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Categories: Biology: Genetics, Space: Exploration
Published Newfound mechanism suggests drug combination could starve pancreatic cancer
(via sciencedaily.com) Original source A study found that a new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for fuel.
Published Epigenetic regulator MOF drives mitochondrial metabolism
(via sciencedaily.com) Original source Researchers have unveiled a new mechanism for regulating mitochondrial function. The findings reveal the critical role played by the enzymatic activity of the lysine acetyltransferase MOF in maintaining mitochondrial integrity and function through acetylation of mitochondrial electron transport chain component COX17. Cells lacking MOF-mediated COX17 acetylation exhibit dramatic mitochondrial defects and impaired ability to produce energy. Underscoring the clinical relevance of these findings, the team also showed that cells from human patients with a developmental disorder caused by mutations in MOF also exhibited respiratory defects that could be ameliorated by interventions such as acetylation-mimetic COX17 or mitochondrially targeted MOF.
Published How male mosquitoes compensate for having only one X chromosome
(via sciencedaily.com) Researchers have discovered the master regulator responsible for balancing the expression of X chromosome genes between males and females in the malaria mosquito. This discovery helps scientists better understand the evolution of the epigenetic mechanisms responsible for equalizing gene expression between the sexes. The findings may contribute to the development of new ways to prevent the spread of malaria.
Published Natural GM crops: Grasses take evolutionary shortcut by borrowing genes from their neighbors
(via sciencedaily.com) Original source Grass may transfer genes from their neighbors in the same way genetically modified crops are made, a new study has revealed.
Published New discovery may 'unlock' the future of infectious disease and cancer treatment
(via sciencedaily.com) Original source Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.
Published The end of genes: Routine test reveals unique divergence in genetic code
(via sciencedaily.com) Original source Scientists testing a new method of sequencing single cells have unexpectedly changed our understanding of the rules of genetics. The genome of a protist has revealed a seemingly unique divergence in the DNA code signalling the end of a gene, suggesting the need for further research to better understand this group of diverse organisms.
Published New open-source method to improve decoding of single-cell data
(via sciencedaily.com) Original source Researchers have developed a new open-source computational method, dubbed Spectra, which improves the analysis of single-cell transcriptomic data. By guiding data analysis in a unique way, Spectra can offer new insights into the complex interplay between cells — like the interactions between cancer cells and immune cells, which are critical to improving immunotherapy treatments.
Published Ruffed grouse population more resilient than expected, genetic study finds
(via sciencedaily.com) Original source Despite decades of decline, a genetic analysis of ruffed grouse reveals that Pennsylvania's state bird harbors more genetic diversity and connectivity than expected. The findings suggest that the iconic game bird could be maintained in persistent numbers if appropriate protections are implemented.
Published Being a vegetarian may be partly in your genes
(via sciencedaily.com) Original source A person's genetic makeup plays a role in determining whether they can stick to a strict vegetarian diet, a new study has found. The findings open the door to further studies that could have important implications regarding dietary recommendations and the production of meat substitutes.
Published Proteins roll the dice to determine bee sex
(via sciencedaily.com) Original source To date it has been unclear exactly how the sex of a bee is determined. A research team comprising biologists and chemists has now identified a key gene and the molecular mechanism linked with it. They describe how this process is similar to a game involving two dice.
Published Avatars to help tailor glioblastoma therapies
(via sciencedaily.com) Original source Scientists have created a new zebrafish xenograft platform to screen for novel treatments for an aggressive brain tumor called glioblastoma, according to a new study.
Published Honeybees are more selective in their choices for nutrition than previously thought
(via sciencedaily.com) Original source An international research group examined which plants honeybees favor when collecting nectar and pollen. The choices honeybees make have an impact on their health and also on humans, as honeybees pollinate important crop plants.
Published Ancient technology turns plant-based cheese into 'something we want to eat'
(via sciencedaily.com) Original source To produce plant-based cheeses that feel and taste like dairy cheese, scientists have their sights set on fermentation. In a new research result, scientists demonstrate the potential of fermentation for producing climate-friendly cheeses that people want to eat.
Published New pipeline makes valuable organic acid from plants -- saving money and emissions
(via sciencedaily.com) Original source In a breakthrough for environmentally friendly chemical production, researchers have developed an economical way to make succinic acid, an important industrial chemical, from sugarcane. The team has created a cost-effective, end-to-end pipeline for this valuable organic acid by engineering a tough, acid-tolerant yeast as the fermenting agent, avoiding costly steps in downstream processing. Succinic acid is a widely used additive for food and beverages and has diverse applications in agricultural and pharmaceutical products. This same pipeline can be used to produce other industrially important organic acids from crops rather than petroleum-based processes, significantly reducing greenhouse gas emissions.
Published Large mound structures on Kuiper belt object Arrokoth may have common origin
(via sciencedaily.com) Original source A new study posits that the large, approximately 5-kilometer-long mounds that dominate the appearance of the larger lobe of the pristine Kuiper Belt object Arrokoth are similar enough to suggest a common origin. The study suggests that these “building blocks” could guide further work on planetesimal formational models.
Published Study quantifies satellite brightness, challenges ground-based astronomy
(via sciencedaily.com) Original source The ability to have access to the Internet or use a mobile phone anywhere in the world is taken more and more for granted, but the brightness of Internet and telecommunications satellites that enable global communications networks could pose problems for ground-based astronomy. Scientists confirm that recently deployed satellites are as bright as stars seen by the unaided eye.
Published Bursts of star formation explain mysterious brightness at cosmic dawn
(via sciencedaily.com) Original source In the James Webb Space Telescope’s (JWST) first images of the universe’s earliest galaxies, the young galaxies appear too bright, too massive and too mature to have formed so soon after the Big Bang. Using new simulations, a team of astrophysicists now has discovered that these galaxies likely are not so massive after all. Although a galaxy’s brightness is typically determined by its mass, the new findings suggest that less massive galaxies can glow just as brightly from irregular, brilliant bursts of star formation.
Published When cells go boom: Study reveals inflammation-causing gene carried by millions
(via sciencedaily.com) Original source Researchers have found that a genetic change that increases the risk of inflammation, through a process described as ‘explosive’ cell death, is carried by up to 3% of the global population.
Published Scientists identify evolutionary gateway helping pneumonia bacteria become resistant to antibiotics
(via sciencedaily.com) Original source An evolutionary gateway which helps pneumonia cells become resistant to antibiotics has been discovered.
Published How new plant cell walls change their mechanical properties after cell division
(via sciencedaily.com) Original source Scientists reveal new plant cell walls can have significantly different mechanical properties compared to surrounding parental cell walls, enabling cells to change their local shape and influence the growth of plant organs.