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Categories: Biology: Genetics, Geoscience: Landslides

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This is a significant development that brings hope to the one billion individuals with obesity worldwide. Researchers have discovered new insights into the regulation of fat metabolism. The focus of their study lies within the star-shaped non-neuronal cells in the brain, known as 'astrocytes'. Furthermore, the group announced successful animal experiments using the newly developed drug 'KDS2010', which allowed the mice to lose weigh without dietary restrictions.

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Researchers generated large scale gene expression data to investigate the molecular networks that operate in one of the closest algal relatives of land plants, a humble single-celled alga called Mesotaenium endlicherianum.

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A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a new study. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery.

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Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).

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Selective targeting of cancerous cells poses major clinical challenges during cancer therapy. However, this limitation can be overcome by using bioengineered bacteria with highly optimized chemical modifications. A recent study demonstrates the use of chemically modified purple photosynthetic bacteria for the successful detection and elimination of colon cancer cells in a mouse model. The study also sheds light on the underlying mechanism of action.

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High-quality sequencing of nearly the entire kakapo population is helping New Zealand to manage the health of this critically endangered species.

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Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.

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Terrestrial carbon sinks can mitigate the greenhouse effect. Researchers pooled various data sources and found that European carbon storage takes place mainly in surface biomass in East Europe. However, changes of land use in particular have caused this carbon sink to decline.

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As climate change progresses, rising temperatures may impact nitrogen runoff from land to lakes and streams more than projected increases in total and extreme precipitation for most of the continental United States, according to new research from a team of climate scientists.

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Researchers find large methane emissions: 'Do not flood low-lying areas with freshwater'. Their studies find that freshwater lakes emit much more methane than saltwater lagoons, bogs and wet meadows.

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Scientists once assumed that flooding and mudslides after wildfires were linked to the waxy coating that builds up on charred soil, preventing water absorption. Researchers found that water flow came from absorbed water in both burnt and unburnt areas, suggesting that water was, in fact, being absorbed into burnt ground. The discovery provides valuable insights into where and when potential flooding and mudslides may occur and how landscapes recover after a wildfire.

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A groundbreaking study reveals the critical yet severely understudied factor of salinity changes in ocean and coastlines caused by climate change.

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Many factors influence where a landslide will occur, including the shape of the terrain, its slope and drainage areas, the material properties of soil and bedrock, and environmental conditions like climate, rainfall, hydrology and ground motion resulting from earthquakes. Geologists have developed a new technique that uses artificial intelligence to better predict where and why landslides may occur could bolster efforts to protect lives and property in some of the world's most disaster-prone areas. The new method improves the accuracy and interpretability of AI-based machine-learning techniques, requires far less computing power and is more broadly applicable than traditional predictive models.

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In its simplest form, popcorn is pretty uncomplicated. Most supermarket varieties offer the choice of two kernel colors, yellow or white, and two kernel shapes, pointed or pearl. When popped, the flake typically expands into one of two shapes: mushroom or butterfly. But there's more to popcorn than meets the eye. New research reveals a wealth of untapped diversity lurking in popcorn's genetic code.

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A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies. Called the viral load, this is what is measured to allow clinicians to understand how patients are responding to anti-viral medications and monitor potential progression. The time-consuming viral load testing needs to be repeated several times as a patient undergoes treatment. Now, a research team has developed a time and cost-efficient digital assay that can directly measure the presence of HIV in single drop of blood.