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Categories: Biology: Genetics, Chemistry: Biochemistry
Published The on-and-off affair in DNA
(via sciencedaily.com) Original source Researchers have discovered that in thale cresses histone H3 lysine-9 (H3K9) methylation, conventionally thought to be a mark of turning off gene transcription, can also turn on gene expression via the interactions of two other proteins and histone marks. The molecular mechanisms demonstrate that rather than functioning as a simple 'off switch,' H3K9 methylation is more like a 'dimmer switch' that fine-tunes DNA transcription. The discovery suggests there might be similar mechanisms in other organisms, too.
Published A new study highlights potential of ultrafast laser processing for next-gen devices
(via sciencedaily.com) Original source A new study uncovers the remarkable potential of ultrafast lasers that could provide innovative solutions in 2D materials processing for many technology developers such as high-speed photodetectors, flexible electronics, biohybrids, and next-generation solar cells.
Published Towards non-toxic antifouling agents: A novel method for total synthesis of scabrolide F
(via sciencedaily.com) Original source Norcembranolide diterpenes, isolated from the soft corals of the genus Sinularia, are important compounds for the development of new drugs, owing to their diverse biological activities. However, total synthesis methods for these compounds are scarce. Now, a team of researchers has achieved the total synthesis of scabrolide F, a norcembranolide diterpene. They also revealed its non-toxic antifouling properties. This novel method can lead to the development of new drugs and antifouling agents.
Published Revealing the dynamic choreography inside multilayer vesicles
(via sciencedaily.com) Original source Our cells and the machinery inside them are engaged in a constant dance. This dance involves some surprisingly complicated choreography within the lipid bilayers that comprise cell membranes and vesicles -- structures that transport waste or food within cells. In a recent paper, researchers shed some light on how these vesicles self-assemble, knowledge that could help scientists design bio-inspired vesicles for drug-delivery or inspire them to create life-like synthetic materials.
Published Light-weight microscope captures large-scale brain activity of mice on the move
(via sciencedaily.com) Original source With a new microscope that's as light as a penny, researchers can now observe broad swaths of the brain in action as mice move about and interact with their environments.
Published Zebrafish reveal how bioelectricity shapes muscle development
(via sciencedaily.com) Original source New research describes how nerve cells and muscle cells communicate through electrical signals during development -- a phenomenon known as bioelectricity. The communication, which takes place via specialized channels between cells, is vital for proper development and behavior. The study identifies specific genes that control the process, and pins down what happens when it goes wrong. The finding offers clues to the genetic origins of muscle disorders in humans.
Published Discovery of vast sex differences in cellular activity has major implications for disease treatment
(via sciencedaily.com) Original source The study reveals vast differences in gene activity within the mitochondria of males compared to females. This is the first study to test effects of all 37 genes in the mitochondrial genome -- genes that copepods and humans share. The study found that males demonstrate more activity across all protein-coding mitochondrial genes than females. Although the study looks at tiny marine organisms called copepods, the findings have weighty implications for human medicine.
Published Researchers discover new flat electronic bands, paving way for advanced quantum materials
(via sciencedaily.com) Original source Scientists predict the existence of flat electronic bands at the Fermi level, a finding that could enable new forms of quantum computing and electronic devices.
Published Wildfires increasingly threaten oil and gas drill sites, compounding potential health risks
(via sciencedaily.com) Original source More than 100,000 oil and gas wells across the western U.S. are in areas burned by wildfires in recent decades, a new study has found, and some 3 million people live next to wells that in the future could be in the path of fires worsened by climate change.
Published Robots face the future
(via sciencedaily.com) Original source Researchers have found a way to bind engineered skin tissue to the complex forms of humanoid robots. This brings with it potential benefits to robotic platforms such as increased mobility, self-healing abilities, embedded sensing capabilities and an increasingly lifelike appearance. Taking inspiration from human skin ligaments, the team included special perforations in a robot face, which helped a layer of skin take hold.
Published 3D-printed chip sensor detects foodborne pathogens for safer products
(via sciencedaily.com) Original source Researchers have developed a new method for detecting foodborne pathogens that is faster, cheaper, and more effective than existing methods. Their microfluidic chip uses light to detect multiple types of pathogens simultaneously and is created using 3D printing, making it easy to fabricate in large amounts and modify to target specific pathogens. The researchers hope their technique can improve screening processes and keep contaminated food out of the hands of consumers.
Published Researchers develop RNA-targeting technology for precisely manipulating parts of human genes
(via sciencedaily.com) Original source Researchers have harnessed a bacterial immune defense system, known as CRISPR, to efficiently and precisely control the process of RNA splicing. The technology opens the door to new applications, including systematically interrogating the functions of parts of genes and correcting splicing deficiencies that underlie numerous diseases and disorders.
Published Removal of excess chloride ions by plants when subjected to salt stress
(via sciencedaily.com) Original source Researchers have discovered a salt adaptation mechanism in plants that facilitates chloride removal from the roots and enhancing salinity tolerance. A research team has uncovered a novel mechanism of plant adaptation to salt stress involving the NaCl-induced translocation of a specific chloride channel protein, AtCLCf.
Published Researchers engineer AI path to prevent power outages
(via sciencedaily.com) Original source Researchers developed an artificial intelligence (AI) model that could help electrical grids prevent power outages by automatically rerouting electricity in milliseconds. The approach is an early example of 'self-healing grid' technology, which uses AI to detect and repair problems such as outages autonomously and without human intervention when issues occur, such as storm-damaged power lines.
Published How cells boost gene expression
(via sciencedaily.com) Original source The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.
Published Prying open the AI black box
(via sciencedaily.com) Original source Meet SQUID, a new computational tool. Compared with other genomic AI models, SQUID is more consistent, reduces background noise, and can yield better predictions regarding critical mutations. The new system aims to bring scientists closer to their findings' true medical implications.
Published Controlling electronics with light: The magnetite breakthrough
(via sciencedaily.com) Original source Researchers have discovered that by shining different wavelengths (colors) of light on a material called magnetite, they can change its state, e.g. making it more or less conducive to electricity. The discovery could lead to new ways of designing new materials for electronics such as memory storage, sensors, and other devices that rely on fast and efficient material responses.
Published Membrane protein analogues could accelerate drug discovery
(via sciencedaily.com) Original source Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these proteins from cell membranes.
Published Lab-grown muscles reveal mysteries of rare muscle diseases
(via sciencedaily.com) Original source Biomedical engineers have grown muscles in a lab to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle muscular dystrophies 2B (LGMD2B). The research revealed the biological mechanisms underlying the disease and showed that a combination of existing treatments could alleviate its symptoms.
Published How to make aging a 'fairer game' for all wormkind
(via sciencedaily.com) Original source Researchers have discovered a new fundamental mechanism governing the rules of ageing in worms. The researchers were able to manipulate the mechanism through genetic interventions which dramatically extend not just the lifespan of the worms, but also their health-span. In other words, trading weak, frail old age with vigorous golden years -- all without altering their diet, environment or other external factors.