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Categories: Biology: Molecular, Engineering: Graphene
Published Scientists one step closer to re-writing world's first synthetic yeast genome, unravelling the fundamental building blocks of life
(via sciencedaily.com) Original source Scientists have engineered a chromosome entirely from scratch that will contribute to the production of the world's first synthetic yeast.
Published Scientists take major step towards completing the world's first synthetic yeast
(via sciencedaily.com) Original source A team of Scientists has completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome. The work represents completion of one of the 16 chromosomes of the yeast genome, which is part of the biggest project ever in synthetic biology; the international synthetic yeast genome collaboration. The collaboration, known as 'Sc2.0' has been a 15-year project involving teams from around the world (UK, US, China, Singapore, UK, France and Australia), working together to make synthetic versions of all of yeast's chromosomes. Alongside this paper, another 9 publications are also released today from other teams describing their synthetic chromosomes. The final completion of the genome project -- the largest synthetic genome ever -- is expected next year.
Published Obesity linked to neurodegeneration through insulin resistance
(via sciencedaily.com) Original source Researchers have discovered a link between obesity and neurodegenerative disorders like Alzheimer's disease. Using the common fruit fly, the research shows that a high-sugar diet -- a hallmark of obesity -- causes insulin resistance in the brain, which in turn reduces the ability to remove neuronal debris, thus increasing the risk of neurodegeneration.
Published Some benefits of exercise stem from the immune system
(via sciencedaily.com) Original source Research in mice shows that the anti-inflammatory properties of exercise may arise from immune cells mobilized to counter exercise-induced inflammation. Immune cells prevent muscle damage by lowering levels of interferon, a key driver of chronic inflammation, inflammatory diseases, and aging.
Published New antibiotic approach proves promising against lyme bacterium
(via sciencedaily.com) Original source Using a technique that has shown promise in targeting cancer tumors, a team has found a way to deploy a molecular warhead that can annihilate the bacterium that causes Lyme disease.
Published Visualizing fungal infections deep in living host tissue reveals proline metabolism facilitates virulence
(via sciencedaily.com) Original source Scientists have published the first successful application of 2-photon intravital microscopy (IVM) to image the dynamics of fungal infections in the kidney of a living host. The study reveals that the opportunistic human fungal pathogen Candida albicans requires the ability to metabolize proline, an amino acid obtained from the host, to mount virulent infections.
Published Female sex determining gene identified in mice
(via sciencedaily.com) Original source Researchers have identified a gene which is an early determining factor of ovary development in mice.
Published A known environmental hazard can change the epigenetics of cells
(via sciencedaily.com) Original source An international team of researchers has discovered that formaldehyde, a widely spread pollutant and common metabolite in our body, interferes in the epigenetic programming of the cell. This finding expands the knowledge of formaldehyde, previously considered only as a DNA mutagen, and helps establishing a further link with cancer.
Published Research connecting gut bacteria and oxytocin provides a new mechanism for microbiome-promoted health benefits
(via sciencedaily.com) Original source Researchers found that the hormone oxytocin, known to be involved in regulating feeding and social behavior and until now to be produced mostly in the brain, is also produced in the human intestine. Furthermore, gut resident bacteria L. reuteri can affect the production of gut-made oxytocin, providing the first insights into a mechanism by which these bacteria can influence human health.
Published Immunology: Dysfunction of mitochondria drives the exhaustion of T cells
(via sciencedaily.com) Original source In the immune system's fight against cancer and infections, the T cells often lose their power. Now immunologists may have found a possible explanation for this phenomenon.
Published Researchers discover new ultra strong material for microchip sensors
(via sciencedaily.com) Original source Researchers have unveiled a remarkable new material with potential to impact the world of material science: amorphous silicon carbide (a-SiC). Beyond its exceptional strength, this material demonstrates mechanical properties crucial for vibration isolation on a microchip. Amorphous silicon carbide is therefore particularly suitable for making ultra-sensitive microchip sensors.
Published New study sheds light on the molecular mechanisms underlying lipid recycling within cells
(via sciencedaily.com) Original source Our understanding of how cells recycle lipids through autophagy -- a form of cellular degradation -- has grown significantly, thanks to a recent study. Using yeast as a model organism, the researchers explored the molecular mechanisms leading to the degradation of the phospholipid bilayers making up the cell membranes. Their findings improve our understanding of cellular degradation processes and related metabolic disorders.
Published First mice engineered to survive COVID-19 like young, healthy humans
(via sciencedaily.com) Original source Researchers have genetically engineered the first mice that get a human-like form of COVID-19, according to a new study.
Published Plastic-eating bacteria turn waste into useful starting materials for other products
(via sciencedaily.com) Original source Mountains of used plastic bottles get thrown away every day, but microbes could potentially tackle this problem. Now, researchers report that they've developed a plastic-eating E. coli that can efficiently turn polyethylene terephthalate (PET) waste into adipic acid, which is used to make nylon materials, drugs and fragrances.
Published Scientists create special 'telomouse' with human-like telomeres
(via sciencedaily.com) Original source Researchers introduce the 'Telomouse'. By making a subtle genetic alteration in standard lab mice, they've made the mouse telomeres, which protect the chromosome ends, more closely resemble those in humans. The Telomouse model, developed by incorporating a genetic variation from a mouse species with naturally shorter telomeres, provides a valuable resource for in-depth aging and cancer research. This discovery promises to reveal new insights into the genetics of aging and may contribute to enhanced longevity and well-being.
Published Intestinal bacteria metabolite promotes capture of antigens by dendritic cells
(via sciencedaily.com) Original source Dendritic cells are immune cells that capture and present antigens to T cells, activating an immune response. Researchers have discovered that short-chain fatty acids produced by intestinal bacteria regulate a crucial step in this process, the extension of dendritic 'arms.' This breakthrough finding could potentially lead to the development of disease prevention strategies involving beneficial bacteria and new drugs targeting the regulation of dendritic cell function.
Published Controlling organoids with light
(via sciencedaily.com) Original source Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.
Published Protein root discovery seals future of climate-proof plants
(via sciencedaily.com) Original source Researchers have discovered a protein that seals plant roots to regulate the uptake of nutrients and water from the soil, the discovery could help develop climate proof crops that require less water and chemical fertilizers.
Published Researchers solve protein mystery
(via sciencedaily.com) Original source Researchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.
Published Mammalian cells may consume bacteria-killing viruses to promote cellular health
(via sciencedaily.com) Original source Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell. A study suggests that mammalian cells internalize phages as a resource to promote cellular growth and survival.