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Categories: Biology: Molecular, Engineering: Biometric
Published Mutation solves a century-old mystery in meiosis
(via sciencedaily.com) Original source A team deciphers complicated mechanism underlying genetic diversity.
Published Researchers develop artificial building blocks of life
(via sciencedaily.com) Original source For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.
Published Vitamin A may play a central role in stem cell biology and wound repair
(via sciencedaily.com) Original source Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.
Published The Malaria parasite generates genetic diversity using an evolutionary 'copy-paste' tactic
(via sciencedaily.com) Original source All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.
Published Cracking epigenetic inheritance: Biologists discovered the secrets of how gene traits are passed on
(via sciencedaily.com) Original source A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity.
Published First heat map for individual red blood cells
(via sciencedaily.com) Original source Entropy is often associated with disorder and chaos, but in biology it is related to energy efficiency and is closely linked to metabolism, the set of chemical reactions that sustain life. An international research team has now developed a novel methodology for the measurement of entropy production at the scale of a nanometer, meaning one-billionth of a meter. The new approach enabled the scientists to measure the heat flow, known as the entropy production rate, of single red blood cells.
Published Universal tool for tracking cell-to-cell interactions
(via sciencedaily.com) Original source An updated method for directly observing physical interactions between cells, could allow scientists to one day map every possible cell interaction.
Published Synthetic gene helps explain the mysteries of transcription across species
(via sciencedaily.com) Original source 'Random DNA' is naturally active in the one-celled fungi yeast, while such DNA is turned off as its natural state in mammalian cells, despite their having a common ancestor a billion years ago and the same basic molecular machinery, a new study finds.
Published Decoding the language of epigenetic modifications
(via sciencedaily.com) Original source Epigenetic changes play important roles in cancer, metabolic and aging-related diseases, but also during loss of resilience as they cause the genetic material to be incorrectly interpreted in affected cells. A major study now provides important new insights into how complex epigenetic modification signatures regulate the genome. This study will pave the way for new treatments of diseases caused by faulty epigenetic machineries.
Published Deconstructing the structural elements of a lesser-known microbe
(via sciencedaily.com) Original source Researchers shed light on archaea, intriguing microbes found in extreme environments but also in the human gut microbiome.
Published Microalgae with unusual cell biology
(via sciencedaily.com) Original source A globally distributed single-celled organism that occurs in harmful algal blooms has been found to exhibit an unusual organisation of photosynthesis. Researchers have taken a closer look at the unusual cell biology of the species Prorocentrum cordatum from the group of dinoflagellates. The results of their study could help to better understand the role of the species in the environment and the increased occurrence of algal blooms at higher water temperatures.
Published Modeling the origins of life: New evidence for an 'RNA World'
(via sciencedaily.com) Original source Scientists provide fresh insights on the origins of life, presenting compelling evidence supporting the 'RNA World' hypothesis. The study unveils an RNA enzyme that can make accurate copies of other functional RNA strands, while also allowing new variants of the molecule to emerge over time. These remarkable capabilities suggest the earliest forms of evolution may have occurred on a molecular scale in RNA, and also bring scientists one step closer to re-creating autonomous RNA-based life in the laboratory.
Published Photosynthetic secrets come to light
(via sciencedaily.com) Original source Secrets of photosynthesis have been discovered at atomic level, shedding important new light on this plant super-power that greened the earth more than a billion years ago.
Published Convergent evolution of algal CO2-fixing organelles
(via sciencedaily.com) Original source Researchers identified the proteins of a CO2-fixing organelle, namely, 'pyrenoid,' in the marine algal group Chlorarachniophyta and revealed various pyrenoid-associated proteins among algal groups, suggesting the independent evolution of pyrenoids in different algal groups.
Published Light into the darkness of photosynthesis
(via sciencedaily.com) Original source Researchers succeed at generating 3D visualizations of chloroplasts' copying machines.
Published How virus causes cancer: Potential treatment
(via sciencedaily.com) Original source Researchers have discovered a key mechanism used by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi's sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease.
Published New role for bacterial enzyme in gut metabolism revealed
(via sciencedaily.com) Original source Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat. They also are modified extensively by bacteria, which greatly expand the types of bile acids found in the host. For most of a century, scientists believed that was the end of the bile-acid story. Recent technological advances, however, have led to a greater understanding of the origins of bile acids as well as their chemical relationships to the organisms in the gut microbiome and their host.
Published Scientists identify new 'regulatory' function of learning and memory gene common to all mammalian brain cells
(via sciencedaily.com) Original source Neuroscientists say they have found a new function for the SYNGAP1 gene, a DNA sequence that controls memory and learning in mammals, including mice and humans.
Published Scientists develop novel RNA- or DNA-based substances to protect plants from viruses
(via sciencedaily.com) Original source Individually tailored RNA or DNA-based molecules are able to reliably fight off viral infections in plants, according to a new study. The researchers were able to fend off a common virus using the new active substances in up to 90 per cent of cases. They also developed a method for finding substances tailored specifically to the virus. The team has now patented the method.
Published The Golgi organelle's ribbon structure is not exclusive to vertebrates, contrary to previous consensus
(via sciencedaily.com) Original source Researchers report that the Golgi ribbon, an organelle structure previously thought to be exclusive to vertebrates, is also present in animal taxa, including mollusks, earthworms, and sea urchins. The function of the Golgi ribbon is still enigmatic, but its presence in diverse animal lineages indicates that its function is not vertebrate specific, as previously thought. The team also showed Golgi ribbons form at a specific timepoint during embryogenesis, which suggests that they might play a role in cell differentiation.