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Categories: Biology: Molecular, Computer Science: Artificial Intelligence (AI)
Published Intermittent fasting shows promise in improving gut health, weight management
(via sciencedaily.com) Original source Participants following an intermittent fasting and protein-pacing regimen, which involves evenly spaced protein intake throughout the day, saw better gut health, weight loss and metabolic responses. These benefits were notably greater than those seen with simple calorie restriction. The findings could advance our understanding of the relationship between the gut microbiome and metabolism and improve strategies for managing obesity.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published 'Cloaked' proteins deliver cancer-killing therapeutics into cells
(via sciencedaily.com) Original source Scientists have designed a way to 'cloak' proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.
Published Tracking animals without markers in the wild
(via sciencedaily.com) Original source Researchers developed a computer vision framework for posture estimation and identity tracking which they can use in indoor environments as well as in the wild. They have thus taken an important step towards markerless tracking of animals in the wild using computer vision and machine learning.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published AI headphones let wearer listen to a single person in a crowd, by looking at them just once
(via sciencedaily.com) Original source Engineers have developed an artificial intelligence system that lets someone wearing headphones look at a person speaking for three to five seconds to 'enroll' them. The system then plays just the enrolled speaker's voice in real time, even as the pair move around in noisy environments.
Published Observing mammalian cells with superfast soft X-rays
(via sciencedaily.com) Original source Researchers have developed a new technique to view living mammalian cells. The team used a powerful laser, called a soft X-ray free electron laser, to emit ultrafast pulses of illumination at the speed of femtoseconds, or quadrillionths of a second. With this they could capture images of carbon-based structures in living cells for the first time, before the soft X-ray radiation damaged them.
Published AI poised to usher in new level of concierge services to the public
(via sciencedaily.com) Original source Concierge services built on artificial intelligence have the potential to improve how hotels and other service businesses interact with customers, a new paper suggests.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development
(via sciencedaily.com) Original source Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Novel approach to interrogate tissue-specific protein-protein interactions
(via sciencedaily.com) Original source Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published Tracking down the genetic causes of lupus to personalize treatment
(via sciencedaily.com) Original source Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.
Published Exploring diversity in cell division
(via sciencedaily.com) Original source Animals and fungi predominantly use two different modes of cell division -- called open and closed mitosis, respectively. A new study has shown that different species of Ichthyosporea -- marine protists that are close relatives of both animals and fungi -- use either open and closed mitosis, closely correlated to whether the species has multinucleate life cycle stages. The study demonstrates the way animals do cell division might have evolved long before animals themselves did and how this is linked to an organism's life cycle.
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
(via sciencedaily.com) Original source Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published 3D printing robot creates extreme shock-absorbing shape, with help of AI
(via sciencedaily.com) Original source See how an autonomous robot created a shock-absorbing shape no human ever could -- and what it means for designing safer helmets, packaging, car bumpers, and more.
Published Studies reveal cell-by-cell changes caused when pig hearts and kidneys are transplanted into humans
(via sciencedaily.com) Original source Two new studies detail the changes seen at the single-cell level in pig organs and recipient human bodies before, during, and just after the xenotransplantation surgeries in the decedents.
Published Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
(via sciencedaily.com) Original source Although periodontitis is an extremely prevalent disorder, it is challenging to conduct detailed and comprehensive analyses of its progression at the cellular level. Recently, researchers developed an improved periodontitis mouse model that simplifies the collection and analysis of multiple periodontal tissue types. Using this model, they clarified the role of an important signaling pathway in the inflammatory response of periodontal tissue, paving the way for better diagnostic and therapeutic strategies for periodontitis.
Published Robot-phobia could exacerbate hotel, restaurant labor shortage
(via sciencedaily.com) Original source Using more robots to close labor gaps in the hospitality industry may backfire and cause more human workers to quit, according to a new study. The study, involving more than 620 lodging and food service employees, found that 'robot-phobia' -- specifically the fear that robots and technology will take human jobs -- increased workers' job insecurity and stress, leading to greater intentions to leave their jobs. The impact was more pronounced with employees who had real experience working with robotic technology. It also affected managers in addition to frontline workers.
Published Modern plant enzyme partners with surprisingly ancient protein
(via sciencedaily.com) Original source Scientists have discovered that a protein responsible for the synthesis of a key plant material evolved much earlier than suspected. This new research explored the origin and evolution of the biochemical machinery that builds lignin, a structural component of plant cell walls with significant impacts on the clean energy industry.
Published Sweet taste receptor affects how glucose is handled metabolically by humans
(via sciencedaily.com) Original source The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption and assimilation, as part of this system. A team found that stimulation and inhibition of the sweet receptor helps regulate glucose metabolism in humans and may have implications for managing such metabolic disorders as diabetes.
Published Scientists discover mechanism of sugar signaling in plants
(via sciencedaily.com) Original source A paper describes how the moving parts of a particular plant protein control whether plants can grow and make energy-intensive products such as oil -- or instead put in place a series of steps to conserve precious resources. The study focuses specifically on how the molecular machinery is regulated by a molecule that rises and falls with the level of sugar -- plants' main energy source.