detect pesticide contamination at low levels, and its application on fruits reveals that current food safety practices may be insufficient.

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Fruit exist to invite animals to disperse the swallowed seeds. A research team found that plants targeting insects rather than birds or mammals for this service are more common than previously thought. These plants produce dust-like seeds and fruit suitable for the minute, ground-dwelling animals.

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Elephant conservation is a major priority in southern Africa, but habitat loss and urbanization mean the far-ranging pachyderms are increasingly restricted to protected areas like game reserves. The risk? Contained populations could become genetically isolated over time, making elephants more vulnerable to disease and environmental change.

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Fur is a defining characteristic of mammals, coming in a wide variety of colors and patterns -- thanks to a world-first study, we now know which genes make a marsupial's coat black or grey.

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A new paper describes a ground-breaking experiment that united 25 independent taxonomists from 10 countries. The initiative boasts the discovery of 11 new marine species from all over the globe, occurring at depths from 5.2 to 7081 meters. It also represents a significant step forward in accelerating the pace at which new marine species are described and published.

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A study of horses -- which share many important similarities with humans in their chromosomes and pregnancies -- revealed that 42% of miscarriages and spontaneous abortions in the first two months of pregnancy were due to complications from an extra set of chromosomes, a condition called triploidy.

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Researchers reveal more about the tit-for-tat evolutionary changes occurring in both potato plants and the pathogen that caused the 1840s Irish potato famine.