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Categories: Biology: Molecular, Chemistry: Organic Chemistry

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Researchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.

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Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell. A study suggests that mammalian cells internalize phages as a resource to promote cellular growth and survival.

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Special proteins -- known as membrane transporters -- are key to the mobility of sperm cells. A research team has, with the aid of cryo-electron microscopy, succeeded in decoding the structure of such a transporter and its mechanism. These findings will enable a better understanding of the molecular foundations of reproductive capacity and could, in the long term, contribute to developing new approaches to treating fertility disorders and new methods of specific contraception.

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Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. This nanoscale device could represent a paradigm shift, harnessing power from ion gradients or electrical potential across a solid-state nanopore to drive the turbine into mechanical rotations. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore. By ingeniously designing two chiral turbines, researchers now have the capability to dictate the direction of rotation, clockwise or anticlockwise.

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A team of researchers has gained new insights into the respiratory system of fruit flies -- the so-called tracheal system -- which could be important for future research into aneurysms. Scientists carried out genetic, cell biological and biochemical studies on Drosophila embryos. They found that the cells in the fruit fly's tracheal system are connected to the extracellular matrix by the proteins Dumpy and Piopio.

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Eggs of the mosquito that carries Zika virus can tolerate extended desiccation by altering their metabolism, according to a new study. The finding offers potential new ways to control the spread of this mosquito.

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Researchers have solved the structure of a novel insecticidal protein that is effective in protecting major crop plants like corn and soybean from pests and is naturally produced by ferns.

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What if your house plant could tell you your water isn't safe? Scientists are closer to realizing this vision, having successfully engineered a plant to turn beet red in the presence of a banned, toxic pesticide. 

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A team of researchers has developed a software tool that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However, there are some challenges in the use of CRISPR. The new analysis system overcomes these challenges and allows researchers to perform safer on- and off-target assessments without a reference genome. It holds the potential for applications in medicine, agriculture, and biological research.

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Stimulating muscle fibers with magnets causes them to grow in the same direction, aligning muscle cells within tissue. The findings offer a simpler, less time-consuming way for medical researchers to program muscle cell alignment, which is strongly tied to healthy muscle function.

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The ability of Mycobacterium tuberculosis (MTB), a serious respiratory infection, to form snake-like cords was first noted nearly 80 years ago. Investigators report the biophysical mechanisms by which these cords form and demonstrate how several generations of dividing bacteria hang together to create these structures that enable resistance to antibiotics.

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Turning unused waste from food production into clean energy: Researchers are using chicken feathers to make fuel cells more cost-effective and sustainable.

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An international team of scientists has recently developed a novel type of nano engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines.

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Proteins are important molecules that perform a variety of functions essential to life. To function properly, many proteins must fold into specific structures. However, the way proteins fold into specific structures is still largely unknown. Researchers have developed a novel physical theory that can accurately predict how proteins fold. Their model can predict things previous models cannot. Improved knowledge of protein folding could offer huge benefits to medical research, as well as to various industrial processes.

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Yeast cells are widely used to study G protein-coupled receptors (GPCRs), a large group of cell surface proteins in humans. However, several of these proteins lose their function when introduced into yeast cells. To tackle this issue, researchers developed an innovative strategy to restore GPCR function in yeast cells by inducing random mutations. Their findings can help understand GPCRs better and could pave the way to therapeutic breakthroughs for many diseases.

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The development of tumors begins with miniscule changes within the body's cells; ion diffusion at the smallest scales is decisive in the performance of batteries. Until now the resolution of conventional imaging methods has not been high enough to represent these processes in detail. A research team has now developed diamond quantum sensors which can be used to improve resolution in magnetic imaging.

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New soft, implantable fibers can deliver light to major nerves through the body. They are an experimental tool for scientists to explore the causes and potential treatments for peripheral nerve disorders in animal models.

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A microscopic discovery will not only enable scientists to understand the microbial world around us but could also provide a new way to control CRISPR-Cas biotechnologies.

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A new study focuses on using computer algorithms to generate adaptations to molecules in compounds for existing and potential medications that can improve those molecules' ability to bind to the main protease, a protein-based enzyme that breaks down complex proteins, in SARS-CoV-2, the virus that causes COVID-19.

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A research group has developed a new method for studying how cancer cells function in softer and stiffer tissue environments. This insight challenges the existing paradigm, opening up new possibilities for research in cancer biology and tissue engineering.