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Categories: Biology: Evolutionary, Chemistry: Organic Chemistry
Published New approach in the synthesis of complex natural substances
(via sciencedaily.com) Original source Many natural substances possess interesting characteristics, and can form the basis of new active compounds in medicine. Terpenes, for example, are a group of substances, some of which are already used in therapies against cancer, malaria or epilepsy. They are found as fragrances in cosmetics or as flavorings in food, and form the basis of new medications: Terpenes are natural substances that occur in plants, insects and sea sponges. They are difficult to produce synthetically. However, chemists are now introducing a new method of synthesis.
Published Researchers create new chemical compound to solve 120-year-old problem
(via sciencedaily.com) Original source Chemists have created a highly reactive chemical compound that has eluded scientists for more than 120 years. The discovery could lead to new drug treatments, safer agricultural products, and better electronics.
Published Scientists solve chemical mystery at the interface of biology and technology
(via sciencedaily.com) Original source Organic electrochemical transistors (OECTs) allow current to flow in devices like implantable biosensors. But scientists long knew about a quirk of OECTs that no one could explain: When an OECT is switched on, there is a lag before current reaches the desired operational level. When switched off, there is no lag. Current drops immediately. Researchers report that they have discovered the reason for this activation lag, and in the process are paving the way to custom-tailored OECTs for a growing list of applications in biosensing, brain-inspired computation and beyond.
Published Researchers parse oddity of distantly related bats in Solomon Islands that appear identical
(via sciencedaily.com) Original source A study of body size in leaf-nosed bats of the Solomon Islands has revealed surprising genetic diversity among nearly indistinguishable species on different islands.
Published Unlocking the genetic mysteries behind plant adaptation: New insights into the evolution of a water-saving trait in the pineapple family (bromeliaceae)
(via sciencedaily.com) Original source Researchers have achieved a breakthrough in understanding how genetic drivers influence the evolution of a specific photosynthesis mechanism in Tillandsia (air plants). This sheds light on the complex actions that cause plant adaptation and ecological diversity.
Published Research on RNA editing illuminates possible lifesaving treatments for genetic diseases
(via sciencedaily.com) Original source The research explores how CRISPR can be used to edit RNA.
Published When does a conductor not conduct?
(via sciencedaily.com) Original source A new study uncovers a switchable, atomically-thin metal-organic material that could be used in future low-energy electronic technologies. The study shows that electron interactions in this material create an unusual electrically-insulating phase in which electrons are 'frozen'. By reducing the population of electrons, the authors are able to unfreeze the remaining electrons, allowing for controlled transitions between insulating and electrically-conductive phases: the key to the on-off binary operations of classical computing.
Published Getting dynamic information from static snapshots
(via sciencedaily.com) Original source Researchers have created TopicVelo, a powerful new method of using the static snapshots from scRNA-seq to study how cells and genes change over time. This will help researchers better study how embryos develop, cells differentiate, cancers form, and the immune system reacts.
Published Surprising evolutionary pattern in yeast study
(via sciencedaily.com) Original source Research study reports intriguing findings made through innovative artificial intelligence analysis about yeasts -- small fungi that are key contributors to biotechnology, food production, and human health. These findings on simple yeast organisms not only challenge widely accepted ideas about yeast evolution, but also provides access to an incredibly rich yeast analysis dataset that could have major implications for future evolutionary biology and bioinformatics research for years to come.
Published AI deciphers new gene regulatory code in plants and makes accurate predictions for newly sequenced genomes
(via sciencedaily.com) Original source Elucidating the relationship between the sequences of non-coding regulatory elements and their target genes is key to understanding gene regulation and its variation between plant species and ecotypes. Now, an international research team developed deep learning models that link gene sequence data with mRNA copy number for several plant species and predicted the regulatory effect of gene sequence variation.
Published These jacks-of-all-trades are masters, too: Yeast study helps answer age-old biology question
(via sciencedaily.com) Original source The results suggest that internal -- not external -- factors are the primary drivers of variation in the types of carbon yeasts can eat, and the researchers found no evidence that metabolic versatility, or the ability to eat different foods, comes with any trade-offs. In other words, some yeasts are jacks-of-all-trades and masters of each.
Published A shortcut for drug discovery
(via sciencedaily.com) Original source For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.
Published Curiosity promotes biodiversity
(via sciencedaily.com) Original source Cichlid fishes exhibit differing degrees of curiosity. The cause for this lies in their genes, as reported by researchers. This trait influences the cichlids' ability to adapt to new habitats.
Published Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments
(via sciencedaily.com) Original source A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.
Published The longer spilled oil lingers in freshwater, the more persistent compounds it produces
(via sciencedaily.com) Original source Oil is an important natural resource for many industries, but it can lead to serious environmental damage when accidentally spilled. While large oil spills are highly publicized, every year there are many smaller-scale spills into lakes, rivers and oceans. The longer that oil remains in freshwater, the more chemical changes it undergoes, creating products that can persist in the environment.
Published The secret to saving old books could be gluten-free glues
(via sciencedaily.com) Original source 'Bookworm' is a cute thing to call a voracious reader, but actual bookworms -- as well as microorganisms and time -- break down the flour pastes commonly used to keep old publications in one piece. Now, researchers have analyzed the proteins in wheat-based glues applied in historic bookbinding to provide insights on their adhesiveness and how they degrade. This information could help conservators restore and preserve treasured tomes for future generations.
Published Color variants in cuckoos: The advantages of rareness
(via sciencedaily.com) Original source Every cuckoo is an adopted child -- raised by foster parents, into whose nest the cuckoo mother smuggled her egg. The cuckoo mother is aided in this subterfuge by her resemblance to a bird of prey. There are two variants of female cuckoos: a gray morph that looks like a sparrowhawk, and a rufous morph. Male cuckoos are always gray.
Published How parasites shape complex food webs
(via sciencedaily.com) Original source A new study sheds light on how parasites, often overlooked, can dramatically affect the balance between predator and prey populations. Researchers developed a groundbreaking mathematical framework that predicts when predators, prey, and parasites can coexist, considering factors like random fluctuations and parasite effects on both populations. This research provides a valuable tool for conservation by helping predict how parasites influence ecosystem resilience and informing strategies to protect vulnerable species.
Published Biophysics: Testing how well biomarkers work
(via sciencedaily.com) Original source Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.
Published A chemical mystery solved -- the reaction explaining large carbon sinks
(via sciencedaily.com) Original source A mystery that has puzzled the scientific community for over 50 years has finally been solved. A team has discovered that a certain type of chemical reaction can explain why organic matter found in rivers and lakes is so resistant to degradation.