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Categories: Biology: Genetics, Paleontology: General

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A research team has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer's disease brain neurons.

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Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.

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White blood cells known as neutrophils feature a nucleus that is structured strikingly different than most nuclei. These unique shapes permit neutrophils to travel all over the body to combat invading pathogens. Scientists have now deciphered the shapeshifting puzzle of the neutrophil nucleus.

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Athletes often suffer injuries to ligaments in their knees, particularly to the anterior cruciate ligament or ACL. While surgery to replace these torn ligaments is becoming increasingly common around the world it often needs to be repeated. That's because it has proved challenging to anchor fibrous, soft and wet ligament grafting material into hard bone. Now, researchers have new information from the eggshell membrane in chicken eggs that could help change this picture thanks to the potential it offers for improvements in tissue engineering and biomaterial grafts. Their findings also have the potential to reduce losses for commercial egg and poultry producers.

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From lab-grown chicken to cricket-derived protein, these innovative alternatives offer hope for a planet struggling with the environmental and ethical impacts of industrial agriculture. Now, scientists add a new recipe to the list -- cultured beef rice -- by growing animal muscle and fat cells inside rice grains. The method results in a nutritious and flavorful hybrid food that, once commercialized, could offer a more affordable protein alternative with a smaller carbon footprint.

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Scientists have determined how the well-known plant hormone ethylene is crucial in controlling the angle at which roots grow. The findings can be used to engineer plants and crops that withstand the environmental stresses of climate change and drought, and perhaps to create plants that remove carbon dioxide from the atmosphere and store it deep underground to help mitigate climate change.

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Researchers are further improving CRISPR's versatility to engineer new grasses and yeasts for biochemical production.

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Researchers have created a new version of a microbe to compete economically with E. coli -- a bacteria commonly used as a research tool due to its ability to synthesize proteins -- to conduct low-cost and scalable synthetic biological experiments.

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A new clinical trial suggests that a combination of the drug vorinostat and immunotherapy can coax HIV-infected cells out of latency and attack them. The findings highlight how close -- yet still far -- researchers have come to developing a cure for HIV-1.

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The bead found at the La Prele Mammoth site in Wyoming's Converse County is about 12,940 years old and made of bone from a hare.

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The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.

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This study reports widespread mineral carbonation of mantle rocks in an oceanic transform fueled by magmatic degassing of CO2. The findings describe a previously unknown part of the geological carbon cycle in transform faults that represent one of the three principal plate boundaries on Earth. The confluence of tectonically exhumed mantle rocks and CO2-rich alkaline basalt formed through limited extents of melting characteristic of the St. Paul's transform faults may be a pervasive feature at oceanic transform faults in general. Because transform faults have not been accounted for in previous estimates of global geological CO2 fluxes, the mass transfer of magmatic CO2 to the altered oceanic mantle and seawater may be larger than previously thought.

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Scientists examined hundreds of birds in museum collections and discovered a suite of feather characteristics that all flying birds have in common. These 'rules' provide clues as to how the dinosaur ancestors of modern birds first evolved the ability to fly, and which dinosaurs were capable of flight.

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Snail shells are often colorful and strikingly patterned. This is due to pigments that are produced in special cells of the snail and stored in the shell in varying concentrations. Fossil shells, on the other hand, are usually pale and inconspicuous because the pigments are very sensitive and have already decomposed. Residues of ancient color patterns are therefore very rare. This makes a new discovery all the more astonishing: researchers found pigments in twelve-million-year-old fossilized snail shells.

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Nearly 400 exceptionally well-preserved fossils dating back 470 million years have been discovered in the south of France by two amateur paleontologists. The discovery provides unprecedented information on the polar ecosystems of the Ordovician period.

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Researchers report the results of the first ever genome-wide association study (GWAS) of a biosafety level 4 (BSL-4) virus. The team found two key human genetic factors that could help explain why some people develop severe Lassa fever, and a set of LARGE1 variants linked to a reduced chance of getting Lassa fever. The work could lay the foundation for better treatments for Lassa fever and other similar diseases. The scientists are already working on a similar genetics study of Ebola susceptibility.

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The Greenland ice sheet lies thousands of miles from North America yet holds clues to the distant continent's environmental history. Nearly two miles thick in places, the ice sheet grows as snow drifts from the sky and builds up over time. But snow isn't the only thing carried in by air currents that swirl around the atmosphere, with microscopic pollen grains and pieces of ash mixing with snowfall and preserving records of the past in the ice. A new study examined these pollen grains and identified how eastern Canada's forests grew, retreated, and changed through time.

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Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57-million-year-long global 'Sturtian' ice age.

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Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.

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Dinosaurs' range of locomotion made them incredibly adaptable, researchers have found.