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Categories: Biology: Molecular, Chemistry: Thermodynamics

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The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption and assimilation, as part of this system. A team found that stimulation and inhibition of the sweet receptor helps regulate glucose metabolism in humans and may have implications for managing such metabolic disorders as diabetes.

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A paper describes how the moving parts of a particular plant protein control whether plants can grow and make energy-intensive products such as oil -- or instead put in place a series of steps to conserve precious resources. The study focuses specifically on how the molecular machinery is regulated by a molecule that rises and falls with the level of sugar -- plants' main energy source.

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Plants have special corrective molecules at their disposal that can make retrospective modifications to copies of genes. However, it would appear that these 'Tipp-Ex proteins' do not have permission to work in all areas of the cell, only being used in chloroplasts and mitochondria. A study has now explained why this is the case. It suggests that the correction mechanism would otherwise modify copies that have nothing wrong with them, with fatal consequences for the cell.

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If fruit fly wings do not develop into the right shape, the flies will die. Researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments for birth defects.

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Thermoelectric materials could play an important role in the clean energy transition, as they can produce electricity from sources of heat that would otherwise go to waste. Researchers report a new approach to efficiently predict when thermoelectric materials will have improved performance in converting heat into electricity.

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A molecular biologist may have found a new 'rule of biology.' The rule challenges long-held notions that most living organisms prefer stability over instability because stability requires less energy and fewer resources.

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A new sensor is giving researchers the best look yet at ATP levels inside living cells, enabling scientists to study in greater detail than ever before how fluctuations in this cellular currency affect the cell and contribute to disease.

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Vanilla, the most widely used flavoring compound in confectionaries and cosmetics, gets its sweet flavor and aroma from the chemical compound -- 'vanillin'. However, the large-scale production of natural vanillin is impeded by the lack of microbial processes and enzymes which can commercially generate vanillin. Now, researchers have genetically engineered a novel enzyme which can convert ferulic acid from plant waste into vanillin in a one-step sustainable process.

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Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications. The findings could revolutionize wide swathes of biology by fundamentally changing how protein structure is studied and leveraged for drug design.

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Researchers have developed a new method that can lead to significant energy savings in buildings. The team identified 28 major heat loss regions in a multi-unit residential building with the most severe ones being at wall intersections and around windows. A potential energy savings of 25 per cent is expected if 70 per cent of the discovered regions are fixed.

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A biological mechanism familiar to people who fast helps plant roots grow strong. The discovery provides an answer to a long-unanswered question and a deeper understanding of the 'mouths' of plants that can help to develop climate-resilient crops.

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At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one. A team may have found what they're looking for. The researchers showed that the compound K11777 prevents host cells from helping the virus out of its shell by cleaving the viral capsid. This means it can no longer infect cells.

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Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used genetically engineered mice to demonstrate the role of HLA in mediating intracellular reactions in keratinocytes, leading to drug eruptions in the skin. Their findings could lead to improved preventive and treatment measures for drug eruptions.

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Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins. Prion disease is an umbrella term for a group of fatal and currently untreatable neurodegenerative diseases that not only affect humans, but also wild and captive animals. These diseases include Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE, or 'mad cow disease'), and chronic wasting disease (CWD) affecting deer, elk and moose.

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What makes the oldfield mouse steadfastly monogamous throughout its life while its closest rodent relatives are promiscuous? The answer may be a previously unknown hormone-generating cell. Scientists discover the cells and hormones that inspire mice to nurture their young; the same hormones are also present in humans.

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Instead of burning fossil fuels to smelt steel and cook cement, researchers in Switzerland want to use heat from the sun. The proof-of-concept study uses synthetic quartz to trap solar energy at temperatures over 1,000 C (1,832 F), demonstrating the method's potential role in providing clean energy for carbon-intensive industries.

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Scientists have documented the benefits of lactate burning in exercising humans, but few studies have looked at the role of lactate during rest or after a meal. Exercise physiologists challenged fasting men and women with a carbohydrate meal and then monitored lactate in the blood and fat vs carbohydrate metabolism. They found that lactate buffers glucose from a meal, and that lactate is utilized for energy almost as much as glucose.

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Researchers are using artificial intelligence to perfect the design of the vessels surrounding the super-hot plasma, optimize heating methods and maintain stable control of the reaction for increasingly long periods. A new article explains how a researcher team used machine learning to avoid magnetic perturbations, or disruptions, which destabilize fusion plasma.

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A research team has unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve.

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A way to curb nagging insects has been flying under our radar -- an enzyme from fruit fly testes. The compound could control bugs that carry disease and harm crops by stunting their ability to procreate, researchers have found.