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Categories: Biology: Genetics, Geoscience: Geology

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A research group has developed a new method that further improves the existing CRISPR/Cas technologies: it allows a more precise and seamless introduction of tags into proteins at the gene level. This technology could significantly improve research on proteins in living organisms and opens up new possibilities for medical research.

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Geneticists uncover new insights into how sex chromosome systems work in the platypus and the chicken -- which will lead to better understandings of our own sex chromosome evolution and gene regulation.

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Researchers have modified certain bacteria with UV light so that they produce more cellulose. The basis for this is a new approach with which the researchers generate thousands of bacterial variants and select those that have developed into the most productive.

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MicroRNAs can make plants more capable of withstanding drought, salinity, pathogens and more. However, in a recent study scientists showed just how much we didn't know about the intricate processes plants use to produce them.

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Sapphires are among the most precious gems, yet they consist solely of chemically 'contaminated' aluminum oxide, or corundum. It is widely assumed that these crystals with their characteristically blue color come from deep crustal rocks and accidentally ended up on the Earth's surface as magma ascended. Geoscientists have now been able to show that the sapphire grains found in the Eifel (Germany) formed in association with volcanism.

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A canine gallbladder disease that involves the accumulation of abnormal mucus similar to that seen in human cystic fibrosis (CF) patients is caused by improper expression of the gene associated with CF in humans. The finding could have implications for human CF patients as well as for animal models of CF.

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Cotton is woven into the very fabric of our lives, from soft T-shirts to comfortable jeans and cozy bedsheets. It's the world's leading renewable textile fiber and the backbone of a global industry worth billions. As climate change intensifies, cotton farmers face increasing challenges from drought and heat. However, new research offers hope for developing more resilient varieties that can maintain high yields even under water-stressed conditions.

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A research team has published a groundbreaking study on malignant catarrhal fever (MCF). This disease is caused by the alcelaphine gammaherpesvirus 1 (AlHV-1), which infects its natural host, the wildebeest. This study sheds light on the mechanisms by which this virus, which is asymptomatic and latent in the wildebeest, causes an oligoclonal expansion of CD8+ T lymphocytes in cattle, leading to the development of MCF.

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A study opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumor necrosis factor- (TNF- ) and its receptors TNFR, molecules of key interest in biomedicine due to their involvement in multiple diseases such as obesity related to type 2 diabetes mellitus, inflammatory bowel disease and several types of cancer.

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Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.

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An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

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Researchers are working to create the first strain of mice that's genetically susceptible to late-onset Alzheimer's, with potentially transformative implications for dementia research.

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New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what is known about the signalling mechanisms involving PTPRK as a phosphatase and its role in colorectal health but also shed new light on the extent of its function via non-catalytic signalling mechanisms.

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A new analysis of rocks thought to be at least 2.5 billion years old helps clarify the chemical history of Earth's mantle -- the geologic layer beneath the planet's crust. The findings hone scientists' understanding of Earth's earliest geologic processes, and they provide new evidence in a decades-long scientific debate about the geologic history of Earth. Specifically, the results provide evidence that the oxidation state of the vast majority of Earth's mantle has remained stable through geologic time and has not undergone major transitions, contrary to what has been suggested previously by other researchers.

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Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on conditions, small membrane regions can stabilize various lipids to trigger specific cellular responses. These discoveries confirm the existence of well-organized lipid domains and begin to reveal the role they play in cell survival.

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New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance.

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A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.

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Fluids circulating underground change rocks over the course of time. These processes must be taken into account if they are to be used as a climate archive. Researchers have used 380-million-year-old limestones from Hagen-Hohenlimburg to show in detail which climate information is still preserved in the rock.

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Scientists have succeeded in pinpointing the neurons within a female fruit fly's brain that respond to signals from the male during mating.

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Scientists have identified the genetic mutation that causes progressive retinal atrophy in English Shepherd Dogs, which results in incurable blindness, and developed a genetic test to help eliminate the disease from future generations of the breed.