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Categories: Biology: Molecular, Computer Science: General
Published A hygiene program for chromosomes
(via sciencedaily.com) Original source Researchers identified and characterized a new cellular compartment in vertebrate cells that might be a precursor of today's eucaryotic nucleus. The study reveals that mammalian cells recognize, cluster, sort and keep extrachromosomal DNA -- like transfected plasmid DNA and endogenous circular DNAs originating from telomeres of the chromosome -- away from chromosomal DNA. That suggests that there is a cell autonomous genome defense system.
Published Researchers studied thousands of fertility attempts hoping to improve IVF
(via sciencedaily.com) Original source By genetically testing nearly one thousand embryos, scientists have provided the most detailed analysis of embryo fate following human in vitro fertilization.
Published Edges cause cilia to quickly synchronize their beating pattern
(via sciencedaily.com) Original source Border regions can cause cilia to coordinate their motion creating a unidirectional wave that is essential for biological functions. Scientists proposed a new model describing this synchronized pattern driven by the border region.
Published Small but mighty new gene editor
(via sciencedaily.com) Original source A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders. The tool is an enzyme, AsCas12f, which has been modified to offer the same effectiveness but at one-third the size of the Cas9 enzyme commonly used for gene editing. The compact size means that more of it can be packed into carrier viruses and delivered into living cells, making it more efficient.
Published A lethal parasite's secret weapon: Infecting non-immune cells
(via sciencedaily.com) Original source The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.
Published An advance in cryo-EM could be a significant boon for research on potential cancer therapies
(via sciencedaily.com) Original source A technology called cryo-electron microscopy enables scientists to see the atomic structure of biological molecules in high resolution. But to date, it has been ineffective for imaging small molecules. A team of biochemists devised a solution that makes it possible to hold small protein molecules in place while they're being imaged, which will enable cryo-EM to produce much clearer images of such molecules. The advance is significant because small and medium-sized protein molecules are an area of focus in research on potential new drugs for cancer and other diseases.
Published New information on the most important early stage of embryonic development
(via sciencedaily.com) Original source A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development.
Published Tiny CRISPR tool could help shred viruses
(via sciencedaily.com) Original source Scientists mapped out the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems then used that knowledge to modify its structure and improve its accuracy.
Published Powering the quantum revolution: Quantum engines on the horizon
(via sciencedaily.com) Original source Scientists unveil exciting possibilities for the development of highly efficient quantum devices.
Published Researchers discover disease-causing stem cells in lungs of cystic fibrosis patients
(via sciencedaily.com) Original source Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.
Published A close-up of biological nanomachines: Researchers take a deep look at peroxisomal processes
(via sciencedaily.com) The cell organelles known as 'peroxisomes' dispose toxic substances and fats in the human body, among other things, and, in doing so, they prevent serious illnesses. The 'Pex' group of proteins (peroxisomes biogenesis factors) keep these 'detox units' functioning properly -- and now researchers have shown, at the atomic level, how these highly complex processes proceed.
Published New qubit circuit enables quantum operations with higher accuracy
(via sciencedaily.com) Researchers have developed a novel superconducting qubit architecture that can perform operations between qubits with much higher accuracy than scientists have yet been able to achieve. This architecture, which utilizes a relatively new type of superconducting qubit called fluxonium, is scalable and could be used to someday build a large-scale quantum computer.
Published Did life exist on Mars? Other planets? With AI's help, we may know soon
(via sciencedaily.com) Original source Scientists have discovered a simple and reliable test for signs of past or present life on other planets -- 'the holy grail of astrobiology.' Researchers report that, with 90% accuracy, their artificial intelligence-based method distinguished modern and ancient biological samples from those of abiotic origin.
Published Drug discovery on an unprecedented scale
(via sciencedaily.com) Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers teamed up with industry and supercomputers to carry out one of the world's largest virtual drug screens.
Published Efficient training for artificial intelligence
(via sciencedaily.com) New physics-based self-learning machines could replace the current artificial neural networks and save energy.
Published Same genes behind heart muscle disorders in humans and Dobermanns
(via sciencedaily.com) Original source Researchers have made a significant finding in determining the genetic background of dilated cardiomyopathy in Dobermanns. This research helps us understand the genetic risk factors related to fatal diseases of the heart muscle and the mechanisms underlying the disease, and offers new tools for their prevention.
Published This parasitic plant convinces hosts to grow into its own flesh--it's also an extreme example of genome shrinkage
(via sciencedaily.com) Original source Balanophora shed one third of its genes as it evolved into a streamlined parasitic plant -- an extreme degree of genome shrinkage even among parasites. Along the way this subtropical plant developed the ability to induce the host plant to grow into the parasite's own flesh -- forming chimeric organs that mix host and parasite tissues.
Published Dinosaur feathers reveal traces of ancient proteins
(via sciencedaily.com) Original source Palaeontologists have discovered X-ray evidence of proteins in fossil feathers that sheds new light on feather evolution.
Published Researchers develop first method to study microRNA activity in single cells
(via sciencedaily.com) Researchers have developed the first method to uncover the tasks that microRNAs perform in single cells. This is a huge improvement over existing state-of-the-art methods that require millions of cells and will for the first time allow researchers to study microRNAs in complex tissues such as brains.
Published Split gene-editing tool offers greater precision
(via sciencedaily.com) To make a gene-editing tool more precise and easier to control, engineers split it into two pieces that only come back together when a third molecule is added.