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Categories: Biology: Genetics, Space: Exploration

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Researchers are further improving CRISPR's versatility to engineer new grasses and yeasts for biochemical production.

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Researchers have created a new version of a microbe to compete economically with E. coli -- a bacteria commonly used as a research tool due to its ability to synthesize proteins -- to conduct low-cost and scalable synthetic biological experiments.

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A new clinical trial suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them. The findings highlight how close -- yet still far -- researchers have come to developing a cure for HIV-1.

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The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.

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Astronomers have uncovered evidence of how the enigmatic gap in the size distribution of exoplanets at around two Earth radii emerges. Their computer simulations demonstrate that the migration of icy, so-called sub-Neptunes into the inner regions of their planetary systems could account for this phenomenon. As they draw closer to the central star, evaporating water ice forms an atmosphere that makes the planets appear larger than in their frozen state. Simultaneously, smaller rocky planets gradually lose a portion of their original gaseous envelope, causing their measured radius to shrink over time.

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Researchers report the results of the first ever genome-wide association study (GWAS) of a biosafety level 4 (BSL-4) virus. The team found two key human genetic factors that could help explain why some people develop severe Lassa fever, and a set of LARGE1 variants linked to a reduced chance of getting Lassa fever. The work could lay the foundation for better treatments for Lassa fever and other similar diseases. The scientists are already working on a similar genetics study of Ebola susceptibility.

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Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.

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Saturn's moon Mimas harbors a global ocean beneath its icy shell, discovered through analysis of its orbit by Cassini spacecraft data. This ocean formed just 5-15 million years ago, making Mimas a prime candidate for studying early ocean formation and potential for life. This discovery suggests life-essential conditions might exist on seemingly inactive moons, expanding our search for life beyond Earth.

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Two astrophysicists have finally solved a 20-year-old astrophysical puzzle concerning the lower-than-expected amounts of the element sulphur found in Planetary Nebulae (PNe) in comparison to expectations and measurements of other elements and other types of astrophysical objects. The expected levels of sulphur have long appeared to be 'missing in action'. However, they have now finally reported for duty after hiding in plain sight, as a result of leveraging highly accurate and reliable data.

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Researchers have identified a new approach to controlling bacterial infections. The team found a way to turn on a vital bacterial defense mechanism to fight and manage bacterial infections. The defense system, called cyclic oligonucleotide-based antiphage signaling system (CBASS), is a natural mechanism used by certain bacteria to protect themselves from viral attacks. Bacteria self-destruct as a means to prevent the spread of virus to other bacterial cells in the population.

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A team of researchers recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change -- either internally or in the external environment -- to thrive in good times or survive the bad times? The research, focused on plants, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.

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Employing massive data sets collected through NASA's James Webb Space Telescope, astronomers are unearthing clues to conditions existing in the early universe. The team has catalogued the ages of stars in the Wolf--Lundmark--Melotte (WLM) galaxy, constructing the most detailed picture of it yet, according to the researchers. WLM, a neighbor of the Milky Way, is an active center of star formation that includes ancient stars formed 13 billion years ago.

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Researchers have developed a new biocontainment method for limiting the escape of genetically engineered organisms used in industrial processes.

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A carbon monoxide (CO)-runaway gap identified in the atmospheres of Earth-like planets can help expand the search for habitable planets. This gap, identified through atmospheric modeling, is an indicator of a CO-rich atmosphere on Earth-like planets orbiting Sun-like stars. CO is an important compound for the formation of prebiotic organic compounds, which are building blocks for more complex molecules for the formation of life.

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China's Chang'e-5, the first lunar sample return mission since the Soviet Union's Luna 24 in 1976, delivered 1.73 kilograms of regolith from the Oceanus Procellarum, a plane named for its vast size. The sample landed with CE-5 in late 2020 and included a new mineral, Changesite-(Y), as well as a perplexing combination of silica minerals. Researchers now compare CE-5's material composition to other lunar and Martian regolith samples and examine potential causes and origins for the lunar sample's unique makeup.

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Black holes not only existed at the dawn of time, they birthed new stars and supercharged galaxy formation, a new analysis of James Webb Space Telescope data suggests.

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Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.

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A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.

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New study reveals how gene expression shapes the diverse smelling and tasting abilities of different fly species. Most genes are surprisingly stable, but thousands have evolved to create unique olfactory landscapes. Sex differences in sensing are widespread and involve specific cell types in key tissues. The study provides insights into the evolution of sensory systems in general, with potential implications for understanding human olfaction.

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The algae P. antarctica has two forms of the enzyme that makes the amino acid methionine, one needing B12, and one that is slower, but doesn't need it. This means it has the ability to adapt and survive with low B12 availability. The presence of the MetE gene in P. antarctica gives the algae the ability to adapt to lower vitamin B12 availability, giving it a potential advantage to bloom in the early austral spring when bacterial production is low. P. antarctica takes in the CO2 and releases oxygen through photosynthesis. Understanding its ability to grow in environments with low vitamin B12 availability can help climate modelers make more accurate predictions.