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Categories: Biology: Molecular, Chemistry: Organic Chemistry

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Researchers have identified a gene which is an early determining factor of ovary development in mice.

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An international team of researchers has discovered that formaldehyde, a widely spread pollutant and common metabolite in our body, interferes in the epigenetic programming of the cell. This finding expands the knowledge of formaldehyde, previously considered only as a DNA mutagen, and helps establishing a further link with cancer.

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Researchers found that the hormone oxytocin, known to be involved in regulating feeding and social behavior and until now to be produced mostly in the brain, is also produced in the human intestine. Furthermore, gut resident bacteria L. reuteri can affect the production of gut-made oxytocin, providing the first insights into a mechanism by which these bacteria can influence human health.

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In the immune system's fight against cancer and infections, the T cells often lose their power. Now immunologists may have found a possible explanation for this phenomenon.

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Biodegradable waste from plant and animal sources released into freshwater ecosystems is a significant environmental concern. Nonetheless, current methods for assessing water quality seem more or less impractical due to their complexity and high costs. In a promising development, a team of researchers has successfully constructed a self-sustaining and buoyant biosensor using inexpensive carbon-based materials for monitoring water quality at the inlets of freshwater lakes and rivers.

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Our understanding of how cells recycle lipids through autophagy -- a form of cellular degradation -- has grown significantly, thanks to a recent study. Using yeast as a model organism, the researchers explored the molecular mechanisms leading to the degradation of the phospholipid bilayers making up the cell membranes. Their findings improve our understanding of cellular degradation processes and related metabolic disorders.

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Chemists offer two new methods to develop a way to easily replace a carbon atom with a nitrogen atom in a molecule.  The findings could make it easier to develop new drugs.

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Researchers have genetically engineered the first mice that get a human-like form of COVID-19, according to a new study.

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The human heart, often described as the body's engine, is a remarkable organ that tirelessly beats to keep us alive. At the core of this vital organ, intricate processes occur when it contracts, where thick and thin protein-filaments interact within the sarcomere, the fundamental building block of both skeletal and heart muscle cells. Any alterations in thick filament proteins can have severe consequences for our health, leading to conditions such as hypertrophic cardiomyopathy and various other heart and muscle diseases.

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Many hidden genetic variations can be detected with Chameleolyser, a new method. The information is already yielding new patient diagnoses and may also lead to the discovery of as yet unknown disease genes.

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Mountains of used plastic bottles get thrown away every day, but microbes could potentially tackle this problem. Now, researchers report that they've developed a plastic-eating E. coli that can efficiently turn polyethylene terephthalate (PET) waste into adipic acid, which is used to make nylon materials, drugs and fragrances.

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Formic acid, which can be produced electrochemically from carbon dioxide, is a promising energy carrier. A research team has now developed a fast-charging hybrid battery system that combines the electrochemical generation of formic acid as an energy carrier with a microbial fuel cell. This novel, fast-charging biohybrid battery system can be used to monitor the toxicity of drinking water, just one of many potential future applications.

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Researchers have developed a device that can detect the presence of specific molecules in a sample every 20 nanoseconds, or billionths of a second. With this new capability, researchers can potentially use frequency combs to better understand the split-second intermediate steps in fast-moving processes ranging from the workings of hypersonic jet engines to the chemical reactions between enzymes that regulate cell growth.

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Engineers have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins. The surface of the nanoparticles is engineered to host any biological molecules of choice, making it possible to tailor the nanoparticles for a wide array of applications, ranging from targeted drug delivery to neutralizing biological agents.

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Researchers introduce the 'Telomouse'. By making a subtle genetic alteration in standard lab mice, they've made the mouse telomeres, which protect the chromosome ends, more closely resemble those in humans. The Telomouse model, developed by incorporating a genetic variation from a mouse species with naturally shorter telomeres, provides a valuable resource for in-depth aging and cancer research. This discovery promises to reveal new insights into the genetics of aging and may contribute to enhanced longevity and well-being.

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There are high hopes for hydrogen as the key to the energy transition. A specific enzyme group found in algae and in bacteria can produce molecular hydrogen simply by catalyzing protons and electrons. However, the enzyme group is so sensitive to oxygen that commercial use of the hydrogen produced by this process as a green energy source is not yet possible. Researchers have now increased the oxygen stability of a hydrogen-producing enzyme by genetically generated channel blockages.

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Cat hair could be the purr-fect way to catch criminals, according to researchers.

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Dendritic cells are immune cells that capture and present antigens to T cells, activating an immune response. Researchers have discovered that short-chain fatty acids produced by intestinal bacteria regulate a crucial step in this process, the extension of dendritic 'arms.' This breakthrough finding could potentially lead to the development of disease prevention strategies involving beneficial bacteria and new drugs targeting the regulation of dendritic cell function.

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Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.

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Researchers have discovered a protein that seals plant roots to regulate the uptake of nutrients and water from the soil, the discovery could help develop climate proof crops that require less water and chemical fertilizers.