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Categories: Biology: Molecular, Computer Science: General
Published From hagfish to membrane: Modeling age-related macular degeneration
(via sciencedaily.com) Original source Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.
Published Battery-free robots use origami to change shape in mid-air
(via sciencedaily.com) Researchers have developed small robotic devices that can change how they move through the air by 'snapping' into a folded position during their descent. Each device has an onboard battery-free actuator, a solar power-harvesting circuit and controller to trigger these shape changes in mid-air.
Published Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
(via sciencedaily.com) Original source During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.
Published AI foundation model for eye care to supercharge global efforts to prevent blindness
(via sciencedaily.com) Researchers have developed an artificial intelligence (AI) system that has the potential to not only identify sight-threatening eye diseases but also predict general health, including heart attacks, stroke, and Parkinson's disease.
Published Mysterious family of microbial proteins hijack crops' cellular plumbing
(via sciencedaily.com) Original source Some crop pathogens use a clever trick to multiply and spread infection: they hijack the plant's cellular plumbing. In a new study, researchers unveil a class of bacterial proteins that fold into a straw-like shape and insert themselves into the plant cell membrane, allowing the inside of the leaf to become waterlogged. The researchers also figured out a possible way to block the water channel proteins and prevent infection.
Published A protein on cancer cells supports the immune response against tumors
(via sciencedaily.com) Original source Scientists identify a new and surprising function of a membrane protein on the surface of cancer cells: It supports and stabilizes an important 'co-stimulatory' factor that enhances the activation of T cells, thus improving the immune response against the tumor.
Published 'Dormant' HIV produces RNA and proteins during anti-retroviral therapy
(via sciencedaily.com) Original source HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long been thought to be dormant, but two independent groups of researchers report that a subset of these cells spontaneously produce HIV RNA and proteins that may impact patients' HIV-specific immune responses.
Published Comprehensive insulin signalling map shows interplay between genes and diet
(via sciencedaily.com) Original source Researchers have produced a comprehensive picture of insulin signalling in mice and suggest that it is shaped by entangled effects of genetics and diet.
Published Not too big: Machine learning tames huge data sets
(via sciencedaily.com) A machine-learning algorithm demonstrated the capability to process data that exceeds a computer's available memory by identifying a massive data set's key features and dividing them into manageable batches that don't choke computer hardware. The algorithm set a world record for factorizing huge data sets during a test run on the world's fifth-fastest supercomputer. Equally efficient on laptops and supercomputers, the highly scalable algorithm solves hardware bottlenecks that prevent processing information from data-rich applications in cancer research, satellite imagery, social media networks, national security science and earthquake research, to name just a few.
Published Super antifreeze in cells: The ability to survive in ice and snow developed in animals far earlier than we thought
(via sciencedaily.com) Original source More than 400 million years ago, an insect-like animal called the springtail developed a small protein that prevents its cells from freezing.
Published Researcher helps boost immune system memory against influenza
(via sciencedaily.com) Original source Researchers are one step closer to making the T cell army stronger. In a recent study, researchers found that by manipulating one molecular signaling pathway in the T cells that participate in clearing influenza virus in the lungs, the strength and longevity of immunological memory produced can be improved.
Published Auxin signaling pathway controls root hair formation for nitrogen uptake
(via sciencedaily.com) Original source Root hairs represent a low-cost strategy to enhance nutrient uptake because they can significantly increase the nutrient-acquiring surface of plant roots. While primary and lateral roots are stimulated to elongate when plants grow under mild nitrogen deficiency, the existence of such a foraging response for root hairs and its underlying regulatory mechanism remain elusive. Now, researchers have revealed a framework composed of specific molecular players meditating auxin synthesis, transport and signaling that triggers root hair elongation for nitrogen acquisition.
Published Magnetic whirls pave the way for energy-efficient computing
(via sciencedaily.com) Researchers have been able to increase the diffusion of magnetic whirls, so called skyrmions, by a factor of ten.
Published AI can help write a message to a friend -- but don't do it
(via sciencedaily.com) Using artificial intelligence applications to help craft a message to a friend is not a good idea -- at least if your friend finds out about the use of AI, a new study suggests.
Published Nutrients drive cellular reprogramming in the intestine
(via sciencedaily.com) Original source Researchers have unveiled an intriguing phenomenon of cellular reprogramming in mature adult organs, shedding light on a novel mechanism of adaptive growth. The study, which was conducted on fruit flies (Drosophila), provides further insights into dedifferentiation -- where specialized cells that have specific functions transform into less specialized, undifferentiated cells like stem cells.
Published These worms have rhythm
(via sciencedaily.com) Original source Researchers have developed a new imaging technique to observe active gene expression in real time. They found that four molecules work together to control the timing of each stage of the C. elegans worm's development. This timekeeping process could provide important clues about the natural rhythm of development in humans and other animals.
Published 'Brainless' robot can navigate complex obstacles
(via sciencedaily.com) Researchers who created a soft robot that could navigate simple mazes without human or computer direction have now built on that work, creating a 'brainless' soft robot that can navigate more complex and dynamic environments.
Published What do neurons, fireflies and dancing the Nutbush have in common?
(via sciencedaily.com) Synchronicity is all around us, but it is poorly understood. Computer scientists have now developed new tools to understand how human and natural networks fall in and out of sync.
Published Online AI-based test for Parkinson's disease severity shows promising results
(via sciencedaily.com) A new artificial intelligence tool can help people with Parkinson's disease remotely assess the severity of their symptoms within minutes. While expert neurologists performed slightly better than the AI model, the AI model outperformed the primary care physicians with UPDRS certification.
Published Researchers grow embryonic humanized kidneys inside pigs for 28 days
(via sciencedaily.com) Original source Researchers have successfully created chimeric embryos containing a combination of human and pig cells. When transferred into surrogate pig mothers, the developing humanized kidneys had normal structure and tubule formation after 28 days. This is the first time that scientists have been able to grow a solid humanized organ inside another species, though previous studies have used similar methods to generate human tissues such as blood or skeletal muscle in pigs.