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Categories: Biology: Genetics
Published Surprise finding in study of environmental bacteria could advance search for better antibiotics
(via sciencedaily.com) Original source Researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape. Because the integrity of a bacterial cell's 'envelope' or enclosure is key to its survival, the finding could advance the search for new and better antibiotics.
Published Revealing the mysteries within microbial genomes
(via sciencedaily.com) Original source A new technique will make it much easier for researchers to discover the traits or activities encoded by genes of unknown function in microbes, a key step toward understanding the roles and impact of individual species within the planet's diverse microbiomes.
Published How bread dough gave rise to civilization
(via sciencedaily.com) Original source A major international study has explained how bread wheat helped to transform the ancient world on its path to becoming the iconic crop that today helps sustain a global population of eight billion.
Published Beige fat cells with a 'Sisyphus mechanism'
(via sciencedaily.com) Original source A new class of fat cells makes people healthier. The cells consume energy and produce heat through seemingly pointless biochemical reactions.
Published A ketogenic diet could improve the response to pancreatic cancer therapy
(via sciencedaily.com) Original source Scientists have discovered a way to get rid of pancreatic cancer in mice by putting them on a high fat, or ketogenic, diet and giving them cancer therapy.
Published Decoding the world's largest animal genome
(via sciencedaily.com) Original source Scientists have sequenced the largest genome of all animals, the lungfish genome. Their data help to explain how the fish-ancestors of today's land vertebrates were able to conquer land.
Published Researchers call for genetically diverse models to drive innovation in drug discovery
(via sciencedaily.com) Original source Researchers unveiled an approach to drug discovery that could revolutionize how we understand and treat diseases. Their commentary explains the limitations of studies using traditional mouse models and proposes using genetically diverse mice and mouse and human cells to better predict human responses to drugs and diseases.
Published Exciting advance in stem cell therapy
(via sciencedaily.com) Original source A new technique for mechanically manipulating stem cells could lead to new stem cell treatments, which have yet to fulfill their therapeutic potential.
Published Surprising insight into cancer comes from unique plant species that find different solutions to evolutionary challenges
(via sciencedaily.com) Original source A study has shown that different plant species tackle the same evolutionary hurdle in different ways, and the findings may give insight into aggressive forms of cancer.
Published Rewriting the evolutionary history of critical components of the nervous system
(via sciencedaily.com) Original source A new study has rewritten the conventionally understood evolutionary history of certain ion channels -- proteins critical for electrical signaling in the nervous system. The study shows that the Shaker family of ion channels were present in microscopic single cell organisms well before the common ancestor of all animals and thus before the origin of the nervous system.
Published Starvation and adhesion drive formation of keratinocyte patterns in skin
(via sciencedaily.com) Original source Cell-cell adhesion-induced patterning in keratinocytes can be explained by just starvation and strong adhesion researchers find.
Published Study reveals oleoyl-ACP-hydrolase underpins lethal respiratory viral disease
(via sciencedaily.com) Original source Respiratory infections can be severe, even deadly, in some individuals, but not in others. Scientists have gained new understanding of why this is the case by uncovering an early molecular driver that underpins fatal disease. Oleoyl-ACP-hydrolase (OLAH) is an enzyme involved in fatty acid metabolism. A study shows that OLAH drives severe disease outcomes.
Published Researchers ID body's 'quality control' regulator for protein folding
(via sciencedaily.com) Original source Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-like complexity that regulate essential cellular functions, the result can lead to one of a multitude of serious diseases ranging from emphysema and cystic fibrosis to Alzheimer's disease. Fortunately, our bodies have a quality-control system that identifies misfolded proteins and marks them either for additional folding work or destruction, but how, exactly, this quality-control process functions is not entirely known. Researchers have now made a major leap forward in our understanding of how this quality-control system works by discovering the 'hot spot' where all the action takes place.
Published How mortal filaments' self-assemble and maintain order: Align or die
(via sciencedaily.com) Original source A previously unknown mechanism of active matter self-organization essential for bacterial cell division follows the motto 'dying to align': Misaligned filaments 'die' spontaneously to form a ring structure at the center of the dividing cell. The work could find applications in developing synthetic self-healing materials.
Published Taking a 'one in a million' shot to tackle dopamine-linked brain disorders
(via sciencedaily.com) Original source With the help of a tiny, transparent worm called Caenorhabditis elegans, researchers have identified novel players in dopamine signaling by taking advantage of a powerful platform generated via the Million Mutation Project (MMP) for the rapid identification of mutant genes based on their functional impact. They can seek insights from simpler organisms whose genes bear striking similarity to those found in humans and where opportunities for genetic insights to disease can be pursued more efficiently and inexpensively.
Published An appetizer can stimulate immune cells' appetite, a boon for cancer treatments
(via sciencedaily.com) Original source The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among this force is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and cancer. Macrophages have a delicate task. It's crucial that they ignore healthy cells while on patrol, otherwise they could trigger an autoimmune response while performing their duties.
Published Largest protein yet discovered builds algal toxins
(via sciencedaily.com) Original source While seeking to unravel how marine algae create their chemically complex toxins, scientists have discovered the largest protein yet identified in biology. Uncovering the biological machinery the algae evolved to make its intricate toxin also revealed previously unknown strategies for assembling chemicals, which could unlock the development of new medicines and materials.
Published Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy
(via sciencedaily.com) Original source Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient. Now, researchers have developed a machine-learning approach that promises to speed up AAV engineering for gene therapy. The tool helps researchers engineer the protein shells of AAVs, called capsids, to have multiple desirable traits, such as the ability to deliver cargo to a specific organ but not others or to work in multiple species. Other methods only look for capsids that have one trait at a time.
Published Bacteria encode hidden genes outside their genome--do we?
(via sciencedaily.com) Original source A 'loopy' discovery in bacteria is raising fundamental questions about the makeup of our own genome -- and revealing a potential wellspring of material for new genetic therapies.
Published Researchers develop AI model that predicts the accuracy of protein--DNA binding
(via sciencedaily.com) Original source A new artificial intelligence model can predict how different proteins may bind to DNA.