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Categories: Biology: Molecular, Space: Astronomy

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New research has advanced our knowledge of multiple roles for PTPRK, a receptor tyrosine phosphatase linked to the regulation of cell-cell adhesion, growth factor signalling and tumor suppression. Through a characterization of the function of PTPRK in human cell lines and mice, the team distinguished catalytic and non-catalytic functions of PTPRK. The findings extend what is known about the signalling mechanisms involving PTPRK as a phosphatase and its role in colorectal health but also shed new light on the extent of its function via non-catalytic signalling mechanisms.

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Using the James Webb Space Telescope (JWST), astronomers imaged a new exoplanet that orbits a star in the nearby triple system Epsilon Indi. The planet is a cold super-Jupiter exhibiting a temperature of around 0 degrees Celsius and a wide orbit comparable to that of Neptune around the Sun. This measurement was only possible thanks to JWST's unprecedented imaging capabilities in the thermal infrared. It exemplifies the potential of finding many more such planets similar to Jupiter in mass, temperature, and orbit. Studying them will improve our knowledge of how gas giants form and evolve in time.

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Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists have used cryo-electron microscopy to observe how lipids and proteins at the plasma membrane interact and react to mechanical stress. This work shows that, depending on conditions, small membrane regions can stabilize various lipids to trigger specific cellular responses. These discoveries confirm the existence of well-organized lipid domains and begin to reveal the role they play in cell survival.

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New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance.

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A new method that can rapidly determine whether a virus is infectious or non-infectious could revolutionize the response to future pandemics, researchers report.

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A new study shows that over half of the medicines stocked in space -- staples such as pain relievers, antibiotics, allergy medicines, and sleep aids -- would expire before astronauts could return to Earth.

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Scientists have succeeded in pinpointing the neurons within a female fruit fly's brain that respond to signals from the male during mating.

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A study extends the definition of a habitable zone for planets to include their star's magnetic field.

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Researchers have found a link between some of the largest and smallest objects in the cosmos: supermassive black holes and dark matter particles. Their new calculations reveal that pairs of supermassive black holes (SMBHs) can merge into a single larger black hole because of previously overlooked behavior of dark matter particles, proposing a solution to the longstanding 'final parsec problem' in astronomy.

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Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease. Now, research uncovered surprising strategies for how dengue and hundreds of other viruses replicate in their hosts, with the potential to aid in developing novel antiviral treatments and vaccines.

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A bitter taste is traditionally considered a warning sign of potentially toxic substances. But not all bitter substances are harmful. For example, some peptides and free amino acids taste bitter, even though they are non-toxic, nutritious and sometimes even vital for humans. A new study now offers an explanation for this seemingly paradoxical phenomenon.

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A little leg may reveal something big about how closely related insect species can drastically differ in body shape, according to a new study. The team imaged live cells of fruit flies in the last stages of development over several days and found a new structure that appears to help guide a section of the leg into its final shape.

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Europa and Enceladus, icy moons of Jupiter and Saturn respectively, have evidence of oceans beneath their crusts. A NASA experiment suggests -- if these oceans support life -- signatures of that life in the form of organic molecules (like amino acids and nucleic acids) could survive just under the surface ice despite the harsh, ionizing radiation on these worlds. If robotic landers were to go to these moons to look for life signs, they would not have to dig very deep to find amino acids that have survived being altered or destroyed by radiation.

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The first rumblings of the Sun's next 11-year solar cycle have been detected in sound waves inside our home star -- even though it is only halfway through its current one. This existing cycle is now at its peak, or 'solar maximum' -- which is when the Sun's magnetic field flips and its poles swap places -- until mid-2025.

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Space storms could soon be forecasted with greater accuracy than ever before thanks to a big leap forward in our understanding of exactly when a violent solar eruption may hit Earth. Scientists say it is now possible to predict the precise speed a coronal mass ejection (CME) is travelling at and when it will smash into our planet -- even before it has fully erupted from the Sun.

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Europe's next big space mission -- a telescope that will hunt for Earth-like rocky planets outside of our solar system -- is on course to launch at the end of 2026. PLATO, or PLAnetary Transits and Oscillations of stars, is being built to find nearby potentially habitable worlds around Sun-like stars that we can examine in detail.

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So far, only about ten intermediate-mass black holes have been discovered in the entire universe. The newly identified black hole causes surrounding stars in a cluster to move in an unexpectedly orderly way.

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New research is shedding light on how viruses ensure their survival by precisely timing the release of new viruses. The discovery offers a new theoretical framework for understanding these dynamic biological phenomena.

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High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma. These results suggest caution when following these diets.

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The newly discovered planet TIC 241249530 b has the most highly elliptical, or eccentric, orbit of any known planet. It appears to be a juvenile planet that is in the midst of becoming a hot Jupiter, and its orbit is providing some answers to how such large, scorching planets evolve.