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Categories: Biology: Genetics, Environmental: Biodiversity

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Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Molecular
Published

Nutrients direct intestinal stem cell function and affect aging      (via sciencedaily.com)     Original source 

The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.

Biology: Biochemistry Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology
Published

Researchers uncover genetic factors for severe Lassa fever      (via sciencedaily.com)     Original source 

Researchers report the results of the first ever genome-wide association study (GWAS) of a biosafety level 4 (BSL-4) virus. The team found two key human genetic factors that could help explain why some people develop severe Lassa fever, and a set of LARGE1 variants linked to a reduced chance of getting Lassa fever. The work could lay the foundation for better treatments for Lassa fever and other similar diseases. The scientists are already working on a similar genetics study of Ebola susceptibility.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Molecular
Published

New research uncovers biological drivers of heart disease risk      (via sciencedaily.com)     Original source 

Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

New approach to tackling bacterial infections identified      (via sciencedaily.com)     Original source 

Researchers have identified a new approach to controlling bacterial infections. The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system (CBASS), is a natural mechanism used by certain bacteria to protect themselves from viral attacks. Bacteria self-destruct as a means to prevent the spread of virus to other bacterial cells in the population.

Biology: Biochemistry Biology: Biotechnology Biology: Botany Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Molecular
Published

Researchers discover key to molecular mystery of how plants respond to changing conditions      (via sciencedaily.com)     Original source 

A team of researchers recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change -- either internally or in the external environment -- to thrive in good times or survive the bad times? The research, focused on plants, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Molecular
Published

Extra fingers and hearts: Pinpointing changes to our genetic instructions that disrupt development      (via sciencedaily.com)     Original source 

Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Computer Science: General
Published

Computer-engineered DNA to study cell identities      (via sciencedaily.com)     Original source 

A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.

Biology: Biochemistry Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology Biology: Zoology
Published

Smells like evolution: Fruit flies reveal surprises in chemical sensing      (via sciencedaily.com)     Original source 

New study reveals how gene expression shapes the diverse smelling and tasting abilities of different fly species. Most genes are surprisingly stable, but thousands have evolved to create unique olfactory landscapes. Sex differences in sensing are widespread and involve specific cell types in key tissues. The study provides insights into the evolution of sensory systems in general, with potential implications for understanding human olfaction.

Biology: Biochemistry Biology: Botany Biology: Cell Biology Biology: General Biology: Genetics Biology: Marine Biology: Microbiology Biology: Molecular Ecology: Sea Life Geoscience: Earth Science Geoscience: Geochemistry Geoscience: Geography Geoscience: Oceanography
Published

Vitamin B12 adaptability in Antarctic algae has implications for climate change, life in the Southern Ocean      (via sciencedaily.com)     Original source 

The algae P. antarctica has two forms of the enzyme that makes the amino acid methionine, one needing B12, and one that is slower, but doesn't need it. This means it has the ability to adapt and survive with low B12 availability. The presence of the MetE gene in P. antarctica gives the algae the ability to adapt to lower vitamin B12 availability, giving it a potential advantage to bloom in the early austral spring when bacterial production is low. P. antarctica takes in the CO2 and releases oxygen through photosynthesis. Understanding its ability to grow in environments with low vitamin B12 availability can help climate modelers make more accurate predictions.

Biology: Biochemistry Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Scientists see an ultra-fast movement on surface of HIV virus      (via sciencedaily.com)     Original source 

Seeing a glycoprotein on the envelope of the HIV virus snap open and shut in mere millionths of a second is giving investigators a new handle on the surface of the virus that could lead to broadly neutralizing antibodies for an AIDS vaccine. Being able to attach an antibody specifically to this little structure that would prevent it from popping open would be key.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Mechanism discovered that protects tissue after faulty gene expression      (via sciencedaily.com)     Original source 

A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Disrupted cellular function behind type 2 diabetes in obesity      (via sciencedaily.com)     Original source 

Disrupted function of 'cleaning cells' in the body may help to explain why some people with obesity develop type 2 diabetes, while others do not. A study describes this newly discovered mechanism.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Molecular
Published

A clutch stretch goes a long way      (via sciencedaily.com)     Original source 

New results reveal a new mode of force transmission in which dynamic molecular stretching bridges the extracellular matrix and flowing F-actin moving at different speeds. This discovery underscores the necessity of molecular elasticity and random coupling for sufficiently transmitting force. The findings also call for revising the role of molecular unfolding.

Biology: Biochemistry Biology: Botany Biology: Cell Biology Biology: Evolutionary Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular Ecology: Endangered Species
Published

Plant receptors that control immunity and development share a common origin      (via sciencedaily.com)     Original source 

Researchers have traced the origin and evolutionary trajectory of plant immune receptors. Their discovery will make it easier to identify immune receptor genes from genomic information and could help in the development of pathogen-resistant crops.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Gut bacteria can process dietary fiber into an anti-allergy weapon      (via sciencedaily.com)     Original source 

Short-chain fatty acids (SCFAs), which are produced by gut bacteria from dietary fiber, regulate our immune system, but the mechanism of their action remains unknown. In a recent study, researchers investigated how SCFAs interact with mast cells, a type of white blood cell that plays a central role in allergic reactions. Their findings and insights could lead to innovative and effective anti-allergy medications, supplements, and diets, paving the way for healthier lives.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: Developmental Biology: General Biology: Genetics Biology: Microbiology
Published

LSH genes associated with defining the shapes of stems, flowers and leaves required for N-fixing root nodules      (via sciencedaily.com)     Original source 

The developmental regulators that confer the identity of N-fixing root nodules belong to a transcription factor family (LSH) more commonly associated with defining the shapes of stems, flowers and leaves.

Biology: Biochemistry Biology: Biotechnology Biology: Cell Biology Biology: General Biology: Genetics Biology: Microbiology Biology: Molecular
Published

Shining a new light on the tug-of-war between virus and host      (via sciencedaily.com)     Original source 

The interplay between ribonucleic acid (RNA) and proteins is not only important for maintaining cellular homeostasis but is also at the center of the tug-of-war between virus and host. Until now, there has been no method to globally map direct interactions of individual RNA regions in an unbiased fashion without the need for genetic modification of the target RNA or cell. Researchers have now developed a breakthrough tool that overcomes this limitation.