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Categories: Biology: Molecular, Chemistry: Organic Chemistry
Published Shedding light on unique conduction mechanisms in a new type of perovskite oxide
(via sciencedaily.com) Original source The remarkable proton and oxide-ion (dual-ion) conductivities of hexagonal perovskite-related oxide Ba7Nb3.8Mo1.2O20.1 are promising for next-generation electrochemical devices. The unique ion-transport mechanisms they unveiled will hopefully pave the way for better dual-ion conductors, which could play an essential role in tomorrow's clean energy technologies.
Published Heart repair via neuroimmune crosstalk
(via sciencedaily.com) Original source Unlike humans, zebrafish can completely regenerate their hearts after injury. They owe this ability to the interaction between their nervous and immune systems, as researchers now report.
Published New method to help with analysis of single cell data
(via sciencedaily.com) Original source CITE-seq (cellular indexing of transcriptomes and epitopes) is an RNA sequencing-based method that simultaneously quantifies cell surface protein and transcriptomic data within a single cell readout. The ability to study cells concurrently offers unprecedented insights into new cell types, disease states or other conditions. While CITE-seq solves the problem of detecting a limited number of proteins while using single-cell sequencing in an unbiased way, one of its limitations is the high levels of background noise that can hinder analysis.
Published Genomic tug of war could boost cancer therapy
(via sciencedaily.com) Original source Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat myelodysplastic syndromes that is plagued by drug resistance issues. For the first time, researchers show that decitabine causes coding and non-coding regions of DNA to engage in a tug of war for a gene activator, called H2A.Z. Typically, deticabine draws this gene activator away from coding DNA, causing gene expression to grind to a halt and cells to die. However, many types of cancer have very high levels of H2A.Z, which may help them overcome this decitabine-induced tug of war, allowing the cancer to grow.
Published How cell identity is preserved when cells divide
(via sciencedaily.com) Original source A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation. Within each cell's nucleus, researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.
Published Much more than waste: Tiny vesicles exchange genetic information between cells in the sea
(via sciencedaily.com) Original source Researchers take a look at data that has so far been mostly discarded as contamination, revealing the previously underestimated role of extracellular vesicles (EVs). These are important for the exchange of genetic information between cells and thus for the microbial community in the sea.
Published Pushing the boundaries of eco-friendly chemical production
(via sciencedaily.com) Original source A team of pioneering researchers has made a significant leap forward in the complex world of molecular chemistry. Their focus? Azaarenes, unique molecular puzzle pieces crucial to many everyday products, from eco-friendly agrochemicals to essential medicines. The team developed an innovative way to modify these molecules using light-powered enzymes -- a groundbreaking discovery that holds promise for new industrially relevant chemical reactions and sustainable energy solutions.
Published Hormones have the potential to treat liver fibrosis
(via sciencedaily.com) Original source Researchers have discovered previously unknown changes in a specific type of liver cells, potentially opening avenues for a new treatment for liver fibrosis, a potentially life-threatening condition. Currently, there are no drugs available to treat liver fibrosis.
Published How bacteria recognize viral invasion and activate immune defenses
(via sciencedaily.com) Original source Bacteria have an array of strategies to counter viral invasion, but how they first spot a stranger in their midst has long been a mystery.
Published Engineering bacteria to biosynthesize intricate protein complexes
(via sciencedaily.com) Original source Protein cages found in nature within microbes help weather its contents from the harsh intracellular environment -- an observation with many bioengineering applications. Researchers recently developed an innovative bioengineering approach using genetically modified bacteria; these bacteria can incorporate protein cages around protein crystals. This in-cell biosynthesis method efficiently produces highly customized protein complexes, which could find applications as advanced solid catalysts and functionalized nanomaterials.
Published Water splitting reaction for green hydrogen gas production improved
(via sciencedaily.com) Original source Electrochemical catalysts used in water splitting often show poor performance due to low electrical conductance of (oxy)hydroxide species produced in situ. To overcome this challenge, researchers have now designed an electrode with Schottky Junction formed at the interface of metallic Ni-W5N4 and semiconducting NiFeOOH. The proposed electrode shows excellent catalytic activity and can facilitate industrial seawater splitting continuously for 10 days.
Published Colliding ribosomes activate RNA repair
(via sciencedaily.com) Original source Researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage.
Published Novel C. diff structures are required for infection, offer new therapeutic targets
(via sciencedaily.com) Original source Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles.
Published A tale of two proteins: Fundamental research could make growing better crops like clockwork
(via sciencedaily.com) Original source Rhomboid-like protein 10, or RBL10, is thought to be an enzyme that degrades other proteins in the chloroplast membrane, but its function is largely unknown. Researchers are studying how RBL10 affects photosynthetic membrane lipid metabolism, an essential process in photosynthesis.
Published New discovery on how green algae count cell divisions illuminates key step needed for the evolution of multicellular life
(via sciencedaily.com) Original source An international research team has made an unexpected discovery of a biased counting mechanism used by the single-celled green alga Chlamydomonas to control cell division.
Published How marine bristle worms use a special protein to distinguish between sunlight and moonlight
(via sciencedaily.com) Original source A research team has presented its findings on the functioning of an atypical cryptochrome protein (Cry). These proteins are found in a variety of organisms, and they are often involved in light-controlled biological processes. The marine bristle worm Platynereis dumerilii, for example, employs a special Cry protein designated L-Cry to distinguish between sunlight and moonlight as well as between different moon phases. This is essential for the worms to synchronize their reproduction to the full moon phase via an inner monthly calendar, also called circalunar clock.
Published AI programs spat out known data and hardly learned specific chemical interactions when predicting drug potency
(via sciencedaily.com) Original source Artificial intelligence (AI) is on the rise. Until now, AI applications generally have 'black box' character: How AI arrives at its results remains hidden. A cheminformatics scientist has now developed a method that reveals how certain AI applications work in pharmaceutical research. The results are unexpected: the AI programs largely remembered known data and hardly learned specific chemical interactions when predicting drug potency.
Published Ground-breaking discovery could pave the way for new therapies to prevent cardiovascular disease and stroke
(via sciencedaily.com) Original source Researchers have discovered the mechanism by which cholesterol in our diet is absorbed into our cells. This discovery opens up new opportunities for therapeutic intervention to control cholesterol uptake that could complement other therapies and potentially save lives.
Published The Goldilocks Effect: Researchers establish framework for protein regulation
(via sciencedaily.com) Original source Researchers are working to understand how protein quality control works in cells.
Published New drug-like molecule extends lifespan, ameliorates pathology in worms and boosts function in mammalian muscle cells
(via sciencedaily.com) Original source Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process. Researchers have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells.