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Categories: Biology: Molecular, Energy: Nuclear
Published With inspiration from 'Tetris,' researchers develop a better radiation detector
(via sciencedaily.com) Original source A new detector system based on the game 'Tetris' could enable inexpensive, accurate radiation detectors for monitoring nuclear sites.
Published Genetic underpinnings of environmental stress identified in model plant
(via sciencedaily.com) Original source Researchers have identified 14 genes that thale cress -- a plant commonly used in genetic investigations since its genome is well documented -- express more when responding to five specific stressors, as well as eight genes that the plant suppresses.
Published The genesis of our cellular skeleton, image by image
(via sciencedaily.com) Original source Cells contain various specialized structures -- such as the nucleus, mitochondria or peroxisomes -- known as 'organelles'. Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction.
Published Researchers discover how we perceive bitter taste
(via sciencedaily.com) Original source A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.
Published A new coating method in mRNA engineering points the way to advanced therapies
(via sciencedaily.com) Original source Researchers have developed a novel method of adding polyethylene glycol molecules to engineered groups of messenger RNAs called 'mRNA polyplexes', which enable the cells that receive them to produce specific proteins. This technique allows greater control of the site in the body to which the polyplexes are delivered, significantly advancing the field of therapeutic mRNA technologies, with applications in vaccine development and the treatment of cancer and other diseases.
Published Cockayne syndrome: New insights into cellular DNA repair mechanism
(via sciencedaily.com) Original source Researchers decode repair mechanism during transcription of genetic information.
Published Machine learning method reveals chromosome locations in individual cell nucleus
(via sciencedaily.com) Original source Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene expression and disease processes.
Published Different means to the same end: How a worm protects its chromosomes
(via sciencedaily.com) Original source Researchers have discovered that a worm commonly used in the study of biology uses a set of proteins unlike those seen in other studied organisms to protect the ends of its DNA.
Published Bringing multidrug-resistant pathogens to their knees
(via sciencedaily.com) Original source Multidrug-resistant bacterial infections that cannot be treated by any known antibiotics pose a serious global threat. A research team has now introduced a method for the development of novel antibiotics to fight resistant pathogens. The drugs are based on protein building blocks with fluorous lipid chains.
Published Can language models read the genome? This one decoded mRNA to make better vaccines
(via sciencedaily.com) Original source Researchers developed a foundational language model to decode mRNA sequences and optimize those sequences for vaccine development. The tool shows broader promise as a means for studying molecular biology.
Published Heat flows the secret to order in prebiotic molecular kitchen
(via sciencedaily.com) Original source Biophysicists have demonstrated how heat flows through rock fissures could have created the conditions for the emergence of life.
Published New tools reveal how genes work and cells organize
(via sciencedaily.com) Original source Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these protein-RNA interactions. The newfound ability to predict these interactions can help future work in understanding molecular pathways in the cell and pave the way for developing drugs targeting these RNA G-quadruplex binding proteins, that are found to be involved in disease such as cancer.
Published Evolution in action? New study finds possibility of nitrogen-fixing organelles
(via sciencedaily.com) Original source A new study finds that UCYN-A, a species of nitrogen-fixing cyanobacteria, may be evolving organelle-like characteristics.
Published Researchers discover 'neutronic molecules'
(via sciencedaily.com) Original source Researchers have discovered 'neutronic' molecules, in which neutrons can be made to cling to quantum dots, held just by the strong force. The finding may lead to new tools for probing material properties at the quantum level and exploring new kinds of quantum information processing devices.
Published New discovery unravels malaria invasion mechanism
(via sciencedaily.com) Original source A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study reveals the role of a sugar called sialic acid in this invasion process. The findings have major implications for malaria vaccine and drug development.
Published First view of centromere variation and evolution
(via sciencedaily.com) Original source A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. Although centromeres are vital to proper cell replication by assuring faithful transmision of genetic materials when cells divide, the complexity of their genomic organization had been almost impossible to study. The lack of centromere sequences hindered exploration of how these regions help maintain genetic integrity. Now, advanced technologies have shown scientists how greatly centromeres differ in size and structure.
Published How the Crimean-Congo hemorrhagic fever virus enters our cells
(via sciencedaily.com) Original source Researchers have identified how the tick-borne Crimean-Congo haemorrhagic fever virus enters our cells. The results are an important step in the development of drugs against the deadly disease.
Published Researchers discover key gene for toxic alkaloid in barley
(via sciencedaily.com) Original source Barley is one of the most important cereal crops on a global scale. Many barley cultivars produce a toxic alkaloid called gramine that affects the suitability of barley as fodder, but also helps to protect barley from pathogens. So far, the potential of manipulating gramine levels has not been harnessed for plant breeding, because the genetic basis of gramine production has been unresolved. Research groups now disclose the complete biosynthetic pathway of gramine and demonstrate how gramine biosynthesis can be introduced into model organisms or removed from barley.
Published Cell division quality control 'stopwatch' uncovered
(via sciencedaily.com) Original source Biologists have uncovered a quality control timing mechanism tied to cell division. The 'stopwatch' function keeps track of mitosis and acts as a protective measure when the process takes too long, preventing the formation of cancerous cells.
Published Connecting the dots to shape growth forces
(via sciencedaily.com) Original source Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence the development of the lungs' complex branches. Researchers have unveiled a regulatory system linking signal, force, and shape in mouse lung structure development. The team recognized that the signal protein ERK plays an active role in causing growing lung tissue to curve.