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Categories: Biology: Molecular, Computer Science: General

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In a new study in mice, researchers have uncovered a crucial component for restoring functional activity after spinal cord injury. The neuroscientists have shown that re-growing specific neurons back to their natural target regions led to recovery, while random regrowth was not effective.

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Living things from plants to humans must constantly adjust the chemical soup of proteins -- the workhorse molecules of life -- inside their cells to adapt to stress or changing conditions. Now, researchers have identified a previously unknown molecular mechanism that helps explain how they do it. A team now reveals hairpin-like structures of mRNA that, by zipping and unzipping, help cells change the mix of proteins they produce when under stress.

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Scientists have shown that their steerable lung robot can autonomously maneuver the intricacies of the lung, while avoiding important lung structures.

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How do our muscles respond at the molecular level to exercise? Researchers have unraveled the cellular basis and signaling pathways responsible for the positive impact of physical activity on our overall health. Regulatory T cells, a type of immune cell, play a critical role in ensuring proper muscle function. These novel insights are paving the path towards precision medicines targeting metabolic disorders like obesity and diabetes, as well as muscle-related illnesses.

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Building on work in human-computer interaction that aims to incorporate sustainability and reuse into the field, researchers introduce 'garbatrage,' a framework for prototype builders centered around repurposing underused devices.

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A research team has harnessed the power of deep reinforcement learning to replicate the flow of water when disturbed. The replication allowed for recreating water flow in real time based on only a small amount of data, opening up the possibility for virtual reality interactions involving water.

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A research team has uncovered a treasure trove of uncharacterized proteins. Embracing the recent deep learning revolution, they discovered hundreds of new protein families and even a novel predicted protein fold.

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A new generation of cloud services is on the rise. It is based on the paradigm of 'serverless computing'. A recent article deals with the history, status and potential of serverless computing.

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Scientists have synthesized spider silk from genetically modified silkworms, producing fibers six times tougher than the Kevlar used in bulletproof vests. The study is the first to successfully produce full-length spider silk proteins using silkworms. The findings demonstrate a technique that could be used to manufacture an environmentally friendly alternative to synthetic commercial fibers such as nylon.

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A team has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. They disclosed previously unknown details, such as precise conformational changes, that help to explain the enzyme's biochemistry. This work might help researchers engineer enzymes that facilitate unusual chemistry or are highly efficient at room temperature that are useful in chemical industry.

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Researchers combined soft microactuators with high-energy-density chemical fuel to create an insect-scale quadrupedal robot that is powered by combustion and can outrace, outlift, outflex and outleap its electric-driven competitors.

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Researchers have grown a high-performing 2D semiconductor to a full-size, industrial-scale wafer. In addition, the semiconductor material, indium selenide (InSe), can be deposited at temperatures low enough to integrate with a silicon chip.

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Researchers have developed a way of detecting the early onset of deadly infectious diseases using a test so ultrasensitive that it could someday revolutionize medical approaches to epidemics. The test is an electronic sensor contained within a computer chip. It employs nanoballs -- microscopic spherical clumps made of tinier particles of genetic material -- and combines that technology with advanced electronics.

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A new study sheds new light on the origins of modern brain cells. Researchers find evidence that specialized secretory cells found in placozoans, tiny sea creatures the size of a grain of sand, have many similarities to the neuron, such as the genes required to create a partial synapse. From an evolutionary point of view, early neurons might have started as something like these cells, eventually gaining the ability to create a complete synapse, form axons and dendrites and create ion channels that generate fast electrical signals -- innovations which gave rise to the neuron in more complex animals such as jellyfish. Though the complete story of how the first neuron appeared remains to be told, the study demonstrates that the basic building blocks for our brain cells were forming in the ancestors of placozoans grazing inconspicuously in the shallow seas of Earth around 800 million years ago.

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Scientists are investigating the previously largely unknown biosynthetic pathway that leads to the formation of cardenolides in plants. In a new study, they present two enzymes from the CYP87A family as key enzymes that catalyze the formation of pregnenolone, the precursor for the biosynthesis of plant steroids, in two different plant families. The discovery of such enzymes should help to develop platforms for the cheap and sustainable production of high quality steroid compounds for medical use.

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Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

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With Style2Fab, makers can rapidly customize models of 3D-printable objects, such as assistive devices, without hampering their functionality.

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Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.

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Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.

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Scientists have confirmed that human brains are naturally wired to perform advanced calculations, much like a high-powered computer, to make sense of the world through a process known as Bayesian inference.