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Categories: Biology: Molecular, Energy: Nuclear
Published Visualizing fungal infections deep in living host tissue reveals proline metabolism facilitates virulence
(via sciencedaily.com) Original source Scientists have published the first successful application of 2-photon intravital microscopy (IVM) to image the dynamics of fungal infections in the kidney of a living host. The study reveals that the opportunistic human fungal pathogen Candida albicans requires the ability to metabolize proline, an amino acid obtained from the host, to mount virulent infections.
Published Female sex determining gene identified in mice
(via sciencedaily.com) Original source Researchers have identified a gene which is an early determining factor of ovary development in mice.
Published A known environmental hazard can change the epigenetics of cells
(via sciencedaily.com) Original source An international team of researchers has discovered that formaldehyde, a widely spread pollutant and common metabolite in our body, interferes in the epigenetic programming of the cell. This finding expands the knowledge of formaldehyde, previously considered only as a DNA mutagen, and helps establishing a further link with cancer.
Published Research connecting gut bacteria and oxytocin provides a new mechanism for microbiome-promoted health benefits
(via sciencedaily.com) Original source Researchers found that the hormone oxytocin, known to be involved in regulating feeding and social behavior and until now to be produced mostly in the brain, is also produced in the human intestine. Furthermore, gut resident bacteria L. reuteri can affect the production of gut-made oxytocin, providing the first insights into a mechanism by which these bacteria can influence human health.
Published Immunology: Dysfunction of mitochondria drives the exhaustion of T cells
(via sciencedaily.com) Original source In the immune system's fight against cancer and infections, the T cells often lose their power. Now immunologists may have found a possible explanation for this phenomenon.
Published New study sheds light on the molecular mechanisms underlying lipid recycling within cells
(via sciencedaily.com) Original source Our understanding of how cells recycle lipids through autophagy -- a form of cellular degradation -- has grown significantly, thanks to a recent study. Using yeast as a model organism, the researchers explored the molecular mechanisms leading to the degradation of the phospholipid bilayers making up the cell membranes. Their findings improve our understanding of cellular degradation processes and related metabolic disorders.
Published First mice engineered to survive COVID-19 like young, healthy humans
(via sciencedaily.com) Original source Researchers have genetically engineered the first mice that get a human-like form of COVID-19, according to a new study.
Published Plastic-eating bacteria turn waste into useful starting materials for other products
(via sciencedaily.com) Original source Mountains of used plastic bottles get thrown away every day, but microbes could potentially tackle this problem. Now, researchers report that they've developed a plastic-eating E. coli that can efficiently turn polyethylene terephthalate (PET) waste into adipic acid, which is used to make nylon materials, drugs and fragrances.
Published Scientists create special 'telomouse' with human-like telomeres
(via sciencedaily.com) Original source Researchers introduce the 'Telomouse'. By making a subtle genetic alteration in standard lab mice, they've made the mouse telomeres, which protect the chromosome ends, more closely resemble those in humans. The Telomouse model, developed by incorporating a genetic variation from a mouse species with naturally shorter telomeres, provides a valuable resource for in-depth aging and cancer research. This discovery promises to reveal new insights into the genetics of aging and may contribute to enhanced longevity and well-being.
Published Monitoring nuclear weapons stockpiles with radio waves
(via sciencedaily.com) Original source Monitoring whether states are complying with disarmament treaties is not an easy task. An international team has been exploring remote monitoring with the help of two antennas and a couple of mirrors.
Published Intestinal bacteria metabolite promotes capture of antigens by dendritic cells
(via sciencedaily.com) Original source Dendritic cells are immune cells that capture and present antigens to T cells, activating an immune response. Researchers have discovered that short-chain fatty acids produced by intestinal bacteria regulate a crucial step in this process, the extension of dendritic 'arms.' This breakthrough finding could potentially lead to the development of disease prevention strategies involving beneficial bacteria and new drugs targeting the regulation of dendritic cell function.
Published Controlling organoids with light
(via sciencedaily.com) Original source Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.
Published Protein root discovery seals future of climate-proof plants
(via sciencedaily.com) Original source Researchers have discovered a protein that seals plant roots to regulate the uptake of nutrients and water from the soil, the discovery could help develop climate proof crops that require less water and chemical fertilizers.
Published Researchers solve protein mystery
(via sciencedaily.com) Original source Researchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.
Published Mammalian cells may consume bacteria-killing viruses to promote cellular health
(via sciencedaily.com) Original source Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell. A study suggests that mammalian cells internalize phages as a resource to promote cellular growth and survival.
Published Membrane transporter ensures mobility of sperm cells
(via sciencedaily.com) Original source Special proteins -- known as membrane transporters -- are key to the mobility of sperm cells. A research team has, with the aid of cryo-electron microscopy, succeeded in decoding the structure of such a transporter and its mechanism. These findings will enable a better understanding of the molecular foundations of reproductive capacity and could, in the long term, contribute to developing new approaches to treating fertility disorders and new methods of specific contraception.
Published Defect in fruit fly respiratory system may provide insights into human aortic aneurysms
(via sciencedaily.com) Original source A team of researchers has gained new insights into the respiratory system of fruit flies -- the so-called tracheal system -- which could be important for future research into aneurysms. Scientists carried out genetic, cell biological and biochemical studies on Drosophila embryos. They found that the cells in the fruit fly's tracheal system are connected to the extracellular matrix by the proteins Dumpy and Piopio.
Published How eggs of the Zika-carrying mosquito survive desiccation
(via sciencedaily.com) Original source Eggs of the mosquito that carries Zika virus can tolerate extended desiccation by altering their metabolism, according to a new study. The finding offers potential new ways to control the spread of this mosquito.
Published Discovery finds ferns produce crop-saving insecticide
(via sciencedaily.com) Original source Researchers have solved the structure of a novel insecticidal protein that is effective in protecting major crop plants like corn and soybean from pests and is naturally produced by ferns.
Published Plants transformed into detectors of dangerous chemicals
(via sciencedaily.com) Original source What if your house plant could tell you your water isn't safe? Scientists are closer to realizing this vision, having successfully engineered a plant to turn beet red in the presence of a banned, toxic pesticide.