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Categories: Biology: Molecular, Physics: Optics
Published Research sheds light on the role of PTPRK in tissue repair and cancer
(via sciencedaily.com) Original source New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what is known about the signalling mechanisms involving PTPRK as a phosphatase and its role in colorectal health but also shed new light on the extent of its function via non-catalytic signalling mechanisms.
Published Under pressure: How cells respond to physical stress
(via sciencedaily.com) Original source Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on conditions, small membrane regions can stabilize various lipids to trigger specific cellular responses. These discoveries confirm the existence of well-organized lipid domains and begin to reveal the role they play in cell survival.
Published Dual action antibiotic could make bacterial resistance nearly impossible
(via sciencedaily.com) Original source New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance.
Published New rapid method for determining virus infectivity
(via sciencedaily.com) Original source A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.
Published Fruit fly post-mating behavior controlled by male-derived peptide via command neurons, study finds
(via sciencedaily.com) Original source Scientists have succeeded in pinpointing the neurons within a female fruit fly's brain that respond to signals from the male during mating.
Published A promising new method uses light to clean up forever chemicals
(via sciencedaily.com) Original source A room-temperature method to decompose perfluoroalkyl substances (PFASs) using visible LED light offers a promising solution for sustainable fluorine recycling and PFAS treatment.
Published Exposing dengue's invasion strategies
(via sciencedaily.com) Original source Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease. Now, research uncovered surprising strategies for how dengue and hundreds of other viruses replicate in their hosts, with the potential to aid in developing novel antiviral treatments and vaccines.
Published Not everything that tastes bitter is potentially harmful: But why? Study provides an explanation
(via sciencedaily.com) Original source A bitter taste is traditionally considered a warning sign of potentially toxic substances. But not all bitter substances are harmful. For example, some peptides and free amino acids taste bitter, even though they are non-toxic, nutritious and sometimes even vital for humans. A new study now offers an explanation for this seemingly paradoxical phenomenon.
Published Transient structure in fly leg holds clue to insect shape formation
(via sciencedaily.com) Original source A little leg may reveal something big about how closely related insect species can drastically differ in body shape, according to a new study. The team imaged live cells of fruit flies in the last stages of development over several days and found a new structure that appears to help guide a section of the leg into its final shape.
Published 3D printing of light-activated hydrogel actuators
(via sciencedaily.com) Original source An international team of researchers has embedded gold nanorods in hydrogels that can be processed through 3D printing to create structures that contract when exposed to light -- and expand again when the light is removed. Because this expansion and contraction can be performed repeatedly, the 3D-printed structures can serve as remotely controlled actuators.
Published Secrets behind viral precision
(via sciencedaily.com) Original source New research is shedding light on how viruses ensure their survival by precisely timing the release of new viruses. The discovery offers a new theoretical framework for understanding these dynamic biological phenomena.
Published New technique pinpoints nanoscale 'hot spots' in electronics to improve their longevity
(via sciencedaily.com) Original source Researchers engineered a new technique to identify at the nanoscale level what components are overheating in electronics and causing their performance to fail.
Published Paleolithic diets are not without risks
(via sciencedaily.com) Original source High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma. These results suggest caution when following these diets.
Published Genome recording makes living cells their own historians
(via sciencedaily.com) Original source Genomes can now be used to store information about a variety of transient biological events inside of living cells, as they happen, like a flight recorder collecting data from an aircraft. The method, called ENGRAM, aims to turn cells into their own historians. ENGRAM couples each kind of biological signal or event inside a cell to a symbolic barcode. This new strategy traces and archives the type and timing of biological signals inside the cell by inserting this information into the genome. For example, this record-keeping can track the commands that turn genes on or off.
Published Influenza viruses can use two ways to infect cells
(via sciencedaily.com) Original source Most influenza viruses enter human or animal cells through specific pathways on the cells' surface. Researchers have now discovered that certain human flu viruses and avian flu viruses can also use a second entry pathway, a protein complex of the immune system, to infect cells. This ability helps the viruses infect different species -- and potentially jump between animals and humans.
Published A new addition to the CRISPR toolbox: Teaching the gene scissors to detect RNA
(via sciencedaily.com) Original source CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy.
Published Unique characteristics of previously unexplored protein discovered
(via sciencedaily.com) Original source Research achieves scientific breakthrough in understanding cell division.
Published Immune system in the spotlight
(via sciencedaily.com) Original source Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the immune system. For analysis of the necessary complex antigen processing and transport processes in real time, researchers have developed a 'cage' that is opened with light to release trapped antigens at a specific place and time.
Published Microbeads with adaptable fluorescent colors from visible light to near-infrared
(via sciencedaily.com) Original source Researchers have successfully developed an environmentally friendly, microspherical fluorescent material primarily made from citric acid. These microbeads emit various colors of light depending on the illuminating light and the size of the beads, which suggests a wide range of applications. Furthermore, the use of plant-derived materials allows for low-cost and energy-efficient synthesis.
Published New ways to study spinal cord malformations in embryos
(via sciencedaily.com) Original source Scientists have successfully created mechanical force sensors directly in the developing brains and spinal cords of chicken embryos, which they hope will improve understanding and prevention of birth malformations such as spina bifida.