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Categories: Biology: Molecular, Chemistry: Organic Chemistry
Published Shedding light on the synthesis of sugars before the origin of life
(via sciencedaily.com) Original source Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability on early Earth is unclear since these molecules are unstable. Now, researchers reveal a chemical pathway compatible with early Earth conditions, by which C6 aldonates could have acted as a source of pentoses without the need for enzymes. Their findings provide clues about primitive biochemistry and bring us closer to understanding life's origin.
Published PicoRuler: Molecular rulers for high-resolution microscopy
(via sciencedaily.com) Original source A team presents a groundbreaking advance for the world of high-resolution fluorescence microscopy: The innovative method enables researchers for the first time to use biomolecules as molecular rulers to calibrate the latest super-resolution microscopy methods, which have a resolution of just a few nanometers.
Published Researchers reveal new process for making anhydride chemical compounds
(via sciencedaily.com) Original source A collaborative research team has discovered a new process for making anhydrides that promises improvements in costs and sustainability.
Published Clever dosage control mechanism of biallelic genes
(via sciencedaily.com) Original source Researchers have uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each chromosome. A study identified the epigenetic regulator MSL2 an 'anti-monoallelic' factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.
Published Key protein in blood vessel's growth identified
(via sciencedaily.com) Original source New research identifies the class II PI3K-C2b protein, a member of the PI3 family of kinases, as one of the key regulators of blood vessels growth in humans and other mammals. Mutations in these family of proteins may lead to vascular malformations and the precise understanding of the whole process is instrumental in opening the door to new therapeutic approaches in the future.
Published Artificial intelligence paves way for new medicines
(via sciencedaily.com) Original source Researchers have developed an AI model that can predict where a drug molecule can be chemically altered.
Published Releasing brakes on biocatalysis
(via sciencedaily.com) Original source Enzymes from microorganisms can produce hydrogen (H2) under certain conditions, which makes them potential biocatalysts for biobased H2 technologies. In order to make this hydrogen production efficient, researchers are trying to identify and eliminate possible limiting factors. These include formaldehyde, which occurs naturally as a metabolic product in cells and inhibits the particularly efficient [FeFe] hydrogenase.
Published Greener solution powers new method for lithium-ion battery recycling
(via sciencedaily.com) Original source Used lithium-ion batteries from cell phones, laptops and a growing number of electric vehicles are piling up, but options for recycling them remain limited mostly to burning or chemically dissolving shredded batteries. Researchers have improved on approaches that dissolve the battery in a liquid solution in order to reduce the amount of hazardous chemicals used in the process. This simple, efficient and environmentally-friendly solution overcomes the main obstacles presented by previous approaches.
Published Scientists harness flower 'super power' to pave the way for new drug treatments
(via sciencedaily.com) Original source Researchers have developed a way of joining up the head and tail of a protein, making it more stable and easier to get into cells.
Published Scientist discovers potential brain link between stress, emotional eating
(via sciencedaily.com) Original source Scientists describe how they identified a molecule that may trigger over-consumption of comfort foods after a threatening event.
Published New clues into the head-scratching mystery of itch
(via sciencedaily.com) Original source Scientists show for the first time that bacteria can cause itch by activating nerve cells in the skin. The findings can inform new therapies to treat itch that occurs in inflammatory skin conditions like eczema and dermatitis.
Published Chemists use oxygen, copper 'scissors' to make cheaper drug treatments possible
(via sciencedaily.com) Original source Researchers have devised a way to produce chemicals used in medicine and agriculture for a fraction of the usual cost. Using oxygen as a reagent and copper as a catalyst to break organic molecules' carbon-carbon bonds and convert them into amines, which are widely used in pharmaceuticals. Traditional metal catalysis uses expensive metals such as platinum, silver, gold and palladium, but the researchers used oxygen and copper -- an abundant base metal.
Published Nutrient found in beef and dairy improves immune response to cancer
(via sciencedaily.com) Original source Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study.
Published Team discovers rules for breaking into Pseudomonas
(via sciencedaily.com) Original source Researchers report that they have found a way to get antibacterial drugs through the nearly impenetrable outer membrane of Pseudomonas aeruginosa, a bacterium that -- once it infects a person -- is notoriously difficult to treat.
Published New method for determining the water content of water-soluble compounds
(via sciencedaily.com) Original source Researchers have developed a new method for the accurate determination of the water content of water-soluble compounds. This plays a significant role in various areas, including determining drug dosages.
Published Laser-powered 'tweezers' reveal universal mechanism viruses use to package up DNA
(via sciencedaily.com) Original source Researchers have used laser-powered ‘optical tweezers’ to reveal a universal motor mechanism used by viruses for packaging their DNA into infectious particles.
Published Effect of aerosol particles on clouds and the climate captured better
(via sciencedaily.com) Original source Global measurements and model calculations show that the complex relationship between the chemistry and climate impact of aerosol particles can be successfully captured by a simple formula.
Published Unearthing how a carnivorous fungus traps and digests worms
(via sciencedaily.com) Original source A new analysis sheds light on the molecular processes involved when a carnivorous species of fungus known as Arthrobotrys oligospora senses, traps and consumes a worm.
Published Coffee grounds may hold key to preventing neurodegenerative diseases
(via sciencedaily.com) Original source A team of researchers found that caffeic-acid based Carbon Quantum Dots (CACQDs), which can be derived from spent coffee grounds, have the potential to protect brain cells from the damage caused by several neurodegenerative diseases.
Published Putting an end to plastic separation anxiety
(via sciencedaily.com) Original source Bio-based plastics often end up in recycling streams because they look and feel like conventional plastic, but the contamination of these compostable products makes it much harder to generate functional material out of recycled plastic. Scientists have now developed a biology-driven process to convert these mixtures into a new biodegradable material that can be used to make fresh products. The scientists believe the process could also enable a new field of biomanufacturing wherein valuable chemicals and even medicines are made from microbes feeding off of plastic waste.