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Categories: Biology: Evolutionary, Chemistry: Biochemistry
Published Next-generation treatments hitch a ride into cancer cells
(via sciencedaily.com) Original source Researchers found that a new activator called L687 induces cancer cells to accept delivery of antisense oligonucleotide (ASO) drugs. These drugs can treat cancer by blocking the transfer of messages from genes that encourage cancer growth. Previous methods to deliver ASOs into cells had only limited success. This research will help accelerate the development and delivery of novel ASO cancer therapies.
Published Millions of gamers advance biomedical research
(via sciencedaily.com) Original source 4.5 million gamers around the world have advanced medical science by helping to reconstruct microbial evolutionary histories using a minigame included inside the critically and commercially successful video game, Borderlands 3. Their playing has led to a significantly refined estimate of the relationships of microbes in the human gut. The results of this collaboration will both substantially advance our knowledge of the microbiome and improve on the AI programs that will be used to carry out this work in future.
Published Evolution's recipe book: How 'copy paste' errors cooked up the animal kingdom
(via sciencedaily.com) Original source A series of whole genome and gene duplication events that go back hundreds of millions of years have laid the foundations for tissue-specific gene expression, according to a new study. The 'copy-paste' errors allowed animals to keep one copy of their genome or genes for fundamental functions, while the second copy could be used as raw material for evolutionary innovation. Events like these, at varying degrees of scale, occurred constantly throughout the bilaterian evolutionary tree and enabled traits and behaviours as diverse as insect flight, octopus camouflage and human cognition.
Published Researchers study effects of solvation and ion valency on metallopolymers
(via sciencedaily.com) Original source Researchers analyzed the effects of solvation and ion valency on metallopolymers, with implications for critical materials recovery and recycling, and environmental remediation.
Published How seaweed became multicellular
(via sciencedaily.com) Original source A deep dive into macroalgae genetics has uncovered the genetic underpinnings that enabled macroalgae, or 'seaweed,' to evolve multicellularity. Three lineages of macroalgae developed multicellularity independently and during very different time periods by acquiring genes that enable cell adhesion, extracellular matrix formation, and cell differentiation, researchers report. Surprisingly, many of these multicellular-enabling genes had viral origins. The study, which increased the total number of sequenced macroalgal genomes from 14 to 124, is the first to investigate macroalgal evolution through the lens of genomics.
Published Innovative antiviral defense with new CRISPR tool
(via sciencedaily.com) Original source The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate. Scientists have devised a solution: Cas13d-NCS. This new molecular tool allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses. This advancement opens doors for precision medicine and proactive viral defense strategies.
Published A new spin on organic shampoo makes it sudsier, longer lasting
(via sciencedaily.com) Original source While there's no regulation in the U.S. for what's in organic shampoos, they tend to contain ingredients perceived as safe or environmentally friendly. However, these 'clean' shampoos separate and spoil faster than those made with synthetic stabilizers and preservatives. Now, researchers demonstrate that a simple process -- spinning organic shampoo at high speeds -- improved the final products' shelf lives and ability to clean hair.
Published New AI method captures uncertainty in medical images
(via sciencedaily.com) Original source Tyche is a machine-learning framework that can generate plausible answers when asked to identify potential disease in medical images. By capturing the ambiguity in images, the technique could prevent clinicians from missing crucial information that could inform diagnoses.
Published Oxidant pollutant ozone removes mating barriers between fly species
(via sciencedaily.com) Original source Researchers show that ozone levels, such as those found in many places on hot summer days today, destroy the sex pheromones of fruit fly species. As a result, some natural mating boundaries maintained by species-specific pheromones no longer exist. The research team has shown in experiments that flies of different species mate when exposed to ozone and produce hybrid offspring. Since most of these offspring are unable to reproduce, the results could provide another explanation for the global decline of insects.
Published Cloud engineering could be more effective 'painkiller' for global warming than previously thought
(via sciencedaily.com) Original source Cloud 'engineering' could be more effective for climate cooling than previously thought, because of the increased cloud cover produced, new research shows.
Published Synthetic platelets stanch bleeding, promote healing in animal models
(via sciencedaily.com) Original source Researchers have developed synthetic platelets that can be used to stop bleeding and enhance healing at the site of an injury. The researchers have demonstrated that the synthetic platelets work well in animal models but have not yet begun clinical trials in humans.
Published Geobiology: New placozoan habitat discovered
(via sciencedaily.com) Original source Traces of DNA in the stomachs of predatory snails give a team og geobiologists new insights into the ecology of placozoans.
Published A new coating method in mRNA engineering points the way to advanced therapies
(via sciencedaily.com) Original source Researchers have developed a novel method of adding polyethylene glycol molecules to engineered groups of messenger RNAs called 'mRNA polyplexes', which enable the cells that receive them to produce specific proteins. This technique allows greater control of the site in the body to which the polyplexes are delivered, significantly advancing the field of therapeutic mRNA technologies, with applications in vaccine development and the treatment of cancer and other diseases.
Published 3D mouth of an ancient jawless fish suggests they were filter-feeders, not scavengers or hunters
(via sciencedaily.com) Original source Early jawless fish were likely to have used bony projections surrounding their mouths to modify the mouth's shape while they collected food. Experts have used CT scanning techniques to build up the first 3D pictures of these creatures, which are some of the earliest vertebrates (animals with backbones) in which the mouth is fossilized. Their aim was to answer questions about feeding in early vertebrates without jaws in the early Devonian epoch -- sometimes called the Age of Fishes -- around 400 million years ago.
Published New strategy for assessing the applicability of reactions
(via sciencedaily.com) Original source Chemists show that a machine-based method prevents widespread 'bias' in chemical publications.
Published Revolutionary molecular device unleashes potential for targeted drug delivery and self-healing materials
(via sciencedaily.com) Original source In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.
Published New device gathers, stores electricity in remote settings
(via sciencedaily.com) Original source Wirelessly connected devices perform an expanding array of applications, such as monitoring the condition of machinery and remote sensing in agricultural settings. These applications hold much potential for improving the efficiency, but how do you power these devices where reliable electrical sources are not available? Research points to a possible solution in the form of a novel type of battery.
Published Birdfeeders are designed to keep unwanted guests away
(via sciencedaily.com) Original source The first birdfeeders were made in the 19th century, and their design rapidly evolved during the 20th century. Researchers at the consider the evolution of the birdfeeder to be an example of multispecies design, where unwanted guests have shaped the human-made artifact.
Published Could new technique for 'curving' light be the secret to improved wireless communication?
(via sciencedaily.com) Original source A study that could help revolutionize wireless communication introduces a novel method to curve terahertz signals around an obstacle.
Published Subterranean storage of hydrogen
(via sciencedaily.com) Original source Scientists are using computer simulations and laboratory experiments to see if depleted oil and natural gas reservoirs can be used for storing carbon-free hydrogen fuel. Hydrogen is an important clean fuel: It can be made by splitting water using solar or wind power, it can be used to generate electricity and power heavy industry, and it could be used to power fuel-cell-based vehicles. Additionally, hydrogen could be stored for months and used when energy needs outpace the supply delivered by renewable energy sources.