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Categories: Biology: Evolutionary, Chemistry: Biochemistry

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In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.

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Researchers have succeeded in developing a DNA-based molecular controller. Crucially, this controller enables the autonomous assembly and disassembly of molecular robots, as opposed to manually directing it.

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An international research team has uncovered a new insight into human evolution by comparing humans' hearts with those of other great apes.

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Scientists address decades-long problem in the field of single-molecule fluorescence resonance energy transfer, paving the way for more accurate experiments.

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Researchers have made a significant breakthrough in how to enable and exploit ultra-fast spin behavior in ferromagnets. The research paves the way for ultra-high frequency applications.

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Researchers have developed new chemistry to achieve commercially relevant stability and performance for perovskite solar cells.

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With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.

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A suite of three innovations enables high-resolution, high-throughput imaging of human brain tissue at a full range of scales and mapping connectivity of neurons at single cell resolution. To demonstrate the advance, researchers compared a brain region in an Alzheimer's and a control sample.

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Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life. The genetic basis for these exceptional abilities remains elusive. Researchers have now successfully edited genes using the CRISPR technique in a highly resilient tardigrade species previously impossible to study with genome-editing tools. The successful delivery of CRISPR to an asexual tardigrade species directly produces gene-edited offspring. The design and editing of specific tardigrade genes allow researchers to investigate which are responsible for tardigrade resilience and how such resilience can work.

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Paleontologists have identified a new genus of fossil goby, revealing evolutionary secrets of a lineage that stretches back millions of years.

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Engineers have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors. This approach has shown promise in mice, where it inhibited the growth and spread of tumors that had metastasized to the lungs, thereby boosting survival rates compared to control treatments.

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Louisiana's southeastern corridor is sometimes known colloquially as 'Cancer Alley' for its high cancer incidence rates connected to industrial air pollution. Most of the region's air pollution-related health risks are attributed to ethylene oxide, a volatile compound used to make plastics and sterilize medical equipment. Researchers measured concerning levels of ethylene oxide in this area with mobile optical instruments, a technique they say could improve health risk assessments.

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In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called 'symmetry breaking.'

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A team aims to improve options for renewable energy storage through work on an emerging technology -- liquids for hydrogen storage.

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Researchers have successfully used a new robot system to improve treatment for debilitating eye disease.

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Scientists have developed an artificial intelligence (AI)-powered system to track tiny devices that monitor markers of disease in the gut. Devices using the novel system may help at-risk individuals monitor their gastrointestinal (GI) tract health at home, without the need for invasive tests in hospital settings.

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Inspired by the material that makes up oyster and abalone shells, engineers have created a new cement composite that is 17 times more crack-resistant than standard cement and 19 times more able to stretch and deform without breaking. The findings could eventually help increase the crack resistance of a wide range of brittle ceramic materials from concrete to porcelain.

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The need to transition away from fossil fuels to more sustainable energy production is critical. That's why a team of researchers is looking at a potential power source that not only produces no carbon emissions but removes carbon as it works: algae.

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To help probe the mystery of how brains control movement, scientists have created a virtual rat with an artificial brain that can move around just like a real rodent. The researchers found that activations in the virtual control network accurately predicted neural activity measured from the brains of real rats producing the same behaviors.

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Researchers are breaking through the difficulties of robotic recognition of various common, yet complex, items. Their layered sensor is equipped with material detection at the surface and pressure sensitivity at the bottom, with a porous middle layer sensitive to thermal changes. An efficient cascade classification algorithm rules out object types in order, from easy to hard, starting with simple categories like empty cartons before moving on to orange peels or scraps of cloth.