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Categories: Biology: Molecular, Chemistry: Organic Chemistry

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In a new study, researchers have discovered how a system of proteins, called TamAB, helps Salmonella survive under the harsh conditions inside macrophages.

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A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.

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Oxidative coupling of methane (OCM) is now one step closer to leaving the lab and entering the real world. Researchers have developed an OCM catalyst that exceeds 30 percent when it comes to the production of ethylene.

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Researchers have engineered one of the world's first yeast cells able to harness energy from light, expanding our understanding of the evolution of this trait -- and paving the way for advancements in biofuel production and cellular aging.

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Researchers have developed a unique catalyst that promises to revolutionize drug synthesis. It overcomes a common problem associated with the production of drugs from ketones. Using their catalyst, the researchers synthesized a key component of the commonly used incontinence drug oxybutynin. Their results underscore the potential of the catalyst to improve drug discovery and development.

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Researchers use light-reactive molecules to influence the acidity of a liquid and thereby capture of carbon dioxide. They have developed a special mixture of different solvents to ensure that the light-reactive molecules remain stable over a long period of time. Conventional carbon capture technologies are driven by temperature or pressure differences and require a lot of energy. This is no longer necessary with the new light-based process.

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Researchers are using crystallography to gain a better understanding of how proteins shapeshift. The knowledge can provide valuable insight into stopping and treating diseases.

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A research team investigated how the emergence of the first living systems from inert geological materials happened on the Earth, more than 3.5 billion years ago. Scientists found that by mixing hydrogen, bicarbonate, and iron-rich magnetite under conditions mimicking relatively mild hydrothermal vent results in the formation of a spectrum of organic molecules, most notably including fatty acids stretching up to 18 carbon atoms in length.

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The sun has just set on a quiet mudflat in Australia's Northern Territory; it'll set again in another 19 hours. A young moon looms large over the desolate landscape. No animals scurry in the waning light. No leaves rustle in the breeze. No lichens encrust the exposed rock. The only hint of life is some scum in a few puddles and ponds. And among it lives a diverse microbial community of our ancient ancestors.

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With human retinas grown in a petri dish, researchers discovered how an offshoot of vitamin A generates the specialized cells that enable people to see millions of colors, an ability that dogs, cats, and other mammals do not possess. The findings increase understanding of color blindness, age-related vision loss, and other diseases linked to photoreceptor cells. They also demonstrate how genes instruct the human retina to make specific color-sensing cells, a process scientists thought was controlled by thyroid hormones.

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Scientists have developed a way to convert carbon dioxide (CO2), a potent greenhouse gas, into carbon nanofibers, materials with a wide range of unique properties and many potential long-term uses. Their strategy uses tandem electrochemical and thermochemical reactions run at relatively low temperatures and ambient pressure and could successfully lock carbon away to offset or even achieve negative carbon emissions.

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The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.

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Water samples from 20 sites were tested using a panel of immortalized human cell lines corresponding to the liver, kidney and brain to measure cytotoxicity. Results show that each control toxin induced a consistent pattern of cytotoxicity in the panel of human cell lines assayed. Known toxins were seen only during blooms. Because cell toxicity was seen in the absence of blooms, it suggests that there might be either emergent toxins or a combination of toxins present at those times. Findings suggest that other toxins with the potential to be harmful to human health may be present in the lagoon.

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Researchers have resolved a problem that has limited the environmental sustainability of peracid synthesis. By judicious choice of the solvent and light input, approximately room-temperature autoxidation of aldehydes proceeds in a manner that results in industrially useful peracids or carboxylic acids. This work is an important advance in green chemistry that will help minimize the carbon footprint of the chemical industry.

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In nature, organic molecules are either left- or right-handed, but synthesizing molecules with a specific 'handedness' in a lab is hard to do. Make a drug or enzyme with the wrong 'handedness,' and it just won't work. Now chemists are getting closer to mimicking nature's chemical efficiency through computational modeling and physical experimentation.

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Phosphorus is essential for undisturbed plant growth and development. However, in many soils, phosphorus is only poorly available. One mechanism used by plants to increase phosphorus availability is the release of malate, an organic acid, which can form complexes with iron or aluminium in the soil, thereby liberating sorbed phosphate. However, this response can also result in iron overaccumulation, which can inhibit root growth.

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The widely used dry-cleaning and degreasing solvent perc can be converted to useful chemicals by a new clean, safe and inexpensive procedure. The discovery using on-demand UV activation may open the path to upcycling perc and thus contribute to a more sustainable society.

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New research has revealed how light can be used to destroy infectious coronavirus particles that contaminate surfaces. Scientists are interested in how environments, such as surgeries, can be thoroughly disinfected from viruses such as SARS-CoV-2 that caused the COVID-19 pandemic.

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A new discovery takes its inspiration from Greek mythology. The compound is described as a chimera, because it battles a toxic cause of Parkinson's in two ways.

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Chemists have presented a new approach in which a single carbon atom is inserted into the carbon skeleton of cyclic compounds in order to adjust the ring size. The method could be relevant, for example, for the production of active ingredients in new pharmaceutical products.