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Categories: Biology: Genetics, Chemistry: Biochemistry

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Researchers have used a novel combination of short-read and long-read RNA sequencing to identify the different isoforms of genes expressed in the crustacean Daphnia magna. Males and females are genetically identical, but using this technique the team revealed genes that switch the predominant isoform in a male-female-dependent manner. This study may help further advance technologies in crustacean aquaculture.

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Researchers have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus.

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Introns are perhaps one of our genome's biggest mysteries. They are DNA sequences that interrupt the sensible protein-coding information in your genes, and need to be 'spliced out.'

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Researchers have taken a key step toward closing the silver nanoparticles knowledge gap with a study that indicates the particles' shape and surface chemistry play key roles in how they affect aquatic ecosystems.

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What if your earbuds could do everything your smartphone can, but better? A new class of synthetic materials could allow for smaller devices that use less power.

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Most people with early-stage glaucoma don't know they have it, even though early treatment is key to reducing vision loss. While detecting a subtle increase in eye pressure helps doctors to diagnose glaucoma, it's challenging to monitor continuously, especially with the variety of temperatures eyes experience. Now, researchers report a prototype 'smart' contact lens that measures eye pressure accurately, regardless of temperature.

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Researchers report a new method that reduces the amount of iridium needed to produce hydrogen from water by 95%, without altering the rate of hydrogen production. This breakthrough could revolutionize our ability to produce ecologically friendly hydrogen and help usher in a carbon-neutral hydrogen economy.

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In a study of a species of African butterfly, researchers have discovered a previously undescribed molecular mechanism of how the sex of an embryo is initially specified.

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Perovskites are among the most researched topics in materials science. Recently, a research team has solved an age-old challenge to synthesize all-organic two-dimensional perovskites, extending the field into the exciting realm of 2D materials. This breakthrough opens up a new field of 2D all-organic perovskites, which holds promise for both fundamental science and potential applications.

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Researchers have developed a robotic feeding system that uses computer vision, machine learning and multimodal sensing to safely feed people with severe mobility limitations, including those with spinal cord injuries, cerebral palsy and multiple sclerosis.

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Walking and running is notoriously difficult to recreate in robots. Now, a group of researchers has overcome some of these challenges by creating an innovative method that employs central pattern generators -- neural circuits located in the spinal cord that generate rhythmic patterns of muscle activity -- with deep reinforcement learning. The method not only imitates walking and running motions but also generates movements for frequencies where motion data is absent, enables smooth transition movements from walking to running, and allows for adapting to environments with unstable surfaces.

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A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation. This innovative approach will help to investigate the role of chromatin modifications in many biological processes, and to program desired gene activity responses, which may prove useful in disease settings.

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Chemists created an enzyme with boronic acid at its reactive center. This approach can produce more selective reactions with boron, and allows the use of directed evolution to improve its catalytic power.

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A tiny, flexible electronic device that wraps around the spinal cord could represent a new approach to the treatment of spinal injuries, which can cause profound disability and paralysis. A team of engineers, neuroscientists and surgeons developed the devices and used them to record the nerve signals going back and forth between the brain and the spinal cord. Unlike current approaches, the new devices can record 360-degree information, giving a complete picture of spinal cord activity.

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When old food packaging, discarded children's toys and other mismanaged plastic waste break down into microplastics, they become even harder to clean up from oceans and waterways. These tiny bits of plastic also attract bacteria, including those that cause disease. Researchers describe swarms of microscale robots (microrobots) that captured bits of plastic and bacteria from water. Afterward, the bots were decontaminated and reused.

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Tracking individual enzymes during the breakdown of cellulose for biofuel production has revealed how several roadblocks slow this process when using plant material that might otherwise go to waste. The research may lead to new ways to improve the breakdown process and make the non-edible parts of plants and other plant waste, such as forestry residue, a more competitive source of biofuels.

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Move over, graphene. There's a new, improved two-dimensional material in the lab. Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Now, researchers have made the material potentially more useful by imparting chirality -- or handedness -- on it, which could make for advanced sensors and implantable medical devices.

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Researchers used a breast cancer cell line panel and primary tumor explants from breast and cervical cancer patients to examine two different cellular contractility modes: one that generates collective tissue surface tension that keeps cell clusters compact and another, more directional, contractility that enables cells to pull themselves into the extracellular matrix. They found that more aggressive cells pull more strongly on the ECM than on themselves while noninvasive cells pull more strongly on themselves than on the ECM -- and that the different pulling behaviors are attributed to different structures of actin cytoskeleton inside the cells.

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Researchers have found that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell. The new information will help to understand the interaction between herpesvirus and host cells. Knowledge can be utilized in the development of viral treatments.

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The earliest stages of mammalian embryo development are like an orchestra performance, where everyone must play at the exact right moment and in perfect harmony. New research identifies one of the conductors making sense of the chaos.