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Categories: Biology: Molecular, Computer Science: Artificial Intelligence (AI)
Published The fast and the fibrous: Developing the muscles you need for speed
(via sciencedaily.com) Original source Researchers have identified the role of the large Maf transcription factor family in regulating fast twitch muscle fibers. A mouse model lacking Maf expression in the skeletal muscles exhibited a significant loss of type IIb myofibers, a subtype of fast twitch fibers. Overexpression of large Mafs promoted type IIb muscle fiber induction. The large Maf family may represent potential targets for developing treatments for muscular disorders involving fast twitch fibers.
Published How tasty is the food?
(via sciencedaily.com) Original source A hormone and specialized brain cells regulate feeding behavior in mice.
Published Where do our limbs come from?
(via sciencedaily.com) Original source Scientists have uncovered new clues about the origin of paired appendages -- a major evolutionary step that remains unresolved and highly debated.
Published A look into the heart of cellular waste disposal
(via sciencedaily.com) Original source Researchers reveal how a nanomachine takes care of cleaning up inside the cell.
Published Engineers create bacteria that can synthesize an unnatural amino acid
(via sciencedaily.com) Original source Researchers have engineered bacteria to synthesize an amino acid that contains a rare functional group that others have shown to have implications in the regulation of our immune system. The researchers also taught a single bacterial strain to create the amino acid and place it at specific sites within target proteins. These findings provide a foundation for developing unique vaccines and immunotherapies in the future.
Published Researchers find new mechanism for sodium salt detoxification in plants
(via sciencedaily.com) Original source A team of researchers has found a mechanism in thale cress (Arabidopsis thaliana) which enables plants to provide protection against salt stress for their sensitive stem cells in the meristem at the root tip.
Published Researchers build bee robot that can twist
(via sciencedaily.com) Original source A robotic bee that can fly fully in all directions has been developed. With four wings made out of carbon fiber and mylar as well as four light-weight actuators to control each wing, the Bee++ prototype is the first to fly stably in all directions. That includes the tricky twisting motion known as yaw, with the Bee++ fully achieving the six degrees of free movement that a typical flying insect displays.
Published A multiomics approach provides insights into flu severity
(via sciencedaily.com) Original source Researchers were able to identify changes in the accessibility (that is, the 'readability') of transposable elements. To do this, the researchers used an approach combining various sets of multiomics data, which characterize and quantify collections of biomolecules in cells or organisms. One was the transcriptome, which consists of all copies of RNA transcribed from DNA in the cell. The other was the epigenome, which is the collection of chemical changes to DNA that modify gene expression. An advantage of this multiomics approach is that they were able to identify families of transposable elements with changes in accessibility, which would have likely been missed by previous approaches.
Published Designing synthetic receptors for precise cell control
(via sciencedaily.com) Original source Scientists have developed a groundbreaking new technique for engineering biosensors that respond sensitively to specific biomolecules, enhancing cell migration and targeting in cancer treatment. The findings could lead to more precise control over cellular processes for a wide range of therapeutic applications.
Published Under control to the very end -- how our cells kill themselves
(via sciencedaily.com) Original source Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. Researchers have now been able to elucidate the exact mechanism at the atomic level.
Published A guide through the genome
(via sciencedaily.com) Original source Plants show enormous variety in traits relevant to breeding, such as plant height, yield and resistance to pests. One of the greatest challenges in modern plant research is to identify the differences in genetic information that are responsible for this variation.
Published How plants use sugar to produce roots
(via sciencedaily.com) Original source Along with sugar reallocation, a basic molecular mechanism within plants controls the formation of new lateral roots. Botanists have demonstrated that it is based on the activity of a certain factor, the target of rapamycin (TOR) protein. A better understanding of the processes that regulate root branching at the molecular level could contribute to improving plant growth and therefore crop yields, according to the research team leader.
Published Synthetic biology: proteins set vesicles in motion
(via sciencedaily.com) Original source Biophysicists have designed a new cell-like transport system that represents an important milestone on the road to artificial cells.
Published Cancer cells use a new fuel in absence of sugar
(via sciencedaily.com) Original source Researchers have discovered a new nutrient source that pancreatic cancer cells use to grow. The molecule, uridine, offers insight into both biochemical processes and possible therapeutic pathways. The findings show that cancer cells can adapt when they don't have access to glucose.
Published Watch these cells rapidly create protrusions for exploration and movement
(via sciencedaily.com) Original source In order to move, cells must be able to rapidly change shape. A team of researchers show that cells achieve this by storing extra 'skin' in folds and bumps on their surface. This cell surface excess can be rapidly deployed to cover temporary protrusions and then folded away for next time.
Published Scales or feathers? It all comes down to a few genes
(via sciencedaily.com) Original source Scales, spines, feathers and hair are examples of vertebrate skin appendages, which constitute a remarkably diverse group of micro-organs. Despite their natural multitude of forms, these appendages share early developmental processes at the embryonic stage. Researchers have discovered how to permanently transform the scales that normally cover the feet of chickens into feathers, by specifically modifying the expression of certain genes.
Published A channel involved in pain sensation can also suppress it
(via sciencedaily.com) Original source Pain is good. It's the body's way to keep an animal from harming itself or repeating a dangerous mistake. But sometimes the debilitating sensation can get in the way. So evolution has devised ways to tamp that response down under certain circumstances.
Published Researchers reveal DNA repair mechanism
(via sciencedaily.com) Original source A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.
Published How superbug A. baumannii survives metal stress and resists antibiotics
(via sciencedaily.com) Original source The deadly hospital pathogen Acinetobacter baumannii can live for a year on a hospital wall without food and water. Then, when it infects a vulnerable patient, it resists antibiotics as well as the body's built-in infection-fighting response. The World Health Organization (WHO) recognizes it as one of the three top pathogens in critical need of new antibiotic therapies. Now, an international team, led by Macquarie University researchers Dr. Ram Maharjan and Associate Professor Amy Cain, have discovered how the superbug can survive harsh environments and then rebound, causing deadly infections. They have found a single protein that acts as a master regulator. When the protein is damaged, the bug loses its superpowers allowing it to be controlled, in a lab setting. The research is published this month in Nucleic Acids Research.
Published Can't find your phone? There's a robot for that
(via sciencedaily.com) Original source Engineers have discovered a new way to program robots to help people with dementia locate medicine, glasses, phones and other objects they need but have lost.