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Categories: Biology: Developmental, Biology: Evolutionary
Published A unified account of Darwinism's varieties
(via sciencedaily.com) Original source A new article examines the question of what Darwinism is and how its nonscientific uses relate to the scientific theory of evolution. The authors observe that while some people claim Darwinism's meaning should be limited to scientific content, others call for its abolition altogether. The authors propose a unified account of these varieties of Darwinism.
Published Bringing back an ancient bird
(via sciencedaily.com) Original source Using ancient DNA extracted from the toe bone of a museum specimen, biologists have sequenced the genome of an extinct, flightless bird called the little bush moa, shedding light into an unknown corner of avian genetic history. The work is the first complete genetic map of the turkey-sized bird whose distant living cousins include the ostrich, emu, and kiwi.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Researchers have unveiled a new method to manipulate cell movement in embryos
(via sciencedaily.com) Original source Scientists have developed a new method that can manipulate the movement of embryonic cells using short-time attractors.
Published How killifish embryos use suspended animation to survive over 8 months of drought
(via sciencedaily.com) Original source The African turquoise killifish lives in ephemeral ponds in Zimbabwe and Mozambique. To survive the annual dry season, the fish's embryos enter a state of extreme suspended animation or 'diapause' for approximately 8 months. Now, researchers have uncovered the mechanisms that enabled the killifish to evolve this extreme survival state.
Published Echidnapus identified from an 'Age of Monotremes'
(via sciencedaily.com) Original source Australian researchers have found evidence of the oldest known platypus and a new species, dubbed 'echidnapus', which has a platypus-like anatomy alongside features that more closely resemble an echidna.
Published Investigating the origin of circatidal rhythms in freshwater snails
(via sciencedaily.com) Original source While most organisms have biological clocks synchronized with the day-night cycle (circadian rhythms), marine animals in tidal areas have also developed circatidal rhythms to align with the tidal cycle. Comparing the activity and genetic expression of snails from tidal and non-tidal areas, researchers demonstrate that circatidal rhythms develop as snails adapt to tidal environments. These findings highlight the flexibility of biological clocks, enabling organisms to adjust their rhythms according to the environment.
Published On repeat: Biologists observe recurring evolutionary changes, over time, in stick insects
(via sciencedaily.com) Original source An evolutionary biologist reports evidence of repeatable evolution in populations of stick insects.
Published Entomologist sheds light on 250-year-old mystery of the German cockroach
(via sciencedaily.com) Original source Entomologists have solved the 250-year-old origin puzzle of the most prevalent indoor urban pest insect on the planet: the German cockroach. The team's research findings, representing the genomic analyses of over 280 specimens from 17 countries and six continents, show that this species evolved some 2,100 years ago from an outdoor-living species in Asia.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development
(via sciencedaily.com) Original source Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Birdsong and human voice built from same genetic blueprint
(via sciencedaily.com) Original source Humans have been long fascinated by bird song and the cacophony of other avian sounds -- from coos and honks to quacks and peeps. But little is known about how the unique vocal organ of birds -- the syrinx -- varies from species to species or its deeper evolutionary origins. A trio of recent studies is changing that. The studies include high-resolution anatomical scans of syrinxes from hummingbirds and ostriches -- the world's smallest and largest bird species -- and the discovery that the syrinx and larynx, the vocal organ of reptiles and mammals, including humans, share the same developmental programming.
Published Novel approach to interrogate tissue-specific protein-protein interactions
(via sciencedaily.com) Original source Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published Tracking down the genetic causes of lupus to personalize treatment
(via sciencedaily.com) Original source Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.
Published Sexual parasitism helped anglerfish invade the deep sea during a time of global warming
(via sciencedaily.com) Original source Members of the vertebrate group including anglerfishes are unique in possessing a characteristic known as sexual parasitism, in which males temporarily attach or permanently fuse with females to mate. Now, researchers show that sexual parasitism arose during a time of major global warming and rapid transition for anglerfishes from the ocean floor to the deep, open sea.
Published Gene could unlock big wheat yields for a growing population
(via sciencedaily.com) Original source A study has discovered molecular pathways regulated by a gene traditionally used to control wheat-flowering behavior could be altered to achieve greater yields.
Published Exploring diversity in cell division
(via sciencedaily.com) Original source Animals and fungi predominantly use two different modes of cell division -- called open and closed mitosis, respectively. A new study has shown that different species of Ichthyosporea -- marine protists that are close relatives of both animals and fungi -- use either open and closed mitosis, closely correlated to whether the species has multinucleate life cycle stages. The study demonstrates the way animals do cell division might have evolved long before animals themselves did and how this is linked to an organism's life cycle.
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
(via sciencedaily.com) Original source Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published New AI accurately predicts fly behavior
(via sciencedaily.com) Original source Researchers trained an AI model to accurately predict male fruit flies' courtship behavior in response to any sight of a female. This breakthrough offers new insight into how the brain processes visual data and may someday pave the way for artificial vision technology.
Published Study finds widespread 'cell cannibalism,' related phenomena across tree of life
(via sciencedaily.com) Original source Researchers describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoebas to complex multicellular animals.