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Categories: Biology: Molecular, Energy: Nuclear

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The skeleton, tendons, and glands of a functional jaw all derive from the same population of stem cells, which arise from a cell population known as neural crest. To discover how these neural crest-derived cells know to make the right type of cell in the right location, researchers focused on a particular gene, Nr5a2, that was active in a region of the face that makes tendons and glands, but not skeleton. To understand the role of Nr5a2, the scientists created zebrafish lacking this gene. These mutant zebrafish generated excess cartilage and were missing tendons in their jaws.

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Strong electric fields can be used to create pores in biomembranes. The method is known as electroporation. Inducing such defects in membranes in a targeted manner is an important technique in medicine and biotechnology, but also in the treatment of foodstuffs.

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Most cells in the bodies of living things duplicate their contents and physically separate into new cells through the process of cell division. But across many species, germ cells, those that become eggs or sperm, don't fully separate. They remain interconnected through small bridges called ring canals and cluster together. In a new study, researchers uncover how it is that germ cells in fruit flies form these ring canals, a finding that they say will provide new insights into a widely shared feature of development and into diseases in which cell division is disrupted.

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A new analysis supports the idea that photons colliding with heavy ions create a fluid of 'strongly interacting' particles. The results indicate that photon-heavy ion collisions can create a strongly interacting fluid that responds to the initial collision geometry and that these collisions can form a quark-gluon plasma. These findings will help guide future experiments at the planned Electron-Ion Collider.

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New methodology and tools provide an opportunity to watch in unprecedented detail as a phage attacks a bacterium.

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Obese fruit flies are the experimental subjects in a study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels.

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Once upon a time, prevailing scientific opinion might have pronounced recently published research as unneeded. Now, climate change implications have heightened the need for this line of research. Flowers emit scent chemicals called volatile organic compounds (VOCs). Earlier this year, a study identified a protein that plays a key role in helping petunias emit volatiles.

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An international team of bee researchers has integrated a calcium sensor into honey bees to enable the study of neural information processing including response to odors. This also provides insights into how social behavior is located in the brain.

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In early cytological studies chromatids of metaphase chromosomes were suggested to coil into a spiral called chromonema. This assumption was recently supported by chromosomce conformation capture sequencing. Still, the direct visualization of the coiled chromonema confirming the helical model was lacking. Now, an international research team provides the direct proof of the helical coiling of condensed chromatids via super-resolution microscopy of specifically labelled chromonema regions.

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Scientists recently developed an efficient way to transplant pancreatic islets and demonstrated that the method can effectively reverse type 1 diabetes in nonhuman primates.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.

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A detailed atlas of gene expression in the zebrafish brain.

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Biochemists have succeeded in resurrecting the ancestral genes of five detoxifying enzymes which are present in all tetrapods to show how their divergence in function has occurred.

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By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today -- including plants, animals, and humans.

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Physicists report new evidence that production of an exotic state of matter in collisions of gold nuclei at the Relativistic Heavy Ion Collider (RHIC) can be 'turned off' by lowering the collision energy. The findings will help physicists map out the conditions of temperature and density under which the exotic matter, known as a quark-gluon plasma (QGP), can exist and identify key features of the phases of nuclear matter.

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Textbooks will tell you that in dividing cells, production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level. Molecular biologists have now discovered that this is not true: protein synthesis shows two peaks and lipid synthesis peaks once.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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Influenza viruses are becoming increasingly resilient to medicines. For this reason, new active ingredients are needed. Important findings in this regard have been provided: for the virus to proliferate, the polymerase of the influenza A virus has to be modified many times through enzymes in the host cells. The team of researchers was able to produce a comprehensive map of types of modification. Medicines directed against the enzymes woud be resilient to rapid mutations in the virus, thus offering great potential for the future.

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A team has developed a method for selectively manipulating genetically engineered cells with ultrasound.

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It started with a mystery: How did molten salt breach its metal container? Understanding the behavior of molten salt, a proposed coolant for next-generation nuclear reactors and fusion power, is a question of critical safety for advanced energy production. The multi-institutional research team, co-led by Penn State, initially imaged a cross-section of the sealed container, finding no clear pathway for the salt appearing on the outside. The researchers then used electron tomography, a 3D imaging technique, to reveal the tiniest of connected passages linking two sides of the solid container. That finding only led to more questions for the team investigating the strange phenomenon.