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Categories: Biology: Genetics, Paleontology: Early Mammals and Birds

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Researchers generated large scale gene expression data to investigate the molecular networks that operate in one of the closest algal relatives of land plants, a humble single-celled alga called Mesotaenium endlicherianum.

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A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a new study. The discovery is a significant advance in cell biology, likely solves a long-standing mystery about an unusual feature of some ion channels and has implications for the development of drugs targeting these proteins and for drug delivery.

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Researchers applied a new technology to generate the full inventory of mutations in the bacterial species Escherichia coli where the antibiotic rifampicin attaches to and disables an essential bacterial enzyme known as RNA polymerase (RNAP).

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Selective targeting of cancerous cells poses major clinical challenges during cancer therapy. However, this limitation can be overcome by using bioengineered bacteria with highly optimized chemical modifications. A recent study demonstrates the use of chemically modified purple photosynthetic bacteria for the successful detection and elimination of colon cancer cells in a mouse model. The study also sheds light on the underlying mechanism of action.

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High-quality sequencing of nearly the entire kakapo population is helping New Zealand to manage the health of this critically endangered species.

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Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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In a groundbreaking endeavor, researchers have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan. The research opens exciting possibilities for unlocking the secrets of aging and extending human lifespan.

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Radiocarbon dating on bones in the La Brea Tar Pits lead archaeologists to warn that history may be repeating itself.

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Did the pterosaurs, flying reptiles from the days of the dinosaurs, practice parental care or not? New research shows that pterosaurs were indeed caring parents -- but only the larger species.

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Scientists have described an unusual fossil from around 125 million years ago in China that shows a dramatic moment in time when a carnivorous mammal attacked a larger plant-eating dinosaur. The two animals are locked in mortal combat, and it's among the first evidence to show actual predatory behavior by a mammal on a dinosaur. The fossil's presence challenges the view that dinosaurs had few threats from their mammal contemporaries during the Cretaceous, when dinosaurs were the dominant animals.

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Ice Age saber-tooth cats and dire wolves experienced a high incidence of bone disease in their joints, according to new research.

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A new study reveals the iconic extinct Megalodon, or 'megatooth shark', was a rather slow cruiser that used its warm-bloodedness to facilitate digestion and absorption of nutrients.

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Researchers have finally settled a decades-long dispute about the evolutionary origins of the pygmy right whale.

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Birds are the only group of dinosaurs that survived the asteroid-induced mass extinction 66 million years ago. But not all the birds alive at the time made it. Why the ancestors of modern birds lived while so many of their relatives died has been a mystery that paleontologists have been trying to solve for decades. Two new studies point to one possible factor: the differences between how modern birds and their ancient cousins molt their feathers.

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The lower jaws of lizards, birds, fish and even dinosaurs are comprised of multiple bones per side. Yet mammals diverged from all other vertebrates and settled on just one bone, repurposing the extra bones into a more elaborate inner ear, perhaps the better to hear. The single bone per side, fused in primates into one jawbone, makes the jaw more rigid. A paleontologist asks, Did the stiffer, rigid jaw make mammals more successful?

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In its simplest form, popcorn is pretty uncomplicated. Most supermarket varieties offer the choice of two kernel colors, yellow or white, and two kernel shapes, pointed or pearl. When popped, the flake typically expands into one of two shapes: mushroom or butterfly. But there's more to popcorn than meets the eye. New research reveals a wealth of untapped diversity lurking in popcorn's genetic code.