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Categories: Biology: Molecular, Chemistry: Organic Chemistry

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A milliliter of blood contains about 15 individual drops. For a person with human immunodeficiency virus (HIV), each drop of blood could contain anywhere from fewer than 20 copies of the virus to more than 500,000 copies. Called the viral load, this is what is measured to allow clinicians to understand how patients are responding to anti-viral medications and monitor potential progression. The time-consuming viral load testing needs to be repeated several times as a patient undergoes treatment. Now, a research team has developed a time and cost-efficient digital assay that can directly measure the presence of HIV in single drop of blood.

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A water purification system separates out salt and other unnecessary particles with an electrified version of dialysis. Successfully applied to wastewater with planned expansion into rivers and seas, the method saves money and saps 90% less energy than its counterparts.

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Scientists detect a new carbon compound in space for the first time. Known as methyl cation (pronounced cat-eye-on) (CH3+), the molecule is important because it aids the formation of more complex carbon-based molecules. Methyl cation was detected in a young star system, with a protoplanetary disk, known as d203-506, which is located about 1,350 light-years away in the Orion Nebula.

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Just as space holds infinite mysteries, when we zoom in at the level of biomolecules (one trillion times smaller than a meter), there is still so much to learn. Scientists are studying the conformational landscapes of biomolecules and how they modulate cell function. When biomolecules receive certain inputs, it can cause the atoms to rearrange and the biomolecule to change shape. This change in shape affects their function in cells, so understanding conformational dynamics is critical for drug development.

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Researchers have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in protein sorting.

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An obscure aquatic plant has helped to explain how plants avoid cracking up under the stresses and strains of growth.

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To unveil the previously elusive behavior and stability of complex metal compounds found in aqueous solutions called 'POMs', researchers have created a speciation atlas. This achievement has the potential to drive new discoveries and advancements in fields like catalysis, medicine, and beyond.

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The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists.

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Engineers designed a technology to probe connections between the brain and the digestive tract. Using fibers embedded with a variety of sensors, as well as optogenetic stimulation, the researchers could control neural circuits connecting the gut and the brain, in mice.

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Scientists have built a new, comprehensive AutoML platform designed for biologists with little to no ML experience. New automated machine learning platform enables easy, all-in-one analysis, design, and interpretation of biological sequences with minimal coding. Their platform, called BioAutoMATED, can use sequences of nucleic acids, peptides, or glycans as input data, and its performance is comparable to other AutoML platforms while requiring minimal user input.

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DNA can mimic protein functions by folding into elaborate, three-dimensional structures, according to a new study.

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A gel that combines both stiffness and toughness is a step forward in the bid to create biodegradable implants for joint injuries, according to new research. Mimicking articular cartilage, found in our knee and hip joints, is challenging. This cartilage is key to smooth joint movement, and damage to it can cause pain, reduce function, and lead to arthritis. One potential solution is to implant artificial scaffolds made of proteins that help the cartilage regenerate itself as the scaffold biodegrades. How well the cartilage regenerates is linked to how well a scaffold can mimic the biological properties of cartilage, and to date, researchers have struggled to combine the seemingly incompatible properties of stiffness and toughness. Now, new research outlines a method to marry these properties in a biodegradable gel.

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Researchers have outlined the structure and function of a protein complex which is required to repair damaged DNA and protect against cancer.

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Collaborators have created 'living-like' bioactive interior architecture designed to one day protect us from hidden airborne threats. This publication establishes that the lab's biomaterial manufacturing process is compatible with the leading-edge cell-free engineering that gives the bioactive sites their life-like properties.

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Scientists have uncovered a new quality control system that removes damaged cells from early developing embryos.

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Researchers have used an unprecedented stem cell zoo to compare six different mammalian species and their developmental time.

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Researchers have demonstrated how carbon dioxide can be captured from industrial processes -- or even directly from the air -- and transformed into clean, sustainable fuels using just the energy from the Sun.

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Genome Architecture Mapping captures complex, multi-way interactions in the genome. This is different than the workhorse technique of 3D genomics, which sees mostly two-way contacts, finds a new study.

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Scientists discover shattered chromosomal fragments are tethered together during cell division before being rearranged; destroying the tether may help prevent cancerous mutations.

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A team or researchers reports the first Aging Fly Cell Atlas (AFCA), a detailed characterization of the aging process in 163 distinct cell types in the laboratory fruit fly. Their in-depth analysis revealed that different cell types in the body age differently, each cell type following a process involving cell type-specific patterns. AFCA provides a valuable resource for researchers in the fruit fly and aging communities as a reference to study aging and age-related diseases and to evaluate the success of anti-aging strategies.