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Categories: Biology: Developmental, Biology: Evolutionary

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Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.

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It is generally believed that, for millions of years, bats and the insects they hunt at night have adapted to each other in an evolutionary arms race to become better at finding or avoiding each other. Now, a new study shows that this may not be the case at all.

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Cyanobacteria are a key species in Earth's history, as they introduced atmospheric oxygen for the first time. The analysis of their evolution therefore provides important insights into the formation of modern aerobic ecosystems. For a long time, a certain type of fossil lipid, so-called 2-methylhopanes, was considered to be an important biomarker for Cyanobacteria in sediments, some of which are hundreds of millions of years old. However, this came into doubt when it turned out that not only Cyanobacteria but also Alphaproteobacteria are genetically capable of producing these lipids.

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Noctilionoid bat species evolved wildly different faces as they adapted to exploit diverse food sources -- including insects, fruit, nectar, blood and fish. New research shows that those adaptations include dramatic, but also consistent, modifications to tooth number, size, shape and position.

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Researchers have made a significant discovery by identifying and characterizing three novel species within the Minorisa genus of marine picoplankton. Before this study, only one species of Minorisa was recognized. This finding reveals previously unseen diversity of Minorisa, thereby enhancing species identification and our understanding of its ecological functions in marine ecosystems.  

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An electric knifefish shimmies in the water for the same reason a dog sniffs or a human glances around a new place -- to make sense of their surroundings. For the first time, scientists demonstrate that a wide range of organisms, even microbes, perform the same pattern of movements in order to sense the world.

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Scientists have discovered that even among the sulfur-cycling microbes that are responsible for the 'rotten egg gas' smell in salt marsh air, diversity extends all the way to genomes and even to individual nucleotides.

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A team of researchers has gained new insights into the respiratory system of fruit flies -- the so-called tracheal system -- which could be important for future research into aneurysms. Scientists carried out genetic, cell biological and biochemical studies on Drosophila embryos. They found that the cells in the fruit fly's tracheal system are connected to the extracellular matrix by the proteins Dumpy and Piopio.

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New research reveals how the bacteria strain Wolbachia pipientis enhances the fertility of the insects it infects, an insight that could help scientists increase the populations of mosquitoes that do not carry human disease.

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Scientists studied the genomes of 30 kingfisher species to try to identify the genes that allow kingfishers to dive headfirst into water without huring their brains. The researchers found that the diving birds have unusual mutations to the genes that produce tau: a protein that helps stabilize tiny structures in the brain, but which can build up in humans with traumatic brain injuries or Alzheimer's disease. The researchers suspect that these variations in the kingfishers' tau proteins might protect their brains when they dive.

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Harnessing new advances in genomic surveillance technology could help detect the rise of deadly 'superbugs'.

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A team of researchers has developed a software tool that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However, there are some challenges in the use of CRISPR. The new analysis system overcomes these challenges and allows researchers to perform safer on- and off-target assessments without a reference genome. It holds the potential for applications in medicine, agriculture, and biological research.

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Urban environments have become hotspots for understanding how rapid evolution occurs in response to extreme environmental changes. These habitats exert selective pressures on resident organisms that impact their evolutionary trajectories. Recently, researchers investigated how the creeping woodsorrel plant might adapt in response to elevated temperatures that result from urbanization. Understanding these effects can help predict evolutionary traits to manage plant evolution in the face of shifting climatic conditions.

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Researchers are studying the dramatic physical transformation that some insects undergo to give birth to live young. This includes suppressing their immune systems to accommodate babies, which is something some insects and people have in common. Understanding how these systems work can help improve treatments for fibromyalgia and other immune disorders. An international team of researchers has examined the complex structural and physiological changes that take place in Hawaii's beetle-mimic cockroaches, which give birth to live young.

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A plant geneticist and computational biologist teamed up to decipher the unpredictability of natural and engineered mutations in tomatoes. They discovered some combinations of mutations behave as expected while others are more erratic. Their work may help scientists find some order in the chaos of evolution and genome editing.

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Whether a mouse is a good or bad parent can be traced back to imprinted genes in key neurons in the 'parenting hub' in the brain, according to a new study.

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Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations. Their findings can help understand GPCRs better and could pave the way to therapeutic breakthroughs for many diseases.

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A research team has discovered that parasites manipulate their hosts using stolen genes that they likely acquired through a phenomenon called horizontal gene transfer.

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New soft, implantable fibers can deliver light to major nerves through the body. They are an experimental tool for scientists to explore the causes and potential treatments for peripheral nerve disorders in animal models.

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Study creates a mosquito family tree to better understand disease transmission and host choice.