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Categories: Biology: Molecular, Energy: Alternative Fuels

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CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy.

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Research achieves scientific breakthrough in understanding cell division.

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Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the immune system. For analysis of the necessary complex antigen processing and transport processes in real time, researchers have developed a 'cage' that is opened with light to release trapped antigens at a specific place and time.

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This new concept could allow the needs of previously separate industries to be combined: the production of hydrogen and the production of fertilizer.

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Scientists have successfully created mechanical force sensors directly in the developing brains and spinal cords of chicken embryos, which they hope will improve understanding and prevention of birth malformations such as spina bifida.

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RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste. Researchers report a new, enzyme-based RNA synthesis method that can produce strands of RNA with both natural and modified nucleotides without the environmental hazards.

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The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study.

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Researchers have made significant inroads in understanding how nanoplastics and per- and polyfluoroalkyl substances (PFAS) -- commonly known as forever chemicals -- disrupt biomolecular structure and function. The work shows that the compounds can alter proteins found in human breast milk and infant formulas -- potentially causing developmental issues downstream.

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The possibility of hydrogen-powered flight means greater opportunities for fossil-free travel, and the technological advances to make this happen are moving fast. New studies show that almost all air travel within a 750-mile radius (1200 km) could be made with hydrogen-powered aircraft by 2045, and with a novel heat exchanger currently in development, this range could be even further.

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International joint research led by Akihisa Osakabe and Yoshimasa Takizawa of the University of Tokyo has clarified the molecular mechanisms in thale cresses (Arabidopsis thaliana) by which the DDM1 (Decreased in DNA Methylation 1) protein prevents the transcription of 'jumping genes.' DDM1 makes 'jumping genes' more accessible for transcription-suppressing chemical marks to be deposited. Because a variant of this protein exists in humans, the discovery provides insight into genetic conditions caused by such 'jumping gene' mutations.

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An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample. The fossilized chromosomes, which are around a million times longer than most ancient DNA fragments, provide insight into how the mammoth's genome was organized within its living cells and which genes were active within the skin tissue from which the DNA was extracted. This unprecedented level of structural detail was retained because the mammoth underwent freeze-drying shortly after it died, which meant that its DNA was preserved in a glass-like state.

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Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design.

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An unexpected find has enabled important progress to be made in the battle against harmful bacteria.

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Researchers discovered a microscopic mechanism that solves in part the outstanding performance achieved by a new class of organic semiconductors known as non-fullerene acceptors (NFAs).

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Experience from the deployment of blue hydrogen projects will be helpful in lowering future costs of hydrogen production and will remain cost competitive. Additionally, paired with extended tax incentives for carbon sequestration, costs could be significantly reduced further.

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A team of scientists have developed a new method that enables them to make precise edits in multiple locations within a cell -- all at once. Using molecules called retrons, they created a tool that can efficiently modify DNA in bacteria, yeast, and human cells.

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Researchers have developed a bioelectric device that can detect and classify new variants of coronavirus to identify those that are most harmful. It has the potential to do the same with other viruses, as well.

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Researchers have identified hexagonal perovskite-related oxides as materials with exceptionally high proton conductivity and thermal stability. Their unique crystal structure and large number of oxygen vacancies enable full hydration and high proton diffusion, making these materials ideal candidates as electrolytes for next-generation protonic ceramic fuel cells that can operate at intermediate temperatures without degradation.

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Researchers have developed a discovery platform to probe the function of genes involved in metabolism -- the sum of all life-sustaining chemical reactions. The investigators used the new platform, called GeneMAP (Gene-Metabolite Association Prediction), to identify a gene necessary for mitochondrial choline transport.

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Painting roofs white or covering them with a reflective coating would be more effective at cooling cities like London than vegetation-covered 'green roofs,' street-level vegetation or solar panels, finds a new study led by UCL researchers.