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Categories: Biology: Genetics, Environmental: Biodiversity

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Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.

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The cell organelles known as 'peroxisomes' dispose toxic substances and fats in the human body, among other things, and, in doing so, they prevent serious illnesses. The 'Pex' group of proteins (peroxisomes biogenesis factors) keep these 'detox units' functioning properly -- and now researchers have shown, at the atomic level, how these highly complex processes proceed.

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Nitrogen is an essential nutrient for plant growth, but the overuse of synthetic nitrogen fertilizers in agriculture is not sustainable. A team of bacteriologists and plant scientists discuss the possibility of using genetic engineering to facilitate mutualistic relationships between plants and nitrogen-fixing microbes called 'diazotrophs.' These engineered associations would help crops acquire nitrogen from the air by mimicking the mutualisms between legumes and nitrogen-fixing bacteria.

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Scientists have discovered a simple and reliable test for signs of past or present life on other planets -- 'the holy grail of astrobiology.' Researchers report that, with 90% accuracy, their artificial intelligence-based method distinguished modern and ancient biological samples from those of abiotic origin.

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Ocean acidification will likely almost triple by the end of the century -- a drastic environmental change that could impact important marine species like fleshy seaweeds, algae that grow vertically and promote biodiversity in more than a third of the world's coastline. To get a better idea of how seaweeds might fare in a rapidly acidifying ocean, a team of marine scientists subjected a common fleshy seaweed species to the acidification levels expected by the end of the century. They report that increased acidification impacted the seaweed's chemical balance, made both its structure and its tissues weaker, and reduced its overall chances of survival.

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Researchers have made a significant finding in determining the genetic background of dilated cardiomyopathy in Dobermanns. This research helps us understand the genetic risk factors related to fatal diseases of the heart muscle and the mechanisms underlying the disease, and offers new tools for their prevention.

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Researchers have identified the threat greenwashing poses to a 'nature positive' world, one where environmental decline halts and biodiversity outcomes improve.

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Balanophora shed one third of its genes as it evolved into a streamlined parasitic plant -- an extreme degree of genome shrinkage even among parasites. Along the way this subtropical plant developed the ability to induce the host plant to grow into the parasite's own flesh -- forming chimeric organs that mix host and parasite tissues.

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Researchers have developed the first method to uncover the tasks that microRNAs perform in single cells. This is a huge improvement over existing state-of-the-art methods that require millions of cells and will for the first time allow researchers to study microRNAs in complex tissues such as brains.

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To make a gene-editing tool more precise and easier to control, engineers split it into two pieces that only come back together when a third molecule is added.

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Living things from plants to humans must constantly adjust the chemical soup of proteins -- the workhorse molecules of life -- inside their cells to adapt to stress or changing conditions. Now, researchers have identified a previously unknown molecular mechanism that helps explain how they do it. A team now reveals hairpin-like structures of mRNA that, by zipping and unzipping, help cells change the mix of proteins they produce when under stress.

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Scientists have mapped the reproductive strategies and life cycle of an endangered coral species, the purple cauliflower soft coral Dendronephthya australis. Lab-grown larvae have been successfully introduced back into the wild.

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Sewage pollution, whether treated or untreated, was found to be the primary driver of increased nutrients, algae, and sewage fungus in rivers. Sewage discharge also radically altered plant, animal, and microbe communities, increasing the abundance of harmful species. Run-off from agriculture was also found to lower water quality and be particularly harmful for sensitive insect groups.

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New research examines the 'revolution' in the study of deforestation brought about by satellites, and analyzing which kinds of policies might limit climate-altering deforestation.

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Researchers have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.

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Biologists have discovered why an enzyme is important for the survival of fruit flies, even though it can shorten their lives under certain conditions.

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X-rays of an ancient jawless fish shows earliest-known example of internal cartilage skull, unlike that of any other known vertebrate.

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A new study finds that most Rafflesia species, which produce the world's largest flowers, face extinction. Lack of protection at local, national, and international levels means that remaining populations are under critical threat.

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Using engineered microbes as microscopic factories has given the world steady sources of life-saving drugs, revolutionized the food industry, and allowed us to make sustainable versions of valuable chemicals previously made from petroleum. But behind each biomanufactured product on the market today is the investment of years of work and many millions of dollars in research and development funding. Scientists want to help the burgeoning industry reach new heights by accelerating and streamlining the process of engineering microbes to produce important compounds with commercial-ready efficiency.

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An international group of researchers have discovered a previously unknown species of large foraminifer, shedding new light on the ecological evolution and biodiversity of coral reefs in the Ryukyu Islands.