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Categories: Biology: Molecular, Chemistry: Thermodynamics

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Multidrug-resistant bacterial infections that cannot be treated by any known antibiotics pose a serious global threat. A research team has now introduced a method for the development of novel antibiotics to fight resistant pathogens. The drugs are based on protein building blocks with fluorous lipid chains.

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Research groups have made a breakthrough in the field of hard disk drives (HDD) by demonstrating the feasibility of multi-level recording using a three-dimensional magnetic recording medium to store digital information. The research groups have shown that this technology can be used to increase the storage capacity of HDDs, which could lead to more efficient and cost-effective data storage solutions in the future.

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Researchers developed a foundational language model to decode mRNA sequences and optimize those sequences for vaccine development. The tool shows broader promise as a means for studying molecular biology.

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Biophysicists have demonstrated how heat flows through rock fissures could have created the conditions for the emergence of life.

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Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions. The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that are found to be involved in disease such as cancer.

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A new study finds that UCYN-A, a species of nitrogen-fixing cyanobacteria, may be evolving organelle-like characteristics.

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A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study reveals the role of a sugar called sialic acid in this invasion process. The findings have major implications for malaria vaccine and drug development.

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A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. Although centromeres are vital to proper cell replication by assuring faithful transmision of genetic materials when cells divide, the complexity of their genomic organization had been almost impossible to study. The lack of centromere sequences hindered exploration of how these regions help maintain genetic integrity. Now, advanced technologies have shown scientists how greatly centromeres differ in size and structure.

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There is room for just one small bottle in the world's first refrigerator that is cooled with artificial muscles made of nitinol, a nickel-titanium alloy. But the mini-prototype is groundbreaking: it shows that elastocalorics is becoming a viable solution for practical applications. This climate-friendly cooling and heating technology is far more energy-efficient and sustainable than current methods.

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Windows welcome light into interior spaces, but they also bring in unwanted heat. A new window coating blocks heat-generating ultraviolet and infrared light and lets through visible light, regardless of the sun's angle. The coating can be incorporated onto existing windows or automobiles and can reduce air-conditioning cooling costs by more than one-third in hot climates.

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Researchers have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are an important step in the development of drugs against the deadly disease.

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Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.

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Biologists have uncovered a quality control timing mechanism tied to cell division. The 'stopwatch' function keeps track of mitosis and acts as a protective measure when the process takes too long, preventing the formation of cancerous cells.

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Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.

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Understanding the structure of proteins is critical for demystifying their functions and developing drugs that target them. To that end, a team of researchers has developed a way of using machine learning to rapidly predict multiple protein configurations to advance understanding of protein dynamics and functions.

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Conditions that usually accompany the kind of intense hot and cold weather that strains power grids may also provide greater opportunities to capture solar and wind energy. A study found that widespread, extreme temperature events are often accompanied by greater solar radiation and higher wind speeds that could be captured by solar panels and wind turbines. The research, which looked at extensive heat and cold waves across the six interconnected energy grid regions of the U.S. from 1980-2021, also found that every region experienced power outages during these events in the past decade. The findings suggest that using more renewable energy at these times could help offset increased power demand as more people and businesses turn on heaters or air conditioners.

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Tardigrade proteins are potential candidates in technologies centered on slowing the aging process and in long-term storage of human cells.

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Entropy, the amount of molecular disorder, is produced in several systems but cannot be measured directly. A new equation sheds new light on how entropy is produced on a very short time scale in laser excited materials.

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Scientists have uncovered a unique mechanism that regulates the opening of stomata in plants. Phosphorylation of the amino acid Thr881 on the plasma membrane proton pump plays a key role in this process. The study paves the way for the targeted manipulation of plant physiology, with potential applications in agriculture and environmental sustainability.

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A real-world study has shown that the use of cool paint coatings in cities can help pedestrians feel up to 1.5 degrees Celsius cooler, making the urban area more comfortable for work and play.